DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MED16 and MED16

DIOPT Version :10

Sequence 1:NP_611650.2 Gene:MED16 / 37535 FlyBaseID:FBgn0034707 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_005472.2 Gene:MED16 / 10025 HGNCID:17556 Length:877 Species:Homo sapiens


Alignment Length:883 Identity:253/883 - (28%)
Similarity:400/883 - (45%) Gaps:148/883 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSA-LQSAIFPASHGGDAGDGSLPGAGLAVG 64
            |.:.|..|.:::||.:..|...:.|:.|.||::||:. |:|           .|..|        
Human    13 MDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRS-----------DDQDL-------- 58

  Fly    65 ASNSHVYVCDIVTPWEYYKVCSS-KSLISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQ 128
              ...:::.|...||:.:.:.|. ...|:.|:|..:|.:||.....|:::.|...:...|.|...
Human    59 --TRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESS 121

  Fly   129 YYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSS 193
            ..:.|..:.|:...:..||..:..:..|...:.:.|||.||:.. |:|:.|||...||.:.:|.|
Human   122 VGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFS-PSLTLFGGKPMEGWIAVTVS 185

  Fly   194 GLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQ 258
            ||:....|.            |:.:|:..|.:|..:   |..:....:..:..|.:.:|.:.|..
Human   186 GLVTVSLLK------------PSGQVLTSTESLCRL---RGRVALADIAFTGGGNIVVATADGSS 235

  Fly   259 QQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLG-PLDGRR------ISHLKW-TRIANEDVI 315
            ...||.:||.:|:     :.:...|.:|...|:|:. ..|..|      |:|||: .|..:|.|:
Human   236 ASPVQFYKVCVSV-----VSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVL 295

  Fly   316 FIAYACPDGAGSQLEQWTLTRRHQSVHALLQG-GGGANNKPNEFVQ------SESWEQVGKVQLN 373
            ..|   .....|.:|.|:|.:....|:.:.|. .....:|....::      :...::|..|.| 
Human   296 LCA---SSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVAL- 356

  Fly   374 ASLADISVTRLSVSTPDSCQVYAIL------QDNSVQVLEPNSM------------KQLNHTQFD 420
             ....||:|...:......|.|..|      .|.||.::...|:            :.::.....
Human   357 -PKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK 420

  Fly   421 RLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQ-APL---PKQGGSG----LLLLEYCIVTG 477
            |...|..||...:..|:.:|..|:..|||.:|..:: :|.   |.:.|..    |.|||||:|||
Human   421 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTG 485

  Fly   478 CDASDVLL-LNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRM------QQQEFDNL 535
            .|..|:|| :....:::|||||.:.:|||.:.::.......||:|:::|::      :..::...
Human   486 YDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTK 550

  Fly   536 IILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDV--DTVMLNLDAKDFTVEPVMLQSL 598
            :.|.|||:|.||||||..|...||.|.|.|. ::...|.||  |.||:||..::|.::...||:|
Human   551 LFLIAISSTLKSLLRPHFLNTPDKSPGDRLT-EICTKITDVDIDKVMINLKTEEFVLDMNTLQAL 614

  Fly   599 QQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLNTQCLP 663
            |||:|||.|..|.:|..||.:.     |..||.:...||..::..||||:|:|||||||...|||
Human   615 QQLLQWVGDFVLYLLASLPNQG-----SLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLP 674

  Fly   664 VYTKTMDNIDVLVILFRLLTRL-----AQNPA-EPDEMLLDECSLLSKQLLIPQ----------P 712
            |||.|.|..|.:.:||||||:|     .:.|| ||||.|:|||.||..|||||.          .
Human   675 VYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLV 739

  Fly   713 TKFNPTTLLSAQ-GFAAVKSGQ---LQFTSME----EPTCLQDMETEEVVFASSVKDGVSNLQLG 769
            ::..|...|..| |.|....|.   ||...:.    :|..                |.:..|.||
Human   740 SRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKI----------------DHLRRLHLG 788

  Fly   770 ARPS-HIRRCARCGFVFVNNASKVAKTSALKAWFSKWL 806
            |.|: ..:.|.|||.|.:..:..  :|:|:|.|..:|:
Human   789 ACPTEECKACTRCGCVTMLKSPN--RTTAVKQWEQRWI 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MED16NP_611650.2 Med16 128..816 CDD:371639 223/754 (30%)
MED16NP_005472.2 WD 1 21..71 13/50 (26%)
WD40 70..109 CDD:197651 6/39 (15%)
WD 2 72..119 10/47 (21%)
WD40 repeat 85..116 CDD:293791 8/31 (26%)
Med16 119..828 CDD:371639 227/775 (29%)
WD 3 120..165 8/44 (18%)
WD40 repeat 153..204 CDD:293791 15/50 (30%)
WD 4 166..203 13/36 (36%)
WD 5 204..257 9/52 (17%)
WD 6 258..334 22/83 (27%)
WD 7 335..415 17/92 (18%)
WD 8 416..460 8/55 (15%)
WD 9 461..495 15/41 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 848..877
Blue background indicates that the domain is not in the aligned region.

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