DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmr1 and FXR1

DIOPT Version :9

Sequence 1:	NP_001247017.1	Gene:	Fmr1 / 37528	FlyBaseID:	FBgn0028734	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_005247870.2	Gene:	FXR1 / 8087	HGNCID:	4023	Length:	677	Species:	Homo sapiens

Alignment Length:	722	Identity:	267/722 - (36%)
Similarity:	394/722 - (54%)	Gaps:	86/722 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFV--DVDGVPESMKYPFVNVRLPPEETVEVAAPIFEE 111
            |.:|.||||..|||:|||.:..|.:|.:.|  :.:..|| .:.||..|||||...::..   ..|
Human     1 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPE-RQVPFNEVRLPPPPDIKKE---ISE 61

  Fly   112 GMEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPITAKTF 176
            |.||||::|.||:|.||||:..::|.|.|.|.:.|...:.:|.||....|||..|.|..:...||
Human    62 GDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTF 126

  Fly   177 YQFTLPVPEELREEAQKDGIHKEFQRTIDAGVCN--YSRDLDALIVISKFEHTQKRASMLKDMHF 239
            ::.|:.|||:|||....:..||:|::.:  |.|.  |..:...|:::|..|.|.||.::|.|||.
Human   127 FKCTVDVPEDLREACANENAHKDFKKAV--GACRIFYHPETTQLMILSASEATVKRVNILSDMHL 189

  Fly   240 RNLSQKVMLLKRTEEAARQLETTKLMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDGVTNI 304
            |::..|:||:.|.|||.:.||.||.::.. :.|||.||:||||||||:||||||.||.|.|||.|
Human   190 RSIRTKLMLMSRNEEATKHLECTKQLAAA-FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAI 253

  Fly   305 ELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVFRIKI 369
            ||:|.:.||:|.||:.::|::||..||:.|:|.||||.||||||||||::||||||||||.|::|
Human   254 ELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRI 318

  Fly   370 AGDDEQDQNIPRELAHVPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAIQES 434
            .||:|  ..:|||...|||||:||.|||.|.:||||||:::||||||||.|:::||:|||.|
Human   319 EGDNE--NKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQI--- 378

  Fly   435 SMGSTQSFPVTRRSERGYSSDIESVRSMRGGGGGQRGRVRGRGGGGPGGGNGLNQRYHN------ 493
            .||...|.......|:||::|..:|.|:: |.....||.|||.|.....|.|.|....|
Human   379 GMGFRPSSTRGPEKEKGYATDESTVSSVQ-GSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETES 442

  Fly   494 NRRD---------EDDYNSRGDHQRDQQRGYNDRGGGDNTGSYRGGGGGAGGPGNNRRGG----- 544
            .|:|         |||.:||  ||||.:|    |.||  .|....||.|.|||    |||
Human   443 ERKDELSDWSLAGEDDRDSR--HQRDSRR----RPGG--RGRSVSGGRGRGGP----RGGKSSIS 495

  Fly   545 -INRRPPRNDQQNGRDYQHHNHTTEEVRETREMSSVERADSNSSYEGSSRRRRRQKNN------- 601
             :.:.|..|..              .:.:..|.......|::.|:..::||||.::..
Human   496 SVLKDPDSNPY--------------SLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVL 546

  Fly   602 -NGPSNTNGAVANNNNKPQSAQQPQQQQPPAPGNKAALNAGDASKQNSGNANAAGGASKPKDAS- 664
             :|.:.::.|..|.|....|.::||::      |::.........::......|...|:.:..|
Human   547 MDGMTESDTASVNENGLDDSEKKPQRR------NRSRRRRFRGQAEDRQPVTVADYISRAESQSR 605

  Fly   665 -RNGDKQQAGTQQQQPSQ--VQQQQAAQQQQPKPRRNKNRSNNHTDQPSGQQQL----AENVKKE 722
             ||..::.....:::.::  :::...:::....|........:...:..|::::    .||.::.
Human   606 QRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEA 670

  Fly   723 GLVNGTS 729
            .::||.|
Human   671 AVLNGVS 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmr1	NP_001247017.1	Agenet	107..163	CDD:214798	23/55 (42%)
		KH_1	271..330	CDD:278442	37/58 (64%)
		KH_1	337..404	CDD:278442	44/66 (67%)
		FXMRP1_C_core	407..528	CDD:289039	52/135 (39%)
FXR1	XP_005247870.2	Tudor_Agenet_FXR1_rpt1	3..57	CDD:410543	23/54 (43%)
		Tudor_Agenet_FXR1_rpt2	61..126	CDD:410546	27/64 (42%)
		KH-I	123..199	CDD:412160	28/77 (36%)
		KH-I	218..280	CDD:412160	37/62 (60%)
		KH-I	281..358	CDD:412160	51/78 (65%)
		FXMRP1_C_core	354..465	CDD:403448	44/116 (38%)
		FXR_C1	491..564	CDD:406490	13/86 (15%)
		FXR_C3	610..676	CDD:406491	5/65 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158212
Domainoid	1	1.000	88	1.000	Domainoid score	I7941
eggNOG	1	0.900	-	-		E1_2C9YP
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	385	1.000	Inparanoid score	I2044
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002239
OrthoInspector	1	1.000	-	-		otm41158
orthoMCL	1	0.900	-	-		OOG6_102557
Panther	1	1.100	-	-	O	PTHR10603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4572
SonicParanoid	1	1.000	-	-		X1481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780