Protein Alignment Vrp1 and wipf1b

DIOPT Version :10

• Sequence 1: NP_001097406.1
• Gene: Vrp1 / 37521
• FlyBaseID: FBgn0243516
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: XP_005165860.1
• Gene: wipf1b / 100151491
• ZFINID: ZDB-GENE-110815-1
• Length: 485
• Species: Danio rerio
• Alignment Length: 777
• Identity: 179/777 - (23%)
• Similarity: 227/777 - (29%)
• Gaps: 350/777 - (45%)

  Fly     1 MAIPPPPGPPPPP----GPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSGPAL 61
            |.|||||.|||||    .....|.:...:..|      |:||||.|.||.:|||..|.|:|.|.|
Zfish     1 MPIPPPPPPPPPPTFSQANTEKPVLNRSEQQG------RNALLSDISKGARLKKAVTNDRSAPVL 59

  Fly    62 ---------SGKVCGGDGGAGIGAKRTLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMP 117
                     .|...||.||.|.|                  ....|.|.|...|||||:|  .||
Zfish    60 DKPKGGGGPGGGGGGGGGGGGFG------------------GGGGGGGGGGGGLGGLFQG--GMP 104

  Fly   118 KLKPVNGIRATPSAGSAATTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKR 182
            ||                    :||.:.|...|   ||.....:. :.||..|.....   :..|
Zfish   105 KL--------------------RSTRDDSVSVR---PPVLPPVAR-TTGPRPFGGGSG---SAPR 142

  Fly   183 QKQQQQQQPQPPTNNTHINATEANLRTNRGPPPQPPKSANSNDSILERMNIPRTAPTPPFGNSSS 247
            ...|:.:...||    ....|.....|..||||..|.:.....|..:....|....||.||
Zfish   143 LPVQRSESFDPP----RARMTPPRPETPGGPPPPLPSAPRPFQSSTQSRGPPALPGTPRFG---- 199

  Fly   248 VKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTVSASTASLNSSLTSSTGS 312
               ::||
Zfish   200 ---SAPT---------------------------------------------------------- 203

  Fly   313 VRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPL-----QLPMKPA 372
                                              .||.|   .|...|.|||:     :.|..|:
Zfish   204 ----------------------------------PPPPT---LPGRQPAPPPVPGGIGRPPSVPS 231

  Fly   373 ISFGKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPL 437
            .|.|.....|.||     |...|:.||          |..|||
Zfish   232 PSTGHAGRPPPPP-----APGRGEDRP----------PPVPPA---------------------- 259

  Fly   438 QFHGSESSSPNTSAGSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQ 502
                      |.|.         |.:|.|  |||||.|:.|
Zfish   260 ----------NRSM---------PLTRDS--PPPPPPPSAS------------------------ 279

  Fly   503 SSAISSQAPSPPITQPPSSSSSSNSVAALRDQFRGGAGMSNGAPSPPLPP-TPAPSSNPSSASAS 566
            |......||||...:||.|:                        :||||| .|:|::........
Zfish   280 SKPTPPPAPSPACLRPPVSA------------------------APPLPPGRPSPNTPDEHTPRL 320

  Fly   567 PK---SLLRDNVKPIILNGGPLNPPAPPPHRSCPPPPPPQRQSSNQDRVKYWIDKTVYSFKKILH 628
            |:   ||..             :||||||.||.|.||||..:..
Zfish   321 PERNLSLAS-------------HPPAPPPGRSGPLPPPPSERPP--------------------- 351

  Fly   629 INRQGRH-SGESVKVINMLNSKRNGGSGSGSAPVPPQRHSSIRPNAPSTPPTHMANASHQFGSSS 692
              ..||: ||.|..:.....|.|.||....|:|.||             ||......:|:.||..
Zfish   352 --ALGRNASGRSGPLPPPPPSGRPGGGSMRSSPAPP-------------PPNRPGVETHRGGSRP 401

  Fly   693 GL-----SSGSGAGAAASVG------RLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSR 743
            .|     |||......|.:|      ..:::.|::|  .|..|::.|.|.|::..||.|||:
Zfish   402 PLPPDRPSSGPLPPPPAPIGNGYHSQHHIDEWESRF--TFRPVSDLPPPDPYIPCQKTYPSK 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vrp1	NP_001097406.1	None
wipf1b	XP_005165860.1	WH2_WAS_WASL-1	29..60	CDD:409219	16/36 (44%)
		actin-binding sequence	46..49	CDD:409219	2/2 (100%)