Protein Alignment GM130 and GOLGA6D

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001138696.1
• Gene: GOLGA6D / 653643
• HGNCID: 32204
• Length: 693
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 195/831 - (23%)
• Similarity: 329/831 - (39%)
• Gaps: 224/831 - (26%)

  Fly     6 QDAKAQKLAAARKKLKEYQQRASNNNGQPGAEEPVAATTQSHSSTVSISSNLSERSDS--EINVN 68
            ::::..|||||:|||||||||.|     ||.  |..|.|:            .:::||  |...:
Human    15 EESRQNKLAAAKKKLKEYQQRKS-----PGI--PAGAKTK------------KKKTDSSPETTTS 60

  Fly    69 GGG--AGGTQPPEQSALPTAASYFAQNESEHNGGLADASSLQAIQVIIAEKAQLNAELTKVRLAC 131
            |||  .|.:|..|.                       |.:|::..|.|   .|||..:..::...
Human    61 GGGHSPGDSQYQEL-----------------------AVALESSSVTI---NQLNENIESLKQQK 99

  Fly   132 RERELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQLQAQLLQSQAQIKDQQSHLNE 196
            ::.|.:|||.:  |..|::...|:     :|..|......:.|.|:..|..::...:..:....:
Human   100 KQVEHQLEEAK--KTNNEIHKAQM-----EQLETINILTLEKADLKTTLYHTKRAARHFEEESKD 157

  Fly   197 LEAQLKQSNQHQEELQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRD- 260
            |..:|:.|.||.:||::.|...|.:        :|..|.||...    |:::|.:  .:|.|::
Human   158 LAGRLQYSLQHIQELERALCAVSTQ--------QQEEDRSSSCR----EAVLQRR--LQQTIKER 208

  Fly   261 --LQAMVGQLTQDKEQAAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEHVGALER 323
              |.|.|.|:|:..:|...:...|.:|..||.|:..||..::|....:|:|.:::.:..:..|||
Human   209 ALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELER 273

  Fly   324 DIQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQDDQLQL 388
            .:.:   |:.|..|...:.| ...||..:.|:||...|::::|..|.       |::||.:
Human   274 SLSE---LKNQMAEPPSLAP-PAVTSVVEQLQDEAKHLRQEVEGLEG-------KLQSQVE---- 323

  Fly   389 KNSALDELEK-QLERLQAEQPDQSKLLATMESDKV-AASRALTQNVEMKNQLDELQQRFVQLTND 451
            .|.||..|.| |.:|||    :|.::|...|:.:| ...|...||..::.|...||::..:|...
Human   324 NNQALSLLSKEQKQRLQ----EQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384

  Fly   452 KAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHENVELQRQQLMLQQ--Q 514
            :..|           |:..:.....|::||..|:|. :..||.:....|.::.|.::|.|.|  :
Human   385 EQRL-----------RKQEERLRKEEERLQKQEKRL-WDQEERLWKKEERLQKQEERLALSQNHK 437

  Fly   515 LDRLRHYEAKAYHAGEETEKENGADAPENEAEEAKEVGLLHNHSHDHSHQHSDGHCHDNDHDHSH 579
            ||: :..|.:........||::.... |.:.:|.:|                     ..|.:|..
Human   438 LDK-QLAEPQCSFEDLNNEKKSALQL-EQQVKELQE---------------------KLDEEHLE 479

  Fly   580 EHNHHN--------------AGDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAE 630
            ..:..|              .||.|               .|....:.:.|.
Human   480 AASQRNQQLETQLSLVALPGEGDGG---------------QHLDSEEEEAPR------------- 516

  Fly   631 TLPTAEAVERLQSR-----FTTLISQVADLTEEKHSLEHLVLQLQSETETIGEYIALYQTQRRML 690
              ||....|.|:||     |..|..:.||.||:....|...:|....|:.:.|...:|::|..:.
Human   517 --PTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVP 579

  Fly   691 KQREYEKAAQMRLLQAEREQLREKIEALNKLVVSL------------GVELPAD----AAQAKQP 739
            ..|..|....:||.|.| |:::.|:..|.:||:.|            ..:.|||    .|.|.|.
Human   580 NTRHQEMEDVIRLAQKE-EEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQE 643

  Fly   740 EAAAGSEHTPGEGENSQQIINKIQDIISEIK-ENTEQPS---------HNH 780
            ..|||.                 ||:..|:. :|..:|:         ||:
Human   644 LGAAGE-----------------QDVFYEVSLDNNVEPAPGVAREGSPHNN 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	77/304 (25%)
		GOLGA2L5	267..725	CDD:464485	110/480 (23%)
GOLGA6D	NP_001138696.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..70		27/68 (40%)
		SMC_prok_B	<68..284	CDD:274008	59/265 (22%)
		GOLGA2L5	217..628	CDD:464485	111/495 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..547		16/79 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..693		3/16 (19%)
		GM130_C	673..>693	CDD:465957	2/5 (40%)