DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fmr1 and Fxr1

DIOPT Version :10

Sequence 1:NP_001247017.1 Gene:Fmr1 / 37528 FlyBaseID:FBgn0028734 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001106659.1 Gene:Fxr1 / 14359 MGIID:104860 Length:677 Species:Mus musculus


Alignment Length:716 Identity:270/716 - (37%)
Similarity:382/716 - (53%) Gaps:115/716 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFV--DVDGVPESMKYPFVNVRLPPEETVEVAAPIFEE 111
            |.:|.||||..|||:|||.:..|.:|.:.|  :.:..|| .:.||..|||||...::..   ..|
Mouse     1 MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPE-RQVPFNEVRLPPPPDIKKE---ISE 61

  Fly   112 GMEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPITAKTF 176
            |.||||::|.||:|.||||:..::|.|.|.|.:.|...:.:|.||....|||..|.|..:...||
Mouse    62 GDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTF 126

  Fly   177 YQFTLPVPEELREEAQKDGIHKEFQRTIDAGVCN--YSRDLDALIVISKFEHTQKRASMLKDMHF 239
            ::.|:.|||:|||....:..||:|::.:  |.|.  |..:...|:::|..|.|.||.::|.|||.
Mouse   127 FKCTVDVPEDLREACANENAHKDFKKAV--GACRIFYHPETTQLMILSASEATVKRVNILSDMHL 189

  Fly   240 RNLSQKVMLLKRTEEAARQLETTKLMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDGVTNI 304
            |::..|:||:.|.|||.:.||.||.::.. :.|||.||:||||||||:||||||.||.|.|||.|
Mouse   190 RSIRTKLMLMSRNEEATKHLECTKQLAAA-FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAI 253

  Fly   305 ELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVFRIKI 369
            ||:|.:.||:|.||:.|:|::||..||:.|:|.||||.||||||||||::||||||||||.|::|
Mouse   254 ELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRI 318

  Fly   370 AGDDEQDQNIPRELAHVPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAIQES 434
            .||:|  ..:|||...|||||:||.|||.|.:||||||:::||||||||.|:::||:|||.|   
Mouse   319 EGDNE--NKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQI--- 378

  Fly   435 SMGSTQSFPVTRRSERGYSSDIESVRSMRGGGGGQRGRVRGRGGGGPGGGNGLNQRYHN------ 493
            .||...|.......|:||::|..:|.|:: |.....||.|||.|.....|.|.|....|      
Mouse   379 GMGFRPSSTRGPEREKGYATDESTVSSVQ-GSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETES 442

  Fly   494 NRRDE-DDYNSRGD------HQRDQQRGYNDRGGGDNTGSYRGGGGGAGGPGNNRRGG------I 545
            .|:|| .|::..|:      ||||.:|    |.||  .|....||.|.|||    |||      :
Mouse   443 ERKDELSDWSLAGEDDRETRHQRDSRR----RPGG--RGRSVSGGRGRGGP----RGGKSSISSV 497

  Fly   546 NRRPPRNDQQNGRDYQHHNHTTEEVRETREMSSVERADSNSSYEGSSRRRRRQKNN--------N 602
            .:.|..|..              .:.:..|.......|::.|:..::||||.::..        :
Mouse   498 LKDPDSNPY--------------SLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMD 548

  Fly   603 GPSNTNGAVANNNNKPQSAQQPQQQQPPAPGNKAALNAGDASKQNSGNANAAGGASKPKDASRNG 667
            |.:.::.|..|.|....|.::||::      |:                           :.|..
Mouse   549 GLTESDTASVNENGLDDSEKKPQRR------NR---------------------------SRRRR 580

  Fly   668 DKQQAGTQQQQPSQV------QQQQAAQQQQPKPRRNKNRSNNHTDQPSGQQQLAENVKKEGLVN 726
            .:.||  :.:||..|      .:.|:.|:..|:....||:.....|      .:.|:...|..:|
Mouse   581 FRGQA--EDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKD------VIEEHGPSEKAIN 637

  Fly   727 G 727
            |
Mouse   638 G 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fmr1NP_001247017.1 Tudor_Agenet_FMRP-like_rpt1 51..99 CDD:410473 22/49 (45%)
Tudor_SF 111..176 CDD:470623 27/64 (42%)
KH_I_FMR1_FXR_rpt1 173..249 CDD:411853 28/77 (36%)
KH_I_FMR1_FXR_rpt2 270..331 CDD:411854 38/60 (63%)
KH_I_FMR1_FXR_rpt3 332..411 CDD:411855 51/78 (65%)
FXMRP1_C_core 407..>455 CDD:463501 22/47 (47%)
Fxr1NP_001106659.1 Tudor_Agenet_FXR1_rpt1 3..57 CDD:410543 23/54 (43%)
Tudor_Agenet_FXR1_rpt2 61..126 CDD:410546 27/64 (42%)
KH_I_FXR1_rpt1 123..199 CDD:411932 28/77 (36%)
CC1 domain. /evidence=ECO:0000250|UniProtKB:P51114 201..208 4/6 (67%)
KH_I_FXR1_rpt2 218..280 CDD:411935 38/62 (61%)
KH_I_FXR1_rpt3 281..358 CDD:411938 51/78 (65%)
CC2 domain. /evidence=ECO:0000250|UniProtKB:P51114 353..379 17/28 (61%)
FXMRP1_C_core 354..467 CDD:463501 44/116 (38%)
Disordered. /evidence=ECO:0000269|PubMed:35951695 380..677 76/325 (23%)
RNA-binding RGG-box 471..486 6/16 (38%)
FXR_C1 491..564 CDD:465019 13/86 (15%)
FXR_C3 610..676 CDD:435134 8/35 (23%)

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