DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxo42 and KLHDC3

DIOPT Version :10

Sequence 1:NP_611647.1 Gene:Fbxo42 / 37532 FlyBaseID:FBgn0034704 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_476502.1 Gene:KLHDC3 / 116138 HGNCID:20704 Length:382 Species:Homo sapiens


Alignment Length:299 Identity:74/299 - (24%)
Similarity:123/299 - (41%) Gaps:38/299 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LRWEVFS--QQTVNGGAGALLSFIAGRFAHSAVRQDNSMYVFGGGSSSDTTFNDLWRFDLTHMRW 141
            |||....  :..:.|.| .::.::  |:.||.|..|:::.::||.:.::...|.|:.||:...:|
Human    54 LRWTKLPPVKSAIRGQA-PVVPYM--RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKW 115

  Fly   142 ARPVATGTYPSPKGSASMVAWRNQLILFGGWRYPSLHPPYQPWCLFDELHYYDLGKNRWLLRSSL 206
            ..|..:||.|..:...|.......:.:|||:.       .|..|..:::|..|.....|.|..:.
Human   116 FTPRVSGTVPGARDGHSACVLGKIMYIFGGYE-------QQADCFSNDIHKLDTSTMTWTLICTK 173

  Fly   207 SSPPPMAG-HSATVHGDRMVVFGGYQIK-DDFNVNS----NDTWVLDLPEQRWWQ----PLFVGN 261
            .||..... ||||:.|..|.||||...: ..|:.|:    |...|.|...:.|..    |:....
Human   174 GSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEG 238

  Fly   262 TRPSPRYGQIQVELGRNHLLIVGGCGG-ANRVYTDAWLLDMTRDVWSWKSIAVRNKRFGAVHMWC 325
            .|....:|.      ...|.|.||... .||.:.|.|..:...  ::||.|..:.|........|
Human   239 RRSHSAFGY------NGELYIFGGYNARLNRHFHDLWKFNPVS--FTWKKIEPKGKGPCPRRRQC 295

  Fly   326 NPGCKVNNYLVVVG---PSP--NMPQDFQMMKQSRVPVV 359
              .|.|.:.:|:.|   |||  .:..:|.::..|.:.::
Human   296 --CCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHIL 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxo42NP_611647.1 F-box_FBXO42 24..61 CDD:438882
NanM <101..307 CDD:442289 55/216 (25%)
KELCH repeat 103..148 CDD:276965 13/44 (30%)
KELCH repeat 154..209 CDD:276965 10/54 (19%)
KELCH repeat 212..257 CDD:276965 16/54 (30%)
KELCH repeat 267..314 CDD:276965 12/47 (26%)
KLHDC3NP_476502.1 NanM 14..308 CDD:442289 68/273 (25%)
KELCH repeat 14..62 CDD:276965 3/7 (43%)
Kelch 1 25..77 5/25 (20%)
KELCH repeat 77..122 CDD:276965 13/44 (30%)
Kelch 2 88..138 12/49 (24%)
KELCH repeat 128..173 CDD:276965 10/51 (20%)
Kelch 3 139..189 15/56 (27%)
KELCH repeat 180..236 CDD:276965 17/55 (31%)
Kelch 4 191..249 14/63 (22%)
KELCH repeat 239..283 CDD:276965 13/51 (25%)
Kelch 5 251..301 15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

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