Protein Alignment Plekhm1 and RUBCNL

DIOPT Version :10

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_079389.2
• Gene: RUBCNL / 80183
• HGNCID: 20420
• Length: 662
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 170/704 - (24%)
• Similarity: 273/704 - (38%)
• Gaps: 172/704 - (24%)

  Fly    94 PCM----VFMHK-------QVIEQVQGL-SQITSETGQCRAWVRQSLNESVFSSYLNNMRKNGSA 146
            ||.    :..||       .|.:|.|.| ||:.:.......:|..:.:.|         ..:.|.
Human    39 PCQLDIRLMRHKAVWINPQDVQQQPQDLQSQVPAAGNSGTHFVTDAASPS---------GPSPSC 94

  Fly   147 LSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHW--PDYSLQLSDLWTPALKSC 209
            |........|..|:.....:|....|.|....|.|   ||...|.  |.||.::         |.
Human    95 LGDSLAETTLSEDTTDSVGSASPHGSSEKSSSFSL---SSTEVHMVRPGYSHRV---------SL 147

  Fly   210 PISSGVDVASSLGSDIIAIPTPQPLQTNELFSE-------------SISNSPFGRNS----NFGV 257
            |.|.|: :|:|          |.| :|:..|.|             .:|......||    .|.:
Human   148 PTSPGI-LATS----------PYP-ETDSAFFEPSHLTSAADEGAVQVSRRTISSNSFSPEVFVL 200

  Fly   258 PELSQREN-----LDLLIQKFDEM--DVINEEQT-----------GGDKAETNET----AEQEAP 300
            |...::||     .|::|...::|  ::::::||           |.|:.::..|    .:||
Human   201 PVDVEKENAHFYVADMIISAMEKMKCNILSQQQTESWSKEVSGLLGSDQPDSEMTFDTNIKQE-- 263

  Fly   301 SGSKTRSRK--------------KSNRQMDSSSFADLDLEAPSLLPQGS-NSLSNLMQTSWSGDL 350
            |||.|.|..              ::....|.......|::...:|..|. |.::.....|.|...
Human   264 SGSSTSSYSGYEGCAVLQVSPVTETRTYHDVKEICKCDVDEFVILELGDFNDITETCSCSCSSSK 328

  Fly   351 EAT--PTSPTEELTGS---RFFQRSVSVSSSVSLRSPTTDRCSYNALLRKHESNRESGAGWSEIW 410
            ..|  |...:.||...   |.||                 :|...:::....:...|.||...:.
Human   329 SVTYEPDFNSAELLAKELYRVFQ-----------------KCWILSVVNSQLAGSLSAAGSIVVN 376

  Fly   411 EKF--RASASNLNVAQP---------QRDTDPPISEDLSDLQSLDTNSEFELLTSEFDMVELQQM 464
            |:.  :...|::||.|.         ..|..||               .|:::.:....::...:
Human   377 EECVRKDFESSMNVVQEIKFKSRIRGTEDWAPP---------------RFQIIFNIHPPLKRDLV 426

  Fly   465 VAQLCQLAREPGLDAQGFLCKSCQHPLGIGY-SNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNW 528
            ||            ||.|.|..|..|:...: ...:.|.:.|.|:|:.|.......|||||:..|
Human   427 VA------------AQNFFCAGCGTPVEPKFVKRLRYCEYLGKYFCDCCHSYAESCIPARILMMW 479

  Fly   529 DFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTC--APS 591
            ||:||.||..:...|......|..::..:...:|..:..:..::.::.:|..|:..|.||  |.|
Human   480 DFKKYYVSNFSKQLLDSIWHQPIFNLLSIGQSLYAKAKELDRVKEIQEQLFHIKKLLKTCRFANS 544

  Fly   592 SIELLQNQFAGREYLYEHIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEI 656
            :::..: |..|  :|.:.:||:|:.||..|::|:|...|:...|...|||..|.||..||||||.
Human   545 ALKEFE-QVPG--HLTDELHLFSLEDLVRIKKGLLAPLLKDILKASLAHVAGCELCQGKGFICEF 606

  Fly   657 CQSPRVLYPFHISTTFRCLACGAVFHAECLNEKQPCPKCERIRKREDQGLQEAV 710
            ||:..|::||..:|..||.||.|.||.:|....: ||:|.||..|  :.|.|:|
Human   607 CQNTTVIFPFQTATCRRCSACRACFHKQCFQSSE-CPRCARITAR--RKLLESV 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN_PLEKHM1	20..191	CDD:439041	23/108 (21%)
		zf-RING_9	500..700	CDD:464030	71/201 (35%)
RUBCNL	NP_079389.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..131		17/84 (20%)
		Interaction with UVRAG. /evidence=ECO:0000269|PubMed:28306502	196..235		8/38 (21%)
		zf-RING_9	450..649	CDD:464030	71/202 (35%)