Protein Alignment GM130 and golg-2

DIOPT Version :10

• Sequence 1: NP_611642.2
• Gene: GM130 / 37524
• FlyBaseID: FBgn0034697
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_494929.3
• Gene: golg-2 / 173870
• WormBaseID: WBGene00018017
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 1001
• Identity: 224/1001 - (22%)
• Similarity: 394/1001 - (39%)
• Gaps: 283/1001 - (28%)

  Fly     1 MPDDTQDAKAQKLAAARKKLKEYQ--QRASNNN--------GQPGAEEPVAATTQSHSSTVSISS 55
            |.|....|||:.|||||||||:::  ||....|        .:|||    .|.....||.||..|
 Worm     1 MVDAAAPAKAEMLAAARKKLKDFEARQRLDGRNSPASSIISSEPGA----GAGLNGRSSVVSEDS 61

  Fly    56 NL-----SERSDSEINV-NGGGAGGTQP------PEQSALPT----AASYFAQNESEH-----NG 99
            ..     |..|...:|. ||..|...||      ...:.|.|    ..::::|..|.:     ||
 Worm    62 TALQIPHSSSSAQSLNARNGLDASPFQPNGNEWYQAYTQLKTQHDELCAHYSQLHSAYSQVNANG 126

  Fly   100 GLADASS----LQ-AIQVIIAEKA-------QLNAELTKVR--LACRER-----------ELELE 139
            ...|..:    || |:..::.||.       |.|.::.|:|  ||..|.           .|...
 Worm   127 IHVDTENQIVQLQNALSAMVEEKVSSQSDLRQANKQIEKLRHKLAAAENIANQMSNSTSSGLSSN 191

  Fly   140 ELRILKDQNQLRLEQLQQHCQDQQSTGEQQ-----RQQYAQLQAQLL-------QSQAQIKD--- 189
            |:|.|.       |.:.|  :|...|...|     |::.|.:||.||       ::||::|.
 Worm   192 EIRKLN-------EAIAQ--KDSLLTARHQELEGARREVASMQANLLNVQHERSEAQARVKSMIK 247

  Fly   190 ----QQSHLNEL-------EAQLKQ------------SNQHQEELQQQL----SQKSNEL-EMAQ 226
                |::.:::|       :..|||            .|.:.|.||::|    ::||..| |.|.
 Worm   248 ETAAQENRISQLMKDIQMKDLYLKQLGATGPPGGIPNENTNYENLQRELENVKAEKSRLLVESAT 312

  Fly   227 LKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRDLQAMVGQLTQDKEQAAGQYQNYVQHQSGEIA 291
            || ...:|........:.|..::.::::.|:..         :.|:.:   ..:|.::....|:.
 Worm   313 LK-AHYADREYALQQKQAEMALEIEHLHNQKFS---------SNDQVE---HLENQLEIAQSELQ 364

  Fly   292 KLNERNTELSEVLNSLRERERQLVEHVGALERDIQKNISLQAQFKEASQVQPSK-EETSEQKALK 355
            || :.|.::||     |..|...:     .|.|:.:.|      :||..|:..| |..||....:
 Worm   365 KL-QMNMDVSE-----RHDEIPTI-----TEEDVARRI------REACFVERGKWERRSEDDQKR 412

  Fly   356 DELAVLKEQIENFEFERHEFQLKIKSQDDQLQLKNSALDELEKQLERLQAEQPDQSKLLATMESD 420
            .|..:|::....||.|:...:|::|.:            .||::.....|...|...|...::::
 Worm   413 REEEILEKDKVIFEREQSLAELEMKYR------------LLEERTLESTANGADLLSLSEQLQNE 465

  Fly   421 KVAASRALTQNVEMKNQLDELQQRFVQLTNDKAELVIRLDSEEFANREI---------------- 469
            |...|||:.||.|:|.:|.|.:.|||.||.:||::.:...|.|...||:
 Worm   466 KATVSRAVAQNKELKERLLETEDRFVTLTKEKADVELAKQSAEHQVRELTKQLNLETAGLVGNLS 530

  Fly   470 ----RQNYNSMEQKLQANEERFKFKDEEMIRLSHENVE----LQRQQLMLQQQLDRLRHYEAKAY 526
                ||.:....|:..|::|: :.:.:|:::|:.|..|    |||:...::..|: |:.:|.:..
 Worm   531 EVIARQPHLEASQESAASQEQ-REESQEIVKLNEELKENISTLQRENAEIRSDLE-LKTHELQLV 593

  Fly   527 HAG-----------EETEKENGADAPEN--EAEEAKEVGLLHN-HSHDHSHQHSDGHCHDNDHDH 577
            .|.           :|..::|..|..:|  ..|..:.||.:.: |:.:.:.:.:..:|.....|
 Worm   594 RADLRRSNTHNEQMDEIMRQNAEDENQNSIHVELTQAVGRVQDLHAENEALREAFNNCRQQLED- 657

  Fly   578 SHEHNHHNAGDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAETLPTAEAVERLQ 642
              |.....|.:.....:...:.........|.:.::        ..:.|:..|.|   .|.:.|:
 Worm   658 --ERADRRAEEERKDLESKQEQLELKETKVPEEAEN--------QQSSRELHEDL---WARKELE 709

  Fly   643 SRFTTLISQVADLTEEKHSLEHLVLQLQSETETIGEYIALYQTQRRMLKQREYEKAAQMRLLQAE 707
            .||...:.|.|:|.|....|||:..||:.|.:||.:::.|||.||:::::|...|..|::.::.:
 Worm   710 KRFARAMLQNAELVETIDRLEHINQQLELENDTIADHVVLYQHQRKLVRERLRVKDEQLKAMEED 774

  Fly   708 REQLREKIEALNKLVVSL----GV---------------------------------ELPADAAQ 735
            |.:...:.:.|..:::::    ||                                 ::..||..
 Worm   775 RTKTVARCQELQNVLMTVLNKGGVLKEYQTSSISRKAARRVSRSYSHSTVDEMSGDEDVLVDAKL 839

  Fly   736 AKQPE-----AAAGSEHTPG-------EGENSQQI--------------------INKIQDIISE 768
            .:.||     ..:..|..|.       |.:||.::                    :.:|.:|||:
 Worm   840 EEVPEREKVHGNSDDEKIPSTPPPTVLEAQNSPRLSDCSADKDNSDTFGQTQDASVRRILEIISD 904

  Fly   769 IKENTEQPSHNHAGD-HLNCCMGKFE 793
            |    .:|....||. |...|:|..:
 Worm   905 I----SRPQILPAGQLHCTQCIGDLQ 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GM130	NP_611642.2	Smc	<110..>411	CDD:440809	78/364 (21%)
		GOLGA2L5	267..725	CDD:464485	111/496 (22%)
golg-2	NP_494929.3	Smc	<132..>679	CDD:440809	131/602 (22%)
		GOLGA2L5	<435..790	CDD:464485	85/382 (22%)