DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fmr1 and FMR1

DIOPT Version :9

Sequence 1:NP_001247017.1 Gene:Fmr1 / 37528 FlyBaseID:FBgn0028734 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002015.1 Gene:FMR1 / 2332 HGNCID:3775 Length:632 Species:Homo sapiens


Alignment Length:678 Identity:255/678 - (37%)
Similarity:348/678 - (51%) Gaps:154/678 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFVDVDG--VPESMKYPFVNVRLPPEETVEVAAPI--- 108
            ||:|:||||..|||:||..|..|.:|.|.|..:.  .|: .:.||.:||.||        |:   
Human     1 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPD-RQIPFHDVRFPP--------PVGYN 56

  Fly   109 --FEEGMEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPI 171
              ..|..||||::|.|::|.|.||:..::|.|.|.|.:.|...:.:|.||..:.|||:.|.|.|.
Human    57 KDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPA 121

  Fly   172 TAKTFYQFTLPVPEELREEAQKDGIHKEFQRTIDAGVCNYSRDLDALIVISKFEHTQKRASMLKD 236
            |..||::..|.|||:||:...|:..||:|::.:.|....|..:...|:::|..|.|.|||.||.|
Human   122 TKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLID 186

  Fly   237 MHFRNLSQKVMLLKRTEEAARQLETTK-LMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDG 300
            ||||:|..|:.|:.|.|||::|||::: |.||  :.|:|.||:||||||||:||:|||.||.|.|
Human   187 MHFRSLRTKLSLIMRNEEASKQLESSRQLASR--FHEQFIVREDLMGLAIGTHGANIQQARKVPG 249

  Fly   301 VTNIELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVF 365
            ||.|:|:|.:|||.|.||.:::|::||:.||:||:..||||.||||||||||::||||||||||.
Human   250 VTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVV 314

  Fly   366 RIKIAGDDEQD---------------------QNIPRELAH------------------------ 385
            |::|..::|::                     .|.|.|..|                        
Human   315 RVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVA 379

  Fly   386 -------------------VPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAI 431
                               |||||:||.:|||||.|||:|||::||||:|||.|:::||:|||.|
Human   380 SSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQI 444

  Fly   432 QESSMGSTQSFPVTRRS--ERGYSSDIESVRSMRGGGGGQRG-RVRGRGGGGPGGGNGLNQRYHN 493
            ..||.      |...|:  |:.|.:|     ..:|.|.|.|. |.||.|..|||..:|.|....|
Human   445 GASSR------PPPNRTDKEKSYVTD-----DGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASN 498

  Fly   494 NRRDEDDYNS-------------------RGDHQRDQQRGYNDRGGGDNTGSYRGGGGGAGG-PG 538
            ....|.|:..                   |||.:|        ||||   |..:||.|..|| .|
Human   499 ASETESDHRDELSDWSLAPTEEERESFLRRGDGRR--------RGGG---GRGQGGRGRGGGFKG 552

  Fly   539 NNRRGGINRRPPRNDQQNGRDYQHHNHTTEEVRETR-----EMSSVERADSNSSYEGSSRRRRRQ 598
            |:.....:.||....:..||       ||:...:.|     |.|...:...|:|.|||..|..:.
Human   553 NDDHSRTDNRPRNPREAKGR-------TTDGSLQIRVDCNNERSVHTKTLQNTSSEGSRLRTGKD 610

  Fly   599 KNNNGPSNTNGAVANNNNKPQS--AQQP 624
            :|            ....||.|  .|||
Human   611 RN------------QKKEKPDSVDGQQP 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fmr1NP_001247017.1 Agenet 107..163 CDD:214798 21/60 (35%)
KH_1 271..330 CDD:278442 35/58 (60%)
KH_1 337..404 CDD:278442 44/130 (34%)
FXMRP1_C_core 407..528 CDD:289039 48/142 (34%)
FMR1NP_002015.1 Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:P35922 1..184 72/191 (38%)
Agenet 63..120 CDD:283330 23/56 (41%)
Necessary for interaction with CYFIP1, CYFIP2, FXR1 and FXR2. /evidence=ECO:0000250|UniProtKB:P35922, ECO:0000269|PubMed:14532325, ECO:0000269|PubMed:8668200 172..211 22/38 (58%)
KH 221..280 CDD:197652 35/58 (60%)
KH_1 283..>325 CDD:278442 28/41 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..349 0/23 (0%)
Required for nuclear export. /evidence=ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:8789445 397..491 50/104 (48%)
Interaction with RANBP9. /evidence=ECO:0000269|PubMed:15381419 419..632 78/249 (31%)
FXMRP1_C_core 420..572 CDD:289039 57/173 (33%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35922 424..443 12/18 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..632 62/225 (28%)
Nucleolar localization signal 1. /evidence=ECO:0000269|PubMed:24658146 527..534 4/14 (29%)
RNA-binding RGG-box 534..548 8/16 (50%)
FXMR_C2 550..632 CDD:292716 24/96 (25%)
Nucleolar localization signal 2. /evidence=ECO:0000269|PubMed:24658146 613..617 0/3 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158213
Domainoid 1 1.000 82 1.000 Domainoid score I8405
eggNOG 1 0.900 - - E1_2C9YP
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1531
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002239
OrthoInspector 1 1.000 - - otm41158
orthoMCL 1 0.900 - - OOG6_102557
Panther 1 1.100 - - O PTHR10603
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1481
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.700

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