Protein Alignment GM130 and GOLGA6L4

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_054234583.1
• Gene: GOLGA6L4 / 643707
• HGNCID: 27256
• Length: 609
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 134/630 - (21%)
• Similarity: 244/630 - (38%)
• Gaps: 180/630 - (28%)

  Fly     1 MPDDTQDAKAQKLAAARKKLKEYQQRAS-------NNNGQPGAEEPVAATTQSHSSTVSISSNLS 58
            |.:.||..   |||||:||||.|.||.|       |...:.....|..||:..:.|.
Human    13 MSEKTQQG---KLAAAKKKLKAYWQRKSPGIPAGANRKKKINGSSPDTATSGGYHSP-------- 66

  Fly    59 ERSDSEINVNGGGAGGTQPPEQ---------SALPTAASYFAQ-------------NESEHNGGL 101
              .||...:.|.|...:...|.         .||.::::..:|             .|.:|...|
Human    67 --GDSATGIYGEGRASSTTLEDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHL 129

  Fly   102 ------------------------ADASSLQAIQVIIAEKAQLNAELTKVRLACRERELELEE-- 140
                                    |..|.::.:|   .|...|..||..|.   |:.:.|:|.
Human   130 VQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQ---DETNHLRKELESVG---RQLQAEVENNQ 188

  Fly   141 -LRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQLQAQLLQSQAQIKDQQSHLNELEAQLKQS 204
             |.:|..:.:.||.:.::..::|:   |:||:|..:|..|    :.::::|:..|.|.|.:|.:.
Human   189 MLSLLNRRQEERLREQEERLREQE---ERQREQEDRLHEQ----EERLREQEERLCEQEERLCEQ 246

  Fly   205 NQHQEELQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRDLQAMVGQLT 269
            .:...|.:::|.::...|...:.:||:                 |.:.::||:.|        |.
Human   247 EERLREHEERLCEQEERLCEQEERLRE-----------------QEERLHEQEER--------LR 286

  Fly   270 QDKEQAAGQYQNYVQHQS---GEIAKLNERNTELSEVLNSLRERERQLVEHVGALERDIQKNISL 331
            :.:|:...|.:...:|:.   .:..:|.|:...|.|....|||:|.:|.|....| |:.::.:..
Human   287 EQEERLCEQEERLREHEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERL-REQEERLCE 350

  Fly   332 QAQ-------FKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQDDQLQLK 389
            |.:       .:|..::...:....||:.|.:...:|:|..:..|.||.:      .:.::|..:
Human   351 QEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEKLLEQERQQ------EEQERLLER 409

  Fly   390 NSALDELEKQLERLQAEQPDQSKLLATMESDKVAASRALTQNVEMKNQLDELQQRFVQLTNDKAE 454
            ...|:|:||.||: :..|.:|.:||                  |.:..|||::    :|.::..|
Human   410 ERLLEEVEKLLEQ-ERRQEEQERLL------------------ERERLLDEVE----ELLDEVEE 451

  Fly   455 LVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKD-EEMIRLSHENVELQRQQ---------- 508
            |   |:.|....::.|.......|:|:...|..:.:: |.|:.|..|.:..||.:
Human   452 L---LEQERLRQQDERLWQQETLQELERLRELERLRELERMLELGWEALYEQRAEPRSGFEELNN 513

  Fly   509 -----LMLQQQLDRLRHYEAKAYHAGEETEKENGADAPENEAEEA 548
                 |.|:||:              :|.:|..||:.|......|
Human   514 ENKSTLQLEQQV--------------KELKKSGGAEEPRGSESAA 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	68/313 (22%)
		GOLGA2L5	267..725	CDD:464485	66/308 (21%)
GOLGA6L4	XP_054234583.1	GOLGA2L5	83..>198	CDD:464485	20/120 (17%)