Protein Alignment Vrp1 and Wipf2

DIOPT Version :9

• Sequence 1: NP_001097406.1
• Gene: Vrp1 / 37521
• FlyBaseID: FBgn0243516
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_922922.1
• Gene: Wipf2 / 68524
• MGIID: 1924462
• Length: 440
• Species: Mus musculus
• Alignment Length: 761
• Identity: 179/761 - (23%)
• Similarity: 230/761 - (30%)
• Gaps: 338/761 - (44%)

  Fly     1 MAIPPPPGPPPPPGPPPPPAMGGL-----KLGGAGGADARSALLSSIQKGTKLKKTTTV-DKSGP 59
            |.||||  |||||||||||.....     ||......: |.|||..|.|||||||.|.| |:|.|
Mouse     1 MPIPPP--PPPPPGPPPPPTFNQANTEQPKLSRDEQRN-RGALLQDICKGTKLKKVTNVNDRSAP 62

  Fly    60 ALSGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNG 124
            .:. |..|..||.|.||...                       .|| ||||:|  .:|||:||..
Mouse    63 VIE-KPRGSSGGYGPGAAAL-----------------------QPK-GGLFQG--GVPKLRPVGA 100

  Fly   125 IRATPS-AGSAATTTSKSTTNSSAQQRSNSP-PAATSASNASNGPMDFNTELTKHLTLKRQKQQQ 187
            ..|:.: ||..|.....|        |:.:| |..::||...:...|.|......|       .:
Mouse   101 KDASEAPAGKPALQVPSS--------RAAAPRPPGSAASGRPHDDTDSNRASLPEL-------PR 150

  Fly   188 QQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAAS 252
            .|:|..|..:....|:...::.:...||.||..        .|.|.|.| |.|...|
Mouse   151 MQRPSLPDLSRPNTASGTGMKHSSSAPPPPPPG--------RRANAPPT-PLPLHSN-------- 198

  Fly   253 PTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGSVRNLA 317
                                |::|.|..                                 :.|.
Mouse   199 --------------------KAQAYNRE---------------------------------KPLP 210

  Fly   318 PNK-STLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPAISFGKPNFA 381
            |.. ..|..|..|              |.:.||        |.|.|.|:.:...|:   |: :.|
Mouse   211 PTPGQRLHPGREG--------------HPAPPP--------VKPPPSPVNIRTGPS---GQ-SLA 249

  Fly   382 PKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSS 446
            |.||..                       |.||  |:.||...||.:             |....
Mouse   250 PPPPPY-----------------------RQPP--GVPNGPSSPTNE-------------SAPEL 276

  Fly   447 PNTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAP 511
            |.......|..|.|.:.    ..|||||.|                          :.::.|..|
Mouse   277 PQRHNSLHRKTPGPVRG----LAPPPPTSA--------------------------TPSLLSNRP 311

  Fly   512 SPPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVK 576
            .||..:|||               ||.|        ||.||
Mouse   312 PPPAREPPS---------------RGAA--------PPPPP------------------------ 329

  Fly   577 PIILNGGPLNPPAPPPHRSCPPPPPPQRQSSNQDRVKYWIDKTVYSFKKILHINRQGRHSGESVK 641
            |:|.||.          |..||||||.|.                             |..|.
Mouse   330 PMIRNGA----------RDAPPPPPPYRM-----------------------------HGSEP-- 353

  Fly   642 VINMLNSKRNGGSGSGSAPVPPQRHSSIRPNAPSTPPTHMANASHQFGSSSGLSSGSGAGAAASV 706
                        ...|..|.||.|    .|..|..||.......|:             .:..:|
Mouse   354 ------------PSRGKPPPPPSR----TPAGPPPPPPPPLRNGHR-------------DSITTV 389

  Fly   707 GRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKAT-NAP 751
            ...::|.|:|:.  ||.|.:||.|..:.::|:||||:|.:|. .||
Mouse   390 RSFLDDFESKYS--FHPVEDFPAPEEYKHLQRVYPSKTNRAARGAP 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vrp1	NP_001097406.1	None
Wipf2	NP_922922.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		18/39 (46%)
		WH2	36..60	CDD:280384	15/24 (63%)
		Binds actin. /evidence=ECO:0000255	49..52		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..386		129/652 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..440		8/15 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8824
eggNOG	1	0.900	-	-		E1_KOG4462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.860