Protein Alignment GM130 and GOLGA8T

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001342398.1
• Gene: GOLGA8T / 653075
• HGNCID: 44410
• Length: 631
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 163/708 - (23%)
• Similarity: 271/708 - (38%)
• Gaps: 209/708 - (29%)

  Fly     1 MPDDTQDAKAQKLAAARKKLKEYQQRAS-------NNNGQPGAEEPVAATTQSHSSTVSISSNLS 58
            |.::||.   .|||||:||||||.|:.|       |.|.:.....|..||
Human     1 MAEETQH---NKLAAAKKKLKEYWQKNSPRVPAGANRNRKTNGSIPEKAT--------------- 47

  Fly    59 ERSDSEINVNGGGAGGTQPPEQSALPTAASYFAQNESEHNGGLADASSLQAIQVIIAEKAQLNAE 123
                         :||.|||..||           ...|..|...:::|:.::....|:|
Human    48 -------------SGGCQPPRDSA-----------TGFHREGPTSSATLKDLESPCQERA----- 83

  Fly   124 LTKVRLACRERELELEEL----RILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQLQAQLLQSQ 184
                 :....|.:|:.:|    :.||.|.:....||::  :.:.:..:|:.::..::|.|.|..|
Human    84 -----VVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEE--EKKANNKKQKAKRVLEVQIQTLNIQ 141

  Fly   185 -AQIKDQQSHL-----------NELEAQLKQSNQHQEELQQQLSQKSNELEMAQLKLRQLSDESS 237
             .::.....|:           .:|..:|:.|.|.:.||:..|   ||.:...:.|..|||..|.
Human   142 KEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVL---SNVMATQKKKANQLSSRSK 203

  Fly   238 VTTDNRVESLVQTQYMYEQQIRDLQAMVGQLTQDKE---QAAGQYQNYVQHQSGEIAKLNERNTE 299
                      .:|::..||.:|:...:..||||.||   |...:...|.:|..||.|:..:|..:
Human   204 ----------ARTEWKLEQSMREETLLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQRMRK 258

  Fly   300 LSEVLNSLRERERQLVEHVGALERDIQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQ 364
            :|:.:.:|::.::|.:..|..|||.:.|   |:.|..|....:|....:      :.||..|:::
Human   259 MSQEICTLKKEKQQDMRRVEELERSLSK---LKNQMAEPLPPEPPAVPS------EVELQHLRKE 314

  Fly   365 IENFEFERHEFQLKIKSQDDQLQLKNSALDE-LEKQLERLQAEQ---PDQSKLLATMESDKVAAS 425
            :|..   ..|.|.::| ::.::.|.|...:| :::|.|||:.::   .:|.|.|
Human   315 LERV---AGELQAQVK-KNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL----------- 364

  Fly   426 RALTQNVEMKNQLDELQQRFVQLTNDKAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFK 490
                      .||.:.|..|.:..|                    :|.|:::.:.|..|.:.|..
Human   365 ----------QQLAKPQSVFEEPNN--------------------ENKNALQLEQQVKELQEKLG 399

  Fly   491 DEEMIRLSHENVELQRQQLMLQQQLDRLRHYEAKAYHAGEETEKENGADAPEN--------EAEE 547
            :|.:...|.:|     |||..|..|..|    ....|.||..:.| |.:||:.        |:.|
Human   400 EEHLEAASQQN-----QQLTAQLSLMAL----PGEGHGGEHLDSE-GEEAPQPMPSVPEDLESRE 454

  Fly   548 A-------------------KEVGLLHNHSHDHSHQHS------DGHCHDNDHDHSHEHNHHNA- 586
            |                   ||:..:| |..|..||.:      .|.|   ..|.:....||.|
Human   455 AMSSFMDHLKEKADLSELVKKELCFIH-HWRDRRHQKTHHLLSEPGGC---AKDAALGGGHHQAG 515

  Fly   587 ---GDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAETLPTAEAVERL 641
               ||.|.......|....:|:       :::.|......||..|.|..|.|.|.:.|
Human   516 AQGGDEGEAAGAAADGIAAYSN-------YNNGHRKFLAAAHNPADEPGPGAPAPQEL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	73/323 (23%)
		GOLGA2L5	267..725	CDD:464485	98/419 (23%)
GOLGA8T	NP_001342398.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		31/116 (27%)
		EnvC	86..>290	CDD:443969	54/221 (24%)
		GOLGA2L5	226..>510	CDD:464485	78/351 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..379		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..445		7/22 (32%)
		GM130_C	592..631	CDD:465957