Protein Alignment GM130 and LAMA3

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_011524280.1
• Gene: LAMA3 / 3909
• HGNCID: 6483
• Length: 3342
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 174/904 - (19%)
• Similarity: 306/904 - (33%)
• Gaps: 233/904 - (25%)

  Fly    17 RKKLKEYQQRASNNNGQ-PGAEEPVAATTQSHSSTVSISSNLSERSDSEINVNGGGAGGTQPPEQ 80
            |.:|..|:...||:..: .|.|..:....|.. .|:...:.::.|....:|.|...|  ||..::
Human  1880 RNQLLNYRSAISNHGSKIEGLERELTDLNQEF-ETLQEKAQVNSRKAQTLNNNVNRA--TQSAKE 1941

  Fly    81 SALPTAASYFAQN-----------ESEHNGGLADASSLQAIQVIIAEKAQLNAELTKVRLACRER 134
              |........:|           :.|.|...:...|.:     .||..::..||.........|
Human  1942 --LDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSRE-----WAEAQRMMRELRNRNFGKHLR 1999

  Fly   135 ELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYA-QLQAQLLQSQAQIKDQQSHLNELE 198
            |.|.:     |.::||.|.::    :..|.|.:.:....| .::..|.:.:|::.|.::.|.|..
Human  2000 EAEAD-----KRESQLLLNRI----RTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAA 2055

  Fly   199 AQLKQSNQHQEE-------LQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQYMYEQ 256
            ||.||:|...:|       :|:|: ::.|.|:....|....:|.|.:.|:..::.:.::|..||:
Human  2056 AQAKQANGLNQENERALGAIQRQV-KEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEK 2119

  Fly   257 --------------QIRDLQAMVGQ--LTQDKEQAAGQYQNYVQHQSGEIAKLNERNTEL----- 300
                          ::|:|....|:  |.::.|:.|...|...: |..|| |.|....||
Human  2120 LAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAK-QLEEI-KRNASGDELVRCAV 2182

  Fly   301 ------SEVLNSLRERE----RQLVEHVGALERDIQKNISLQAQFKEASQVQPSKEETSEQKALK 355
                  ..:||:::..|    |.......||:..|::::..:|:...::..:...|....||.||
Human  2183 DAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLK 2247

  Fly   356 DELA--------------VLKEQIEN---------FEFERHEFQLKIKSQDDQLQLKNSALDELE 397
            .|::              |.||.|:.         ...:|.:....|.|....::..|...||:
Human  2248 QEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEV- 2311

  Fly   398 KQLERLQAEQPDQSKLLATMESDKVAASRALTQNVEMKNQLDELQQRFVQLTNDKAELVIRLDSE 462
              |:.|...|.|..::..|.         ..|||.:.|..|.:......:|||...:|..:::|
Human  2312 --LDGLNPIQTDVERIKDTY---------GRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIES- 2364

  Fly   463 EFANRE------IRQNYNSMEQKLQANEE---------RFKFKDEEMIRLSHENVELQRQQLMLQ 512
              .|::      |..|.:.:.:.:|...:         ||..|....:||.::
Human  2365 --INQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPND------------ 2415

  Fly   513 QQLDRLRHYEAKAYHAGEETEKENGADAPENEAEEAKEVGLLHNHSHDHSHQHSDGHCHDNDHDH 577
              |:.|:.|.:.:........:|||       ..|...|..|.|
Human  2416 --LEDLKGYTSLSLFLQRPNSRENG-------GTENMFVMYLGN--------------------- 2450

  Fly   578 SHEHNHHNAGDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAETLPTAEAVERLQ 642
                               .|.:.|:......|.|....::.|...|..|..:.|..:|..|.:.
Human  2451 -------------------KDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVM 2496

  Fly   643 SRFT-TLISQVADLTEEKHSL----------------EHLVLQLQSETET--IGEY--------- 679
            .|.. ..|.|.|.|...|.:.                .:.:|.|..|...  :|.|
Human  2497 DRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSR 2561

  Fly   680 ---------IALYQTQRRMLKQREYEKAAQMRLLQAEREQLREKIEALNKLVVSLGVELPADAAQ 735
                     |.|......:|....::|...:...:.|..: |.|.|:........|.........
Human  2562 LSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCR-RRKEESDKNYFEGTGYARVPTQPH 2625

  Fly   736 AKQPEAAAGSEHTPGEG-----ENSQQIIN-KIQD--IISEIKENTEQPSHNHAGDHLN 786
            |..|......:.|...|     ||..:.|: .|:|  ::...|.|:|.|.....||.:|
Human  2626 APIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAIN 2684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	78/362 (22%)
		GOLGA2L5	267..725	CDD:464485	98/549 (18%)
LAMA3	XP_011524280.1	LamNT	46..297	CDD:214532
		EGF_Lam	299..344	CDD:238012
		Laminin_EGF	356..423	CDD:395007
		EGF_Lam	425..465	CDD:238012
		Laminin_EGF	491..538	CDD:395007
		EGF_Lam	535..577	CDD:238012
		Laminin_EGF	585..628	CDD:395007
		EGF_Lam	631..682	CDD:238012
		EGF_Lam	684..727	CDD:238012
		Laminin_EGF	1275..1323	CDD:395007
		Laminin_EGF	1365..1416	CDD:395007
		EGF_Lam	1413..1463	CDD:238012
		Laminin_B	1527..1661	CDD:459652
		EGF_Lam	1695..1741	CDD:238012
		Laminin_EGF	1743..1793	CDD:395007
		Laminin_I	1856..2113	CDD:310534	53/252 (21%)
		HEC1	<2066..2384	CDD:444066	68/335 (20%)
		Laminin_II	2297..2425	CDD:368703	30/156 (19%)
		LamG	2444..2579	CDD:214598	26/174 (15%)
		LamG	2611..2751	CDD:238058	17/74 (23%)
		LamG	2778..2910	CDD:238058
		LamG	3003..3143	CDD:238058
		LamG	3167..3318	CDD:238058