Protein Alignment GM130 and GOLGA6L7

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001352300.1
• Gene: GOLGA6L7 / 728310
• HGNCID: 37442
• Length: 622
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 124/645 - (19%)
• Similarity: 264/645 - (40%)
• Gaps: 139/645 - (21%)

  Fly     1 MPDDTQDAKAQKLAAARKKLKEYQQRASNNNGQPGAEEPVAATTQSHSSTVSISSNLSERSDSEI 65
            |.:.||.   :|||..:||..:|.|..|...|        ...|.:....::..:| .|.:.|
Human     2 MSEKTQQ---RKLAGTKKKFTDYHQWNSAGVG--------TGATDTKKKKINHGAN-PETTTS-- 52

  Fly    66 NVNGGGAGGTQPPEQSALPTAASYFAQNESEHNGGLADASSLQA----IQVIIAEKAQLNAELTK 126
                   ||...||... ...|....:|::.|....|....|:|    |::::.:|.:|...|..
Human    53 -------GGCHSPEDKQ-QNRAQLKEENKASHQHQQALRRQLEAQDHTIRILMCQKTELETALHD 109

  Fly   127 VRLACRERELELEEL---------------------------------RILKDQNQLRLEQLQQH 158
            .:.|.|:.|.:.::|                                 .:.|::..:.||..:..
Human   110 SQDAARKFEEDSKDLAARLHHSWHFAGELQRALSAMSAEHERADKYIKELTKEREAMSLELFRNI 174

  Fly   159 CQDQQSTGEQQRQQYAQLQAQLLQSQAQIKDQQSHLNELEAQLK---------QSNQHQEELQQQ 214
            .     |.::.:::.|:||.:|...:.:..:.|.|:.||:.:|:         |:|..||::.:|
Human   175 I-----TNKELKEKNAELQEKLRLVETEKSEIQLHIKELKRKLETDKIPLPQVQTNTLQEKMWRQ 234

  Fly   215 LSQKSNELEMA-QLKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRD----LQAMVGQLTQDKEQ 274
            ..:..::.|:. |.|||:..::               .:..||::||    |:....|:.:.:||
Human   235 EEELRDQEELRDQEKLRKHEEK---------------MWRQEQRLRDQEKELREQEQQMQEQEEQ 284

  Fly   275 AAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEHVGALE----------RDIQKNI 329
            ...| :..::.|..::.|..|:..:..|.:....|:.|:..|.:|..|          |..:|.:
Human   285 MRKQ-EEQMRKQEEQMRKQEEQMRKQEEQMRKQEEQMRKQEEQMGKQEEQMGEQEEQMRKQEKQM 348

  Fly   330 SLQAQ--FKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQDDQLQLKNSA 392
            ..|.:  .|:..|:...:|:..||   ::::...:||:...|.:..|.:.:::.|::|:..:...
Human   349 LKQKEQMRKQEEQMWKQEEQIGEQ---EEQMRKQEEQMWKQEEQIGEQEEQMRKQEEQMWKQEEQ 410

  Fly   393 LDELEKQLERLQAEQPDQSKLLATMESDKVAASRALTQNVEMKNQLDELQQRFVQLTNDKAELVI 457
            :.|..::.|....||.:|.:.......::....|  .|..:|..|.::::::..|:...:.::
Human   411 MGEQMRKQEEQMGEQEEQIRKQEEQMGEQEEQMR--KQEEQMGEQEEQMRKQEEQMGEQEEQM-- 471

  Fly   458 RLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHENVELQRQQLMLQQQLDRLRHYE 522
            |...|:...:|  :.....|::::...||.:||:|   ||..|..::|.::..:::|:::.|.
Human   472 RKQEEQMGEQE--EQMGEQEEQMRKQVERLQFKEE---RLWDEYEKMQEEEEKIRRQVEKRRE-- 529

  Fly   523 AKAYHAGEETEKENGADAPENEAEEAKE---------VGLLHNHSHDHSHQHSDGHCHDN 573
                      :||...:..:.:.|...|         ..:.|..|.:.:.:...|:.|||
Human   530 ----------KKERMGEQEKTQEERCSEPCLPPSKYPSDMSHPGSLEPAREAGKGYSHDN 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	67/359 (19%)
		GOLGA2L5	267..725	CDD:464485	62/328 (19%)
GOLGA6L7	NP_001352300.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		23/101 (23%)
		PTZ00121	<114..>544	CDD:173412	85/474 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..496		47/269 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..580		13/81 (16%)
		GM130_C	576..613	CDD:465957	3/4 (75%)