| Sequence 1: | NP_611639.1 | Gene: | Plekhm1 / 37520 | FlyBaseID: | FBgn0034694 | Length: | 720 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_055613.1 | Gene: | PLEKHM1 / 9842 | HGNCID: | 29017 | Length: | 1056 | Species: | Homo sapiens |
| Alignment Length: | 1065 | Identity: | 232/1065 - (21%) |
|---|---|---|---|
| Similarity: | 370/1065 - (34%) | Gaps: | 403/1065 - (37%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 18 VVKEALINTLNENAREIEFEVKQKSLEVLGVCEQTSA--LCTTLEALFLHGLKDSFLSATFNVIA 80
Fly 81 GDVERR-------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138
Fly 139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDLWT 203
Fly 204 PALKSCPIS-------SGVD---------VASSLGSDII-------AIPTPQPLQTNELFSESIS 245
Fly 246 NS--------------------------PFGRNSNFGV--PELSQRENLDLLIQKFDEMDVINEE 282
Fly 283 QTGGDKAETNETAEQ----------------EAP---------SGSKTRSRKKSNRQMDSSSFAD 322
Fly 323 LDLEAPSLLPQGSNSLSNLMQTS---WSGD---------------LEATPTSPTEE--LTGSRFF 367
Fly 368 Q-------RSVSVSSSVSLRSPTTDR--------------CSYNAL-----------------LR 394
Fly 395 KHES-----NRESGAG--------------------WSEIW-----EKFRASASN---------- 419
Fly 420 ---------------------------------------------------------LNVAQPQR 427
Fly 428 DTDPP------------ISED-------------------------------------------- 436
Fly 437 -------------LSDLQSLDT------------NSEFELLTSEF----------------DMVE 460
Fly 461 --------------------------------------LQQMVAQLCQLAREPGLDAQGFLCKSC 487
Fly 488 QHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSHPFL 552
Fly 553 DMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIHLYSIAD 617
Fly 618 LALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGAVFH 682
Fly 683 AEC-LNEKQPCPKCERIRKREDQGL 706 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Plekhm1 | NP_611639.1 | RUN | 54..185 | CDD:280855 | 42/139 (30%) |
| zf-RING_9 | 500..700 | CDD:290612 | 75/200 (38%) | ||
| PLEKHM1 | NP_055613.1 | RUN | 49..182 | CDD:280855 | 41/137 (30%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 215..245 | 5/29 (17%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 277..303 | 4/25 (16%) | |||
| Caprin-1_C | 306..>463 | CDD:289087 | 31/161 (19%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 360..422 | 12/64 (19%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 451..483 | 5/31 (16%) | |||
| PH_PLEKHM1 | 499..629 | CDD:241475 | 10/129 (8%) | ||
| LIR. /evidence=ECO:0000305 | 632..638 | 0/5 (0%) | |||
| Interaction with RAB7A. /evidence=ECO:0000269|PubMed:25500191 | 654..1056 | 102/405 (25%) | |||
| PH | 685..777 | CDD:214574 | 9/91 (10%) | ||
| zf-RING_9 | 846..1048 | CDD:290612 | 75/201 (37%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165144815 | |
| Domainoid | 1 | 1.000 | 193 | 1.000 | Domainoid score | I3193 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1829 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 282 | 1.000 | Inparanoid score | I2892 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D177737at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm40872 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_109012 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR12326 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R5810 |
| SonicParanoid | 1 | 1.000 | - | - | X6907 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.790 | |||||