DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3045 and PUS3

DIOPT Version :9

Sequence 1:	NP_611646.1	Gene:	CG3045 / 37531	FlyBaseID:	FBgn0034703	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_112597.4	Gene:	PUS3 / 83480	HGNCID:	25461	Length:	481	Species:	Homo sapiens

Alignment Length:	477	Identity:	189/477 - (39%)
Similarity:	265/477 - (55%)	Gaps:	68/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AYNFQLRNLLQKKLSEKDKHDKEYSGLIGNEAEGKV-SQVAKTSSKVQKI-RKFDWSSAHKRHVL 102
            |||...||..:|.|....:.::|...|...:|:.|. |.:.:.|:...|. |.||:|:..:|||.
Human     2 AYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAHGRRHVA 66

  Fly   103 LKITYFGWDYQGFACQEDSNDTIESNLFRALARTCLIESRATSNYHRCGRTDKEVSAFCQVISID 167
            |:|.|.||.|||||.||::|:|||..||.||.:|.|:|||.||||||||||||.||||.||||:|
Human    67 LRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLD 131

  Fly   168 LRSKHPP-------ESQLDPTALSSEIDYCGLLNRVLPKNIQCVAWMPLRSPVYSARFDCVSRTY 225
            |||:.|.       ..:.:..|.:.||.|..:||||||.:|:.:||.|: .|.:||||.|:.|||
Human   132 LRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV-EPSFSARFSCLERTY 195

  Fly   226 RYYFPKGDLDIAAMRKACDLLVRHADFRNFCKMDVHNGVTNYMRNLQSARVEACDQT---NHTNS 287
            ||:||:.||||..|..|....|...||||.|||||.|||.|:.|.:.||:|:...|:   .....
Human   196 RYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQE 260

  Fly   288 GYDMYYLEIQANAFLWHQIRCIMAVLLLVGQKKENPGVISDLLDVESNPCKPQYTPAIGLPLNLF 352
            .:.:...|:...|||:||:||:||:|.|:||..|.|.:|.:||::|.||.||||:.|:..||.|:
Human   261 PFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLY 325

  Fly   353 RCDFRDHTTRSVNHPSSGDADEEAMDTAADESNDLNAPEHLERDLTAWIYNEENLQKLIENTQCE 417
            .|.|.:                                       ..|||::|..:..|.:.|..
Human   326 DCKFEN---------------------------------------VKWIYDQEAQEFNITHLQQL 351

  Fly   418 WTQFSVKSTMIRNVLQQLENL------------FEE--NFKPKEKVLAQVILLQDSVNPRQYQPL 468
            |...:||:.|:.::||.|:.:            ..|  |.||  .|:.|.....:.|..|.|:||
Human   352 WANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKP--SVIKQTSAFVEGVKMRTYKPL 414

  Fly   469 LERKRCESLENRIEHFVKKQRL 490
            ::|.:|:.||:||:|||::.|:
Human   415 MDRPKCQGLESRIQHFVRRGRI 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3045	NP_611646.1	TruA	101..376	CDD:223179	135/284 (48%)
CG3045	NP_611646.1	PseudoU_synth_ScPus3	103..356	CDD:211336	133/262 (51%)
PUS3	NP_112597.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50		4/20 (20%)
PUS3	NP_112597.4	PseudoU_synth_ScPus3	67..329	CDD:211336	133/262 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147959
Domainoid	1	1.000	186	1.000	Domainoid score	I3371
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11339
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2519
Isobase	1	0.950	-	0	Normalized mean entropy	S1490
OMA	1	1.010	-	-		QHG54236
OrthoDB	1	1.010	-	-		D1093493at2759
OrthoFinder	1	1.000	-	-		FOG0004137
OrthoInspector	1	1.000	-	-		oto90615
orthoMCL	1	0.900	-	-		OOG6_100424
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1941
SonicParanoid	1	1.000	-	-		X2401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750