DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmr1 and fmr1

DIOPT Version :9

Sequence 1:	NP_001247017.1	Gene:	Fmr1 / 37528	FlyBaseID:	FBgn0028734	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001005454.1	Gene:	fmr1 / 448049	XenbaseID:	XB-GENE-977113	Length:	590	Species:	Xenopus tropicalis

Alignment Length:	607	Identity:	246/607 - (40%)
Similarity:	341/607 - (56%)	Gaps:	76/607 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFVDVD-GVPESMKYPFVNVRLPPEETVEVAAPIFEEG 112
            ||:|.||||..|||:||..|..|.:|.|.|..: ...:..:.||.:||.||.....   ....|.
Frog     1 MEELAVEVRGSNGAFYKAFVKDVHEDSITVTFENNWQQERQIPFHDVRFPPPSGYN---KDINES 62

  Fly   113 MEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPITAKTFY 177
            .||||::|.|::|.|.||:..::|.|.|.|.:.|...:.:|.||..:.|||:.|.|.|.|..:|:
Frog    63 DEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKNSFH 127

  Fly   178 QFTLPVPEELREEAQKDGIHKEFQRTIDAGVCNYSRDLDALIVISKFEHTQKRASMLKDMHFRNL 242
            :..|.|||:||:...||..||:|::.:.|...:|..:...|:::|..|.|.|||:||.|||||:|
Frog   128 KVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDSENYQLVILSVNEVTIKRANMLSDMHFRSL 192

  Fly   243 SQKVMLLKRTEEAARQLETTK-LMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDGVTNIEL 306
            ..|:.|:.|.|||::|||::: |.||  :.|:|.||:||||||||:||:|||.||.|.|||.|:|
Frog   193 RTKLSLMLRNEEASKQLESSRQLASR--FHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDL 255

  Fly   307 EEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVFRIKIAG 371
            :|.:|||.|.||.:|:|::||..||:||:..||||.||||||||||::||||||||||.|::|
Frog   256 DEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRI-- 318

  Fly   372 DDEQDQNIPRELAHVPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAIQESSM 436
            :.|.|:||..|...|||||:||.:||.||.|||:|||::||||:|||.|:::||:|||.|..||.
Frog   319 EAENDKNISPEEGMVPFVFVGTKDSITNATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSR 383

  Fly   437 GSTQSFPVTRR--SERGYSSDIESVRSMRGGGGGQR---GRVRGRGGGGPGGG------------ 484
                  |...|  .|:||.|:     .:.|.|.|.|   .|.|.|.|.|....
Frog   384 ------PPPNRPDKEKGYQSE-----DLSGTGRGSRPYNNRGRSRRGTGYASDIRYGDPDYRKTT 437

  Fly   485 ------------NGLNQRYHNNRRDEDDYNSR-GDHQ----RDQQRGYNDRGGGDNTGSYRGGG- 531
                        .|.|....|....|.|:... .|..    .|.:..|:.||.|...|..||.|
Frog   438 YPEYPRSQAFWIKGTNSEASNASETESDHRDELSDWSLAPAEDDRDNYHRRGDGRRRGGPRGQGM 502

  Fly   532 -GGAGGPGNNRRGGINRRPPRNDQQNGRDYQHHNHTTEEVRETR-----EMSSVERADSNSSYEG 590
             |..|..||:     ::..|.|.|:|.|:.:  ..|::...:.|     |.|...:...|:|.||
Frog   503 RGRGGFKGND-----DQPRPDNRQRNSRETK--ARTSDGSLQIRIDCNNERSVHTKTLQNASVEG 560

  Fly   591 S------SRRRRRQKNN--NGP 604
            |      .|.::::|:.  :||
Frog   561 SRLRTGKDRVQKKEKSEVVDGP 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmr1	NP_001247017.1	Agenet	107..163	CDD:214798	20/55 (36%)
		KH_1	271..330	CDD:278442	36/58 (62%)
		KH_1	337..404	CDD:278442	43/66 (65%)
		FXMRP1_C_core	407..528	CDD:289039	45/154 (29%)
fmr1	NP_001005454.1	Tudor_FRX1	4..52	CDD:375763	20/47 (43%)
		KH_9	123..207	CDD:375417	35/83 (42%)
		KH	221..280	CDD:197652	36/58 (62%)
		KH_1	285..351	CDD:365809	43/67 (64%)
		FXMRP1_C_core	354..485	CDD:371981	40/141 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..438		19/72 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..590		36/137 (26%)
		RNA-binding RGG-box. /evidence=ECO:0000255	494..507		5/12 (42%)
		FXMR_C2	508..590	CDD:374363	20/82 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7866
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1531
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2044
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4572
SonicParanoid	1	1.000	-	-		X1481
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090