DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plekhm1 and RUBCN

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_006713890.1	Gene:	RUBCN / 9711	HGNCID:	28991	Length:	1012	Species:	Homo sapiens

Alignment Length:	751	Identity:	168/751 - (22%)
Similarity:	290/751 - (38%)	Gaps:	149/751 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TSALCTTLEALFLHGLKDSFLSATFNVIAGDVERRPEPSFWAPCMVFMHKQVIEQVQGLSQITSE 116
            :|.|.:.:||.::....||         .||....||                ....|.......
Human   296 SSTLTSPIEASWVSSQNDS---------PGDASEGPE----------------YLAIGNLDPRGR 335

  Fly   117 TGQCRAWV--RQSLNESVFS-----------SYLNNMRKNG-SALSQYYKRNALMRDSEGLETAA 167
            |..|::..  .:|.:.::||           |.|.:....| |.||...:|::.   ||| :|..
Human   336 TASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSF---SEG-QTLT 396

  Fly   168 KIMESLEAYVQFDL------------PVNSSLLNHWP---------------DYSLQLSDLWTPA 205
            ....:.:::::...            |.|.:::...|               .||.|.|::.||:
Human   397 VTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPS 461

  Fly   206 LKSCPISSGVDVASSLGSDIIAIPTPQPLQTNELFSESISNSPFG-------RNSNFGVPE---- 259
            ........|..:.|..|.      ..:|.:...|.| .:|...||       .|::|.:.|
Human   462 SLYMEYEGGRYLCSGEGM------FRRPSEGQSLIS-YLSEQDFGSCADLEKENAHFSISESLIA 519

  Fly   260 LSQRENLDLLIQKFDEMDVINEEQTGGDKAETNETAE---------------QEAPSG------S 303
            ..:....:::.|..:|.:| .||.:..:..|..:...               |||..|      |
Human   520 AIELMKCNMMSQCLEEEEV-EEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSS 583

  Fly   304 KTRSRKKSNRQMDSSSFADLDLEAPSLLPQGSNSLSNLMQTSWSGDLEATPTSPTEELTGSRFFQ 368
            .::...:.:.|:..|..||   |......|..:..|||...|.:| |..:..|    :......:
Human   584 SSQFSSRDSAQLSDSGSAD---EVDEFEIQDGSEGSNLTHISKNG-LSVSLAS----MFSDADIR 640

  Fly   369 RSVSVSSSVSLRSPTTDRCSYNALLRKHESNRESGA-GWSEIWEKFR-ASASNLNVAQPQRDTDP 431
            |:.:.||...:.|.:...|..      |.::.|:.| |..:.:|..: .:||.|....|:.|...
Human   641 RNTASSSKSFVSSQSFSHCFL------HSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQ 699

  Fly   432 ---------PISEDLSDLQSLDTNSEFELLTSEFDMVELQQMVAQLC-----QLAREPGLDAQGF 482
                     |||.|  |.|..|.   ::|.......:|......|:.     ...|:..:..|.:
Human   700 KLLPIPDSLPISPD--DGQHADI---YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNY 759

  Fly   483 LCKSCQHPLGIGY-SNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEF 546
            .|..|.......| ...:.|.:.|.|:|..|.:.....||:|::..|||.||.||..:...|.:.
Human   760 RCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKI 824

  Fly   547 RSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIH 611
            .:.|..::|.:|..:|.....:.:::.||::|..::....||..:. |||.:......:|.|.:|
Human   825 WNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAK-ELLDSFDTVPGHLTEDLH 888

  Fly   612 LYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQS-PRVLYPFHISTTFRCL 675
            |||:.||...::|.|..:|.:..:.|..||.:|.||..||||||.||: ..:::||.:.....|.
Human   889 LYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCE 953

  Fly   676 ACGAVFHAECLNEKQPCPKCERIRKREDQGLQEAVQ 711
            .|.|.:|..|. :...||:|||::.|.:...:::::
Human   954 ECKACYHKACF-KSGSCPRCERLQARREALARQSLE 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	27/156 (17%)
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	65/200 (33%)
RUBCN	XP_006713890.1	RUN	122..182	CDD:214736
RUBCN	XP_006713890.1	zf-RING_9	777..977	CDD:290612	65/201 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750