Protein Alignment GM130 and Fkbp15

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_006538097.1
• Gene: Fkbp15 / 338355
• MGIID: 2444782
• Length: 1255
• Species: Mus musculus
• Alignment Length: 645
• Identity: 124/645 - (19%)
• Similarity: 252/645 - (39%)
• Gaps: 154/645 - (23%)

  Fly     4 DTQDAKAQK--------------LAAARKKLKEYQQRASNNNGQPGAEEPVAATTQSHSSTVSIS 54
            :|:||...:              |..|...|.:...:|...:|. |.:.|.||..|:    ||:.
Mouse   387 ETEDATVLRGAGQSLVTPSIQPSLQPAHPVLPQMASQAPQPSGS-GLQTPSAALMQA----VSLD 446

  Fly    55 SNLSERSDSEINVNGGGAGGTQP---PEQSALPTAASYFAQ------------NESEHNGGLADA 104
            |:         :...|.|...||   .:..|.|...|..:|            :::.|..|..|.
Mouse   447 SH---------SAVSGNAQNFQPYAGVQAYAYPQTPSVTSQLQPVRPLYPAPLSQAPHFQGSGDM 502

  Fly   105 SSLQAIQVIIAEKAQLNAELTKVRLACRERELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQ- 168
            .|.     ::.|..|.|   |::|:|..:...:::.|       ..::|:||:|     |:|..
Mouse   503 MSF-----LMTEARQHN---TEIRMAVNKVADKMDHL-------MTKVEELQKH-----SSGNSM 547

  Fly   169 ------------------QR--QQYAQLQAQLLQSQAQIKDQQSHLNELEAQLKQSNQHQEELQQ 213
                              ||  |:..:|:.:||:..::|::|...:::|   ::::.::.|:...
Mouse   548 LLPSMSVTMETSMIMSNIQRIIQENERLKQELLEKSSRIEEQNDKISDL---IERNQRYVEQSNL 609

  Fly   214 QLSQKSNELEMA----QLKLRQLSDESSVTTDNRVESLVQTQYM------YEQQIRDLQAMVGQL 268
            .:.:::|.|:.|    |.::.....|.:..|:....:..|..::      ::::..:||.   ||
Mouse   610 MMEKRNNSLQTATENTQARILHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQL---QL 671

  Fly   269 TQDKEQAAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEHVGALERD--------- 324
            | |..:.....:.:|.....::::|.|.:.:......|.::..|||...|.:||.:
Mouse   672 T-DNLKETDLLRGHVTRLQADLSELREASEQTQTKFKSEKQSRRQLELKVTSLEEELTDLRAEKT 735

  Fly   325 -IQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQI------------ENFEFERHEFQ 376
             ::||:|.:.:.....:.|...|....:|:.::||..|::.:            |.....:.|.|
Mouse   736 SLEKNLSERKKKSAQERCQAEAEMDEIRKSHQEELDRLRQLLKKARVSTDQAAAEQLTLAQAELQ 800

  Fly   377 LKIKSQDDQLQLKNSALDELEKQLERLQAEQPDQSKLLATMESDKVAASRALTQNVEMKNQLDEL 441
            .:.:::.:||..  ||.||..:|...:.|::....:.||.::.:.:|....:....|.|..:..|
Mouse   801 SQWEAKCEQLLA--SARDEHLQQYREVCAQRDAHQQKLALLQDECLALQAQIAAFTEQKEHMQRL 863

  Fly   442 QQRFVQLTNDKAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHENVELQR 506
            ::...|....:|    ..|..|...:.:.|.:.|:..:.:..|   .:....::|.....:::..
Mouse   864 EKTKSQAPAGRA----AADPSEKVKKIMNQVFQSLRGEFELEE---SYDGGTILRTIMHTIKMVT 921

  Fly   507 QQLMLQQQLDRLRHYEAKAYHAGEETEK-------ENGADA--------PENEAEEAKEV 551
            .||:..|:       |.:.....||.||       |....|        |..|.:||.||
Mouse   922 LQLLNHQE-------EEEEEEEEEEEEKKPLRPSLEQPGPATPGMPPAPPSGETQEAPEV 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	66/353 (19%)
		GOLGA2L5	267..725	CDD:464485	64/322 (20%)
Fkbp15	XP_006538097.1	FKBP_C	192..285	CDD:459735
		Atrophin-1	302..>497	CDD:460830	25/123 (20%)
		Smc	<561..>885	CDD:440809	63/336 (19%)
		PHA03247	<944..1129	CDD:223021	8/31 (26%)