Protein Alignment Vrp1 and Wipf1

DIOPT Version :10

• Sequence 1: NP_001097406.1
• Gene: Vrp1 / 37521
• FlyBaseID: FBgn0243516
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_476540.2
• Gene: Wipf1 / 117538
• RGDID: 620887
• Length: 487
• Species: Rattus norvegicus
• Alignment Length: 782
• Identity: 189/782 - (24%)
• Similarity: 249/782 - (31%)
• Gaps: 337/782 - (43%)

  Fly     1 MAIPPPPGPPPPP----GPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSGPAL 61
            |.:||||.|||||    .....|::...:..|      |:||||.|.||.|||||.|.|:|.|.|
  Rat     1 MPVPPPPAPPPPPTFALANTEKPSLNKTEQAG------RNALLSDISKGKKLKKTVTNDRSAPIL 59

  Fly    62 ------SGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLK 120
                  .|...||.||.|.|              .:|....|..|.|.|.|||||:  :.||||
  Rat    60 DKPKGAGGGYGGGSGGGGGG--------------GSSGGGGNFGGGGPPGLGGLFQ--AGMPKL- 107

  Fly   121 PVNGIRATPSAGSAATTTSKSTTNSSAQQRSNSPP------AATSASNAS--NGPMDFNTELTKH 177
                               :||.|.......:.||      .||||...|  :||..|......|
  Rat   108 -------------------RSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGH 153

  Fly   178 LTLKRQKQQQQQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPF 242
                     :...|:||              .||.|||:|...:.           |.:.| ||.
  Rat   154 ---------RSGPPEPP--------------RNRMPPPRPDVGSK-----------PDSLP-PPV 183

  Fly   243 GNSSSVKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLT 307
            .|       :|....|..::.||..|.|:.:..
  Rat   184 PN-------TPRPIPSSLHNRGSPAGLGAPRPP-------------------------------- 209

  Fly   308 SSTGSVRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLPMKPA 372
                    ...|:...||..|...:.|||         |||          .|.||   ||..|:
  Rat   210 --------FPGNRGAAFGAGSVRQNLSSS---------SSP----------FPRPP---LPPTPS 244

  Fly   373 ISF-GKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGP 436
            .:. .||   |.||             |.|....||.....||.         |:|..    :.|
  Rat   245 RALDDKP---PPPP-------------PPVGNRPSMHREAVPPP---------PSQNS----KPP 280

  Fly   437 LQFHGSESSSPNTSAGSMRCAPNPPKSRPSVKPPP-PPTPARSFSNTNLNNIGGSTMFSAVNTAL 500
            :      .|:|...||| :..|.||.|||.  ||| |||.:.........|
  Rat   281 V------PSTPRPGAGS-QAPPPPPPSRPG--PPPLPPTSSDEIPRLPQRN-------------- 322

  Fly   501 IQSSAISSQAPSPPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASA 565
                 :|..:|:||:..|                  |.:|        ||||.|..
  Rat   323 -----LSLTSPTPPLPSP------------------GRSG--------PLPPPPTE--------- 347

  Fly   566 SPKSLLRDNVKPIILNGGPLNPPAP---PPHRSCP-PPPPPQRQSSNQDRVKYWIDKTVYSFKKI 626
                                .||.|   ||.||.| |||||
  Rat   348 --------------------RPPPPVRDPPGRSGPLPPPPP------------------------ 368

  Fly   627 LHINRQGRHSGESVKVINMLNSKRNGGSGSGSAPVPPQRHSSIRPNAPST----PPTHMANASHQ 687
              |||.| .:..::.....|.| |:|.....|.|.||     :.|:.|..    ||....:..:.
  Rat   369 --INRNG-STARALPATPQLPS-RSGMDSPRSGPRPP-----LPPDRPGAGAPPPPPPSTSVRNG 424

  Fly   688 FGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKATNAPG 752
            |..||                ..::.|::|  .||.:::.|.|.|::...|.|||:..::.:..|
  Rat   425 FQDSS----------------CEDEWESRF--YFHPISDLPPPEPYVPTTKTYPSKVARSESRSG 471

  Fly   753 NS 754
            ::
  Rat   472 SN 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vrp1	NP_001097406.1	None
Wipf1	NP_476540.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..487		189/782 (24%)
		WH2_WAS_WASL-1	29..60	CDD:409219	18/36 (50%)
		Binds actin. /evidence=ECO:0000250	45..48		2/2 (100%)
		actin-binding sequence	46..49	CDD:409219	2/2 (100%)