Protein Alignment Fbxo42 and Y50D7A.1

DIOPT Version :10

• Sequence 1: NP_611647.1
• Gene: Fbxo42 / 37532
• FlyBaseID: FBgn0034704
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001379295.1
• Gene: Y50D7A.1 / 175193
• WormBaseID: WBGene00021751
• Length: 647
• Species: Caenorhabditis elegans
• Alignment Length: 717
• Identity: 153/717 - (21%)
• Similarity: 261/717 - (36%)
• Gaps: 231/717 - (32%)

  Fly    27 LPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIVKNLVRRSRH-----------------NLEKGL 74
            ||:..|..:..|| .|.||:....:|.....:....|:...|                 :.|:.:
 Worm    38 LPEPALNKVLRYL-RYPDLQTLKSICPELTDLCDLHVKLMDHSEFYTHPKFQFERCSPDDEEEEV 101

  Fly    75 IDFRLRWEVFSQQTVNGGAGALLSFIAGRFAHSAV-----RQD---------NSMYVFGGGS--- 122
            :..|:|    |.:|  ..:...|..:|..|....|     ||:         .|:|:|||.:
 Worm   102 VAGRIR----SPRT--SSSSGQLDKVADEFVVKDVEIMSERQNACATYFEPTRSLYLFGGEAIDG 160

  Fly   123 ---SSDTTFNDLWRFDLTHMRWARP-VATGTYPSPKGSASMVAWRNQLILFGG----WRYPSLHP 179
               :....||||||.|...::|:|. :::..|||....||:|.|..|||||||    .|.|..:.
 Worm   161 DEHTPGAVFNDLWRLDTATLKWSRVIISSAPYPSAMCYASLVTWGTQLILFGGNDNRRRCPFANV 225

  Fly   180 PYQPWCLFDELHYYDLGKNRWLLRSSLSSPPPMAGHSATVHGDRMVVFGGYQ-IKDDFNVNS--- 240
            |       .||||:|...:.|....:..:.|...||||.|.||.|.|:||:. |.::.::.:
 Worm   226 P-------PELHYFDTSTSTWRYVPATGNSPSSIGHSAVVSGDYMFVYGGWPFIHNELHLETPLR 283

  Fly   241 -NDTWVLDLPEQRW-------WQPLFVGNTRPSPRY--GQIQVELGRNHLLIVGGCGGANRVYTD 295
             ....:||:..:.|       |.|   .:..|.||:  .:.::.|.|:.||::.| ....:.|..
 Worm   284 VERLQILDIRHETWKTVQLEKWNP---ADPAPFPRFHTRKTKLILIRDGLLLITG-ELIPQDYGS 344

  Fly   296 AWLL--DMT---RDVWSWKSIAVRNKRFGAVHMW----------CNPGCKVNNY----------- 334
            :.||  |:|   .|.|.||||....:.:|...:.          .||.|.:.|.
 Worm   345 SVLLQYDVTNPLNDTWRWKSIPTIGRWWGRKFLQMEVRGEAVFRLNPECSMPNIEFHQIADVRNE 409

  Fly   335 ----LVVVGPSPNMPQDFQMMKQSRVPVVGGRGPPPPNPLQNVPPRGYRIPVPDRRLGGGGLGGP 395
                ||.:|          .::....|:|........:.:|:    |||
 Worm   410 KMIRLVSLG----------RLRSECAPLVRATFAEEYDAVQS----GYR---------------- 444

  Fly   396 GQNRGGNIRPGVGGAAAALGPQEQYLANRRAILNQHMQQAQQFLHNSNVNNNNN-------NYQP 453
                                       :....|..|::  .::....:.::|:.       |...
 Worm   445 ---------------------------DFARQLKCHLE--MEYKRRIDTSSNDTCAIFKYLNLVC 480

  Fly   454 RSGRLSDLHAPPAAAAAASPPSPPVRPNAPPSPADGDVDAAQRLQ---RNLALRCRDNEPRLPKR 515
            :.|...                  ||...|.:|.......:||..   |::..|.:::||::| |
 Worm   481 KIGGCF------------------VRGKTPSTPTTSSHANSQRFHIHVRSIPRRGQNDEPKMP-R 526

  Fly   516 FDELYEDPFRMAAFNVPTRSRSASRDHNERIRRMEEKMNA-IRNSRRSAPAAAQVEPQPLRAPSP 579
            ||::  |.:.:..                .||.:..:::: ..|:.|....|.:|   |:|..:.
 Worm   527 FDDV--DLWELRC----------------TIRAVLNQLHSKYYNTSRMDYLAPRV---PMRNSAL 570

  Fly   580 KRLRCNVQSLFVCDISGILDSSEPALEWVEYKNFGVLKGAPDRLILSSLIAGNGELILFGGVHKE 644
            |||     |::|.::        |.  .||::.|..|:..|......|.:..:|..::  |.|.:
 Worm   571 KRL-----SVYVAEV--------PC--HVEFEEFDELRWTPQAEQYPSPVDTDGYFLV--GSHHD 618

  Fly   645 TL 646
            .:
 Worm   619 VI 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbxo42	NP_611647.1	F-box_FBXO42	24..61	CDD:438882	9/33 (27%)
		NanM	<101..307	CDD:442289	74/249 (30%)
		KELCH repeat	103..148	CDD:276965	18/65 (28%)
		KELCH repeat	154..209	CDD:276965	20/58 (34%)
		KELCH repeat	212..257	CDD:276965	16/56 (29%)
		KELCH repeat	267..314	CDD:276965	17/53 (32%)
Y50D7A.1	NP_001379295.1	NanM	136..>335	CDD:442289	64/208 (31%)
		KELCH repeat	196..247	CDD:276965	20/57 (35%)
		KELCH repeat	250..300	CDD:276965	15/49 (31%)
		KELCH repeat	315..361	CDD:276965	12/46 (26%)