Protein Alignment Plekhm1 and PLEKHM1

DIOPT Version :10

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_055613.1
• Gene: PLEKHM1 / 9842
• HGNCID: 29017
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 1065
• Identity: 232/1065 - (21%)
• Similarity: 370/1065 - (34%)
• Gaps: 403/1065 - (37%)

  Fly    18 VVKEALINTLNENAREIEFEVKQKSLEVLGVCEQTSA--LCTTLEALFLHGLKDSFLSATFNVIA 80
            |:|:.|:.::.      ..:.:..||:.:...|...|  :|:.|||:|:|||....:.|.    |
Human    17 VIKKKLVGSVK------ALQKQYVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAE----A 71

  Fly    81 GDVERR-------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138
            |...::       |:|.||.......||.:|.:::.|:.:.::.|:||||:|.:||:.:...||.
Human    72 GGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLK 136

  Fly   139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDLWT 203
            .:.:..:.|.:||:..||:||:|..|.....::.|.: :.|:|...|::||.|....|.||.|
Human   137 LLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTS-LSFELSYKSAILNEWTLTPLALSGL-- 198

  Fly   204 PALKSCPIS-------SGVD---------VASSLGSDII-------AIPTPQPLQTNELFSESIS 245
                 ||:|       ||.:         ::.|.||:.|       .|...|.|..:.|..::.|
Human   199 -----CPLSELDPLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHKIRRNQKLTASSLSLDTAS 258

  Fly   246 NS--------------------------PFGRNSNFGV--PELSQRENLDLLIQKFDEMDVINEE 282
            :|                          |...:|:.|.  .|.|.|...::|:: |.:..| |..
Human   259 SSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAEDSDRSLQEVLLE-FSKAQV-NSV 321

  Fly   283 QTGGDKAETNETAEQ----------------EAP---------SGSKTRSRKKSNRQMDSSSFAD 322
            .|.|...||.....|                |||         ||::.....:..|....|   .
Human   322 PTNGLSQETEIPTPQASLSLHGLNTSTYLHCEAPAEPLPAQAASGTQDGVHVQEPRPQAPS---P 383

  Fly   323 LDLEAPSLLPQGSNSLSNLMQTS---WSGD---------------LEATPTSPTEE--LTGSRFF 367
            |||:.|.....|....|.:.:|:   ..|:               :.::||||..:  ::...|:
Human   384 LDLQQPVESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFY 448

  Fly   368 Q-------RSVSVSSSVSLRSPTTDR--------------CSYNAL-----------------LR 394
            :       .|.|.....|.|.....|              ||..||                 .:
Human   449 RPSREQPLESASDHPIASYRGTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQAAPSQ 513

  Fly   395 KHES-----NRESGAG--------------------WSEIW-----EKFRASASN---------- 419
            .|:|     .|:.|..                    |.|::     .:||...||
Human   514 GHKSFRVVHRRQMGLSNPFRGLMKLGTVERRGAMGIWKELFCELSPLEFRLYLSNEEHTCVENCS 578

  Fly   420 ---------------------------------------------------------LNVAQPQR 427
                                                                     :||..|.:
Human   579 LLRCESVGPAHSDGRFELVFSGKKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNVQYPDQ 643

  Fly   428 DTDPP------------ISED-------------------------------------------- 436
            ..:||            :||.
Human   644 PEEPPEAPQGCLSPSDLLSEPAALQGTQFDWSSAQVPEPDAIKESLLYLYMDRTWMPYIFSLSLE 708

  Fly   437 -------------LSDLQSLDT------------NSEFELLTSEF----------------DMVE 460
                         |||...::|            .|.|:::|::.                |:|.
Human   709 ALKCFRIRNNEKMLSDSHGVETIRDILPDTSLGGPSFFKIITAKAVLKLQAGNAEEAALWRDLVR 773

  Fly   461 --------------------------------------LQQMVAQLCQLAREPGLDAQGFLCKSC 487
                                                  ||.:||    :..|.|||:||..|..|
Human   774 KVLASYLETAEEAVTLGGSLDENCQEVLKFATRENGFLLQYLVA----IPMEKGLDSQGCFCAGC 834

  Fly   488 QHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSHPFL 552
            ...:|..:...::|||||.|||:.|...:..:||||||:|||..|..:.::|..||.:.|:.|.:
Human   835 SRQIGFSFVRPKLCAFSGLYYCDICHQDDASVIPARIIHNWDLTKRPICRQALKFLTQIRAQPLI 899

  Fly   553 DMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIHLYSIAD 617
            ::|::|..:|...:.|..:...|.:|..:..||..|...:::.|..:...|.||.|..|.:|:||
Human   900 NLQMVNASLYEHVERMHLIGRRREQLKLLGDYLGLCRSGALKELSKRLNHRNYLLESPHRFSVAD 964

  Fly   618 LALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGAVFH 682
            |..|..||....|:...:....||..|.||..:||||:|||...:::||...||.||..|..|||
Human   965 LQQIADGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICQHHDIIFPFEFDTTVRCAECKTVFH 1029

  Fly   683 AEC-LNEKQPCPKCERIRKREDQGL 706
            ..| ...|:.||:|.|.||.::|.:
Human  1030 QSCQAVVKKGCPRCARRRKYQEQNI 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN_PLEKHM1	20..191	CDD:439041	50/179 (28%)
		zf-RING_9	500..700	CDD:464030	75/200 (38%)
PLEKHM1	NP_055613.1	RUN_PLEKHM1	18..188	CDD:439041	50/180 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..245		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..303		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..422		12/64 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..483		5/31 (16%)
		PH_PLEKHM1	499..629	CDD:241475	10/129 (8%)
		LIR. /evidence=ECO:0000305	632..638		0/5 (0%)
		Interaction with RAB7A. /evidence=ECO:0000269|PubMed:25500191	654..1056		102/405 (25%)
		PH	685..777	CDD:214574	9/91 (10%)
		zf-RING_9	846..1048	CDD:464030	75/201 (37%)