Protein Alignment GM130 and GOLGA6A

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001033729.2
• Gene: GOLGA6A / 342096
• HGNCID: 13567
• Length: 693
• Species: Homo sapiens
• Alignment Length: 835
• Identity: 192/835 - (22%)
• Similarity: 328/835 - (39%)
• Gaps: 223/835 - (26%)

  Fly     6 QDAKAQKLAAARKKLKEYQQRASNNNGQPGAEEPVAATTQSHSSTVSISSNLSERSDS--EINVN 68
            ::::..|||||:|||||||||.|     ||.  |..|.|:            .:::||  |...:
Human    15 EESRQNKLAAAKKKLKEYQQRKS-----PGI--PAGAKTK------------KKKTDSSPETTTS 60

  Fly    69 GG--GAGGTQPPEQSALPTAASYFAQNESEHNGGLADASSLQAIQVIIAEKAQLNAELTKVRLAC 131
            ||  ..|.:|..|.                       |.:|::..|.|   :|||..:..::...
Human    61 GGCHSPGDSQYQEL-----------------------AVALESSSVTI---SQLNENIESLKQQK 99

  Fly   132 RERELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQLQAQLLQSQAQIKDQQSHLNE 196
            ::.|.:|||.:  |..|::...|:     ::..|......:.|.|:..|..::...:..:....:
Human   100 KQVEHQLEEAK--KTNNEIHKAQM-----ERLETINILTLEKADLKTTLYHTKRAARHFEEESKD 157

  Fly   197 LEAQLKQSNQHQEELQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRD- 260
            |..:|:.|.|..:||::.|...|.:        :|..|.||...:..::..:|      |.|::
Human   158 LAGRLQYSLQRIQELERALCAVSTQ--------QQEEDRSSSCREAVLQRWLQ------QTIKER 208

  Fly   261 --LQAMVGQLTQDKEQAAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEHVGALER 323
              |.|.|.|:|:..:|...:...|.:|..||.|:..||..::|....:|:|.:::.:..:..|||
Human   209 ALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELER 273

  Fly   324 DIQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQDDQLQL 388
            .:.:   |:.|..|...:.| ...||..:.|:||...|::::|..|.       |::||.:
Human   274 SLSE---LKNQMAEPPSLAP-PAVTSVVEQLQDEAKHLRQEVEGLEG-------KLQSQVE---- 323

  Fly   389 KNSALDELEK-QLERLQAEQPDQSKLLATMESDKV-AASRALTQNVEMKNQLDELQQRFVQLTND 451
            .|.||..|.| |.:|||    :|.::|...|:.:| ...|...||..::.|...||::..:|...
Human   324 NNQALSLLSKEQKQRLQ----EQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384

  Fly   452 KAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHENVELQRQQLMLQQ--Q 514
            :..|           |:..:.....|::||..|:|. :..||.:....|.::.|.::|.|.|  :
Human   385 EQRL-----------RKQEERLRKEEERLQKQEKRL-WDQEERLWKKEERLQKQEERLALSQNHK 437

  Fly   515 LDRLRHYEAKAYHAGEETEKENGADAPENEAEEAKEVGLLHNHSHDHSHQHSDGHCHDNDHDHSH 579
            ||: :..|.:........||::.... |.:.:|.:|                     ..|.:|..
Human   438 LDK-QLAEPQCSFEDLNNEKKSALQL-EQQVKELQE---------------------KLDEEHLE 479

  Fly   580 EHNHHN--------------AGDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAE 630
            ..:|.|              .||.|               .|....:.:.|.
Human   480 AASHQNQQLETQLSLVALPGEGDGG---------------QHLDSEEEEAPR------------- 516

  Fly   631 TLPTAEAVERLQSR-----FTTLISQVADLTEEKHSLEHLVLQLQSETETIGEYIALYQTQRRML 690
              ||....|.|:||     |..|..:.||.||:....|...:|....|:.:.|...:|::|..:.
Human   517 --PTPNIPEDLESREATSSFMDLPKEKADGTEQVERRELGFVQPSGVTDGMRESFTVYESQGAVP 579

  Fly   691 KQREYEKAAQMRLLQAEREQLREKIEALNKLVVSL------------GVELPAD----AAQAKQP 739
            ..|..|....:||.|.| |:::.|:..|.:||:.|            ..:.|||    .|.|.|.
Human   580 NTRHQEMEDVIRLAQKE-EEMKVKLLELQELVLPLVGNHEGHGKFLIAAQNPADEPTPGAPAPQE 643

  Fly   740 EAAAGS---------------------EHTPGEGENSQQIINKIQDIISEIKENT 773
            ..|||.                     |.:|.:....|||:.     :|.:.::|
Human   644 LGAAGEQDVFYEVSLDNNVEPAPGAAREGSPHDNPTVQQIVQ-----LSPVMQDT 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	74/304 (24%)
		GOLGA2L5	267..725	CDD:464485	111/480 (23%)
GOLGA6A	NP_001033729.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..69		26/67 (39%)
		SMC_prok_B	<68..284	CDD:274008	56/265 (21%)
		GOLGA2L5	217..628	CDD:464485	112/495 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..547		16/79 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..693		6/36 (17%)
		GM130_C	673..>693	CDD:465957	5/24 (21%)