Protein Alignment Vrp1 and WIPF2

DIOPT Version :10

• Sequence 1: NP_001097406.1
• Gene: Vrp1 / 37521
• FlyBaseID: FBgn0243516
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_573571.1
• Gene: WIPF2 / 147179
• HGNCID: 30923
• Length: 440
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 176/760 - (23%)
• Similarity: 227/760 - (29%)
• Gaps: 336/760 - (44%)

  Fly     1 MAIPPPPGPPPPPGPPPPPAMGGL-----KLGGAGGADARSALLSSIQKGTKLKKTTTV-DKSGP 59
            |.||||  |||||||||||.....     || .......|.|||..|.|||||||.|.: |:|.|
Human     1 MPIPPP--PPPPPGPPPPPTFHQANTEQPKL-SRDEQRGRGALLQDICKGTKLKKVTNINDRSAP 62

  Fly    60 ALSGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNG 124
            .|. |..|..||.|.|                        |......||||:|  .:.||:||
Human    63 ILE-KPKGSSGGYGSG------------------------GAALQPKGGLFQG--GVLKLRPV-- 98

  Fly   125 IRATPSAGSAATTTSKSTTNSSAQQRSNSPPAA--TSASNASNGPMDFNTELTKHLTLKRQKQQQ 187
                     .|...|::.....|.|..:|..||  ...|.||..|.| :|:.::....:..:.|:
Human    99 ---------GAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQD-DTDSSRASLPELPRMQR 153

  Fly   188 QQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAAS 252
            ...|.....||  .::.....::..|||.||.         .|.|.|.| |.|
Human   154 PSLPDLSRPNT--TSSTGMKHSSSAPPPPPPG---------RRANAPPT-PLP------------ 194

  Fly   253 PTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGSVRNLA 317
                                               ::|||    |...:....|..:.|  :.|.
Human   195 -----------------------------------MHSSK----APAYNREKPLPPTPG--QRLH 218

  Fly   318 PNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPAISFGKPNFAP 382
            |.                         :..||    :.|.|.|.|.|:.:...|:   |: :.||
Human   219 PG-------------------------REGPP----APPPVKPPPSPVNIRTGPS---GQ-SLAP 250

  Fly   383 KPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSSP 447
            .||..                       |.||  |:.||...||.:             |....|
Human   251 PPPPY-----------------------RQPP--GVPNGPSSPTNE-------------SAPELP 277

  Fly   448 NTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAPS 512
            .......|..|.|.:.    ..|||||.|                          |.::.|..|.
Human   278 QRHNSLHRKTPGPVRG----LAPPPPTSA--------------------------SPSLLSNRPP 312

  Fly   513 PPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVKP 577
            ||...|||               ||.|        ||.||                        |
Human   313 PPARDPPS---------------RGAA--------PPPPP------------------------P 330

  Fly   578 IILNGGPLNPPAPPPHRSCPPPPPPQRQSSNQDRVKYWIDKTVYSFKKILHINRQGRHSGESVKV 642
            :|.||.          |..||||||.|.                             |..|.
Human   331 VIRNGA----------RDAPPPPPPYRM-----------------------------HGSEP--- 353

  Fly   643 INMLNSKRNGGSGSGSAPVPPQRHSSIRPNAPSTPPTHMANASHQFGSSSGLSSGSGAGAAASVG 707
                       ...|..|.||.|    .|..|..||.......|:             .:..:|.
Human   354 -----------PSRGKPPPPPSR----TPAGPPPPPPPPLRNGHR-------------DSITTVR 390

  Fly   708 RLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKAT-NAP 751
            ..::|.|:|:.  ||.|.:||.|..:.:.|::|||:|.:|. .||
Human   391 SFLDDFESKYS--FHPVEDFPAPEEYKHFQRIYPSKTNRAARGAP 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vrp1	NP_001097406.1	None
WIPF2	NP_573571.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		18/37 (49%)
		WH2_WAS_WASL-2_3	33..62	CDD:409220	15/28 (54%)
		Binds actin. /evidence=ECO:0000255	49..52		2/2 (100%)
		actin-binding sequence	50..53	CDD:409220	2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..387		127/652 (19%)
		PHA03247	<96..308	CDD:223021	71/389 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..440		7/15 (47%)