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Protein Alignment Vrp1 and WIPF3

DIOPT Version :9

Sequence 1:	NP_001097406.1	Gene:	Vrp1 / 37521	FlyBaseID:	FBgn0243516	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001073998.2	Gene:	WIPF3 / 644150	HGNCID:	22004	Length:	483	Species:	Homo sapiens

Alignment Length:	811	Identity:	175/811 - (21%)
Similarity:	239/811 - (29%)	Gaps:	382/811 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPPPGPPPPP----GPPPPPA-------MGGLKLGGAGGADARSALLSSIQKGTKLKKTTTV-DK 56
            ||||.|||||    .|||||:       ...|:.....|   |||||:.||:||:|:|.|.: |:
Human     7 PPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKG---RSALLADIQQGTRLRKVTQINDR 68

  Fly    57 SGPAL-SGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGT-PKLGGLFEGLSQMPKL 119
            |.|.: |.|....:||                      .|:|..|..| |.||.||.|  ..|.|
Human    69 SAPQIESSKGTNKEGG----------------------GSANTRGASTPPTLGDLFAG--GFPVL 109

  Fly   120 KPVNGIRATPSAGSAATTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKRQK 184
            :|                         |.||.      .:......||
Human   110 RP-------------------------AGQRD------VAGGKTGQGP----------------- 126

  Fly   185 QQQQQQPQPPTNNTHINATEANLRTNRGP--PPQPPKSANSNDSILERMNIPRTAPTPPFGNSSS 247
              ..:.|.|...|          :|..||  ||..|:..|::    |.....||||..|
Human   127 --GSRAPSPRLPN----------KTISGPLIPPASPRLGNTS----EAHGAARTAPPRP------ 169

  Fly   248 VKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGS 312
                                            |:.
Human   170 --------------------------------NVP------------------------------ 172

  Fly   313 VRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPAISFGK 377
                ||                             ||          |||||...|:.|.:
Human   173 ----AP-----------------------------PP----------PTPPPPPPPLPPPL---- 190

  Fly   378 PNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPR-SPPAAGIVNGLVFPTQQHLGTLRGPLQFHG 441
            |:.:|                        :|:|. |||                    |||
Human   191 PSSSP------------------------IKTPLVSPP--------------------GPL---- 207

  Fly   442 SESSSPNTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAI 506
            ::.:.| ..|..:.|||.||      .|||||||                      ..|..:|.:
Human   208 TKGNLP-VVAPPVPCAPPPP------PPPPPPTP----------------------PPLPPASVL 243

  Fly   507 SSQAPSP-------PITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSAS 564
            |.:|..|       |...||...........|:.:   .|..:..|..||.||.|.    |..||
Human   244 SDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAE---PASPAQDAQEPPAPPPPL----PPYAS 301

  Fly   565 ASPKSLLRDNVKPIILNGGPLNPPAPP--PHRSCPP--------PPPPQRQSSNQDRVKYWIDKT 619
            .||::.|.....|.:.:.....||.||  |....||        |.||....|..
Human   302 CSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQP---------- 356

  Fly   620 VYSFKKILHINRQGRHSGESVKVINMLNSKRNGGSGSGSA-----PVPPQRHSSIRPNAPSTPPT 679
                                     .|..||:|..|:|..     |.||.|          :|.|
Human   357 -------------------------FLQKKRHGRPGAGGGKLNPPPAPPAR----------SPTT 386

  Fly   680 HMANASHQFGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRT 744
            .:::.|.|..:.:......|.....|: .:::|.|:||  .||:|.:||.|..:...||:|||:
Human   387 ELSSKSQQATAWTPTQQPGGQLRNGSL-HIIDDFESKF--TFHSVEDFPPPDEYKPCQKIYPSK- 447

  Fly   745 FKATNAPG----NSSVNNNNNAVASNNNTTS 771
            ...:..||    ..:|..:::.:...|:..|
Human   448 IPRSRTPGPWLQAEAVGQSSDDIKGRNSQLS 478

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.