DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmr1 and Fmr1

DIOPT Version :9

Sequence 1:	NP_001247017.1	Gene:	Fmr1 / 37528	FlyBaseID:	FBgn0028734	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_032057.2	Gene:	Fmr1 / 14265	MGIID:	95564	Length:	614	Species:	Mus musculus

Alignment Length:	654	Identity:	252/654 - (38%)
Similarity:	345/654 - (52%)	Gaps:	124/654 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MEDLLVEVRLDNGAYYKGQVTAVADDGIFVDVDG--VPESMKYPFVNVRLPPEETVEVAAPI--- 108
            ||:|:||||..|||:||..|..|.:|.|.|..:.  .|| .:.||.:||.||        |:
Mouse     1 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPE-RQIPFHDVRFPP--------PVGYN 56

  Fly   109 --FEEGMEVEVFTRTNDRETCGWWVGIIKMRKAEIYAVAYIGFETSYTEICELGRLRAKNSNPPI 171
              ..|..||||::|.|::|.|.||:..::|.|.|.|.:.|...:.:|.||..:.|||:.|.|.|.
Mouse    57 KDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPA 121

  Fly   172 TAKTFYQFTLPVPEELREEAQKDGIHKEFQRTIDAGVCNYSRDLDALIVISKFEHTQKRASMLKD 236
            |..||::..|.|||:||:...|:..||:|::.:.|....|..:...|:::|..|.|.|||.||.|
Mouse   122 TKDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLID 186

  Fly   237 MHFRNLSQKVMLLKRTEEAARQLETTK-LMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVDG 300
            ||||:|..|:.|:.|.|||::|||::: |.||  :.|:|.||:||||||||:||:|||.||.|.|
Mouse   187 MHFRSLRTKLSLILRNEEASKQLESSRQLASR--FHEQFIVREDLMGLAIGTHGANIQQARKVPG 249

  Fly   301 VTNIELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIGKNGRIIQEIVDKSGVF 365
            ||.|:|:|.:|||.|.||.:::|::||:.||:||:..||||.||||||||||::||||||||||.
Mouse   250 VTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVV 314

  Fly   366 RIKIAGDDE----QDQNI-------------------------PRELAH---------------- 385
            |::|..::|    |::.|                         .:|..|
Mouse   315 RVRIEAENEKSVPQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKENTHFSQPNSTKVQRVLVVS 379

  Fly   386 ------------------VPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRAIQ 432
                              |||||:||.:|||||.|||:|||::||||:|||.|:::||:|||.|.
Mouse   380 SIVAGGPQKPEPKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIG 444

  Fly   433 ESSMGSTQSFPVTRRS--ERGYSSDIESVRSMRGGGGGQRG-RVRGRGGGGPGGGNGLNQRYHNN 494
            .||.      |...|:  |:||.:|     ..:|.|.|.|. |.||.|..|||..:|.|....|.
Mouse   445 ASSR------PPPNRTDKEKGYVTD-----DGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNA 498

  Fly   495 RRDEDDYNSR-GDHQ----RDQQRGYNDRGGGDNTGSYRGGGGGAGGPGNNRRGGINRRPPRNDQ 554
            ...|.|:... .|..    .:::..:..||.|     .|.||||.|..|..|.||.
Mouse   499 SETESDHRDELSDWSLAPTEEERESFLRRGDG-----RRRGGGGRGQGGRGRGGGF--------- 549

  Fly   555 QNGRDYQHHNHTTEEVRETREMSSVERAD---SNSSYEGSSRRRRRQKN--NNGPSNTNGAVANN 614
             .|.|  .|:.|....|..||... ..||   .::|.|||..|..:.:|  ...|.:.:|.....
Mouse   550 -KGND--DHSRTDNRPRNPREAKG-RTADGSLQSASSEGSRLRTGKDRNQKKEKPDSVDGLQPLV 610

  Fly   615 NNKP 618
            |..|
Mouse   611 NGVP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmr1	NP_001247017.1	Agenet	107..163	CDD:214798	21/60 (35%)
		KH_1	271..330	CDD:278442	35/58 (60%)
		KH_1	337..404	CDD:278442	44/129 (34%)
		FXMRP1_C_core	407..528	CDD:289039	44/128 (34%)
Fmr1	NP_032057.2	Required for nuclear localization. /evidence=ECO:0000269\|PubMed:8842725	1..184		72/189 (38%)
		Agenet	63..120	CDD:283330	23/56 (41%)
		Necessary for interaction with CYFIP1, CYFIP2, FXR1 and FXR2. /evidence=ECO:0000250\|UniProtKB:Q06787, ECO:0000269\|PubMed:11438699	172..211		20/38 (53%)
		KH	221..280	CDD:197652	34/58 (59%)
		KH_1	283..>323	CDD:278442	29/39 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..369		27/108 (25%)
		Required for nuclear export. /evidence=ECO:0000250\|UniProtKB:Q06787	396..490		31/101 (31%)
		Interaction with RANBP9. /evidence=ECO:0000250\|UniProtKB:Q06787	418..614		48/164 (29%)
		FXMRP1_C_core	419..571	CDD:289039	47/163 (29%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:8842725	423..442		9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..614		36/139 (26%)
		Nucleolar localization signal 1. /evidence=ECO:0000250\|UniProtKB:Q06787	526..533		2/6 (33%)
		RNA-binding RGG-box	534..547		6/15 (40%)
		FXMR_C2	549..614	CDD:292716	5/24 (21%)
		Nucleolar localization signal 2. /evidence=ECO:0000250\|UniProtKB:Q06787	595..599

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848593
Domainoid	1	1.000	82	1.000	Domainoid score	I8398
eggNOG	1	0.900	-	-		E1_2C9YP
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1531
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1866
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002239
OrthoInspector	1	1.000	-	-		otm43229
orthoMCL	1	0.900	-	-		OOG6_102557
Panther	1	1.100	-	-	O	PTHR10603
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4572
SonicParanoid	1	1.000	-	-		X1481
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780