Protein Alignment MED16 and Med16

DIOPT Version :10

• Sequence 1: NP_611650.2
• Gene: MED16 / 37535
• FlyBaseID: FBgn0034707
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_036011628.1
• Gene: Med16 / 216154
• MGIID: 2158394
• Length: 829
• Species: Mus musculus
• Alignment Length: 896
• Identity: 258/896 - (28%)
• Similarity: 414/896 - (46%)
• Gaps: 152/896 - (16%)

  Fly     1 MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSA-LQSAIFPASHGGDAGDGSLPGAGLAVG 64
            |.:.|..|.::::|.:..|...:.|:.|.||::||:. |::.....:|
Mouse     2 MDLAYVCEWEKWAKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTH----------------- 49

  Fly    65 ASNSHVYVCDIVTPWEYYKVCSSKS-LISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQ 128
                .:::.|...|||.:.|.|..| .|:.|:|..:|.:||.....|:::.|...:...|.|...
Mouse    50 ----MIHILDTEHPWEVHSVSSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESS 110

  Fly   129 YYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSS 193
            ..:.|..:.|:...:..||..:..:..|...:.:.|||.||:.. |:|:.|||...||.:.:|.|
Mouse   111 VGSQVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFS-PSLTLFGGKPMEGWIAVTVS 174

  Fly   194 GLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQ 258
            ||:....|.            |:.:|:..|.:|..:   |..:....:..:..|.:.:|.:.|..
Mouse   175 GLVTVSLLK------------PSGQVLTSTESLCRL---RGRVALADIAFTGGGNIVVAAADGSS 224

  Fly   259 QQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLG-PLDGRR------ISHLKW-TRIANEDVI 315
            ...|:.:||.:|:     :.:...|.:|...|:|:. ..|..|      |:|||: .|..:|.|:
Mouse   225 ASPVKFYKVCVSV-----VSEKCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVL 284

  Fly   316 FIAYACPDGAGSQLEQWTLTRRHQSVHALLQGGGGANNKPNEFVQSESWEQVGKVQLNASLAD-- 378
            ..|   .....|.:|.|:|.:....|:.:.|     ...|   |..:....:.|.::.::..|
Mouse   285 LCA---SSQTSSLVECWSLRKEGLPVNNIFQ-----QISP---VVGDKQPMILKWRILSATNDLD 338

  Fly   379 -----------ISVTRLSVSTPDSCQVYAIL------QDNSVQVLEPNSM-----------KQLN 415
                       ||:|...:......|.|..|      ||.||.::...|:           :.|:
Mouse   339 RVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSAPRSLD 403

  Fly   416 HTQFDRLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQA------PL-PKQGGSGLL-LLEY 472
            .....|......||.|.:..|:.:|..|:..|:|.:|..::.      || ||.....|| ||||
Mouse   404 EPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHPLEPKLALQHLLFLLEY 468

  Fly   473 CIVTGCDASDVLL-LNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRM------QQQ 530
            |:|||.|..|:|| :..|.:::|||:|.:.:|||...::.......||:|:::|::      :..
Mouse   469 CMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTVARVC 533

  Fly   531 EFDNLIILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDV--DTVMLNLDAKDFTVEPV 593
            ::...:.|.||::|.||||||..|...||.|.|.|| ::...|.||  |.||:||..::|.::..
Mouse   534 DYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLA-EICAKITDVDIDKVMINLKTEEFVLDMN 597

  Fly   594 MLQSLQQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLN 658
            .||:||||:|||.|..|.:|..||.:.     |..||.:...||..::..||||:|:|||||||.
Mouse   598 TLQALQQLLQWVGDFVLYLLVSLPNQG-----SPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLK 657

  Fly   659 TQCLPVYTKTMDNIDVLVILFRLLTRL------AQNPAEPDEMLLDECSLLSKQLLIPQPTKFNP 717
            ..||||||.|.|..|.:.:||||||:|      ....:||||.|:|||.||..|||:|     |.
Mouse   658 PSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGAASEPDEGLVDECCLLPSQLLVP-----NL 717

  Fly   718 TTLLSAQGFAA-VKSGQ-LQFTSMEEPTCLQDMETEEVVFASSVKDGVS------------NLQL 768
            ..|.::.|..: ::..| |:......||......|.::       ||::            .|.|
Mouse   718 DWLPASDGLVSRLQPKQPLRLRFGRAPTLPSSTSTLQL-------DGLTRAPGQPKIDHLRRLHL 775

  Fly   769 GARPS-HIRRCARCGFVFVNNASKVAKTSALKAWFSKWL-HCHCGGFWKQV 817
            ||.|: ..:.|.|||.|.:..:..  ||:|:..|..:|: :|.|||.|::|
Mouse   776 GAYPTEECKACTRCGCVTMLKSPN--KTTAVTQWEQRWIKNCLCGGLWRRV 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED16	NP_611650.2	Med16	128..816	CDD:371639	227/764 (30%)
Med16	XP_036011628.1	WD40 repeat	26..68	CDD:293791	13/62 (21%)
		WD40	59..98	CDD:197651	13/38 (34%)
		WD40 repeat	73..113	CDD:293791	10/39 (26%)
		Med16	108..822	CDD:371639	226/765 (30%)
		WD40 repeat	151..193	CDD:293791	15/54 (28%)