DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plekhm1 and plekhm2

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001124255.1	Gene:	plekhm2 / 564823	ZFINID:	ZDB-GENE-081022-169	Length:	994	Species:	Danio rerio

Alignment Length:	743	Identity:	157/743 - (21%)
Similarity:	270/743 - (36%)	Gaps:	209/743 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VKEALINTLNENAREIEFEVKQKSLEVLGVCE-QTSA----------LCTTLEALFLHGLKDSFL 72
            ||:.::..::.:.::::        .....|| :|.|          ||..|:...|:||:|
Zfish     6 VKDRILENISLSVKKLQ--------SYFAACEDETPAIRNHDRVLQRLCEHLDHALLYGLQD--- 59

  Fly    73 SATFNVIAGDVERRPEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYL 137
                 :.:|         :|...:.|..::.|.|::.|..|.:..|:.|||:..:||||...|||
Zfish    60 -----ISSG---------YWVLVLHFTRREAIRQIEELQHIATNLGRSRAWLYLALNESSLESYL 110

  Fly   138 NNMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLN---HWPDYSLQLS 199
            ....:|...|.:||.:|||:...:.|.....::..|| :::|:|.::...|:   :.|:|
Zfish   111 RLFEENQGLLQKYYYKNALVCSHDHLTLFLTLVSGLE-FIRFNLELDVPYLDVAPYMPEY----- 169

  Fly   200 DLWTPALKSCPISSGVDVASSL-GSDIIAIPTPQPLQTNELFSESISNSPFGRNSNFG--VPELS 261
              :.|       .:.:|....| .||.:::.:...|.:..|..:..:.:|...:.:||  .|.|.
Zfish   170 --YKP-------QNLLDFEERLPSSDSLSLHSFTSLTSTNLEWDDSAIAPSSEDYDFGDIFPVLQ 225

  Fly   262 QRENLDLLIQKFDEMDVINEEQTGGDKAET--NETAEQEAPSG---SKTRSRKKSNRQMDSSSFA 321
            ...:.|.  ::.|..|.::..::.|...:|  ::....:|.:|   :.:.||..:.||...:..:
Zfish   226 SLPSADW--EEGDLTDPVSGPRSSGSDPQTVVSDCVVVKASAGTIRTTSLSRSPTFRQNPFTEDS 288

  Fly   322 DLDLEAPSLLPQGSNSLSNLMQTSWSG-DLEATPT-----------SPTEELTGSRFFQRSVSVS 374
            |.:..| .:.|....|    ..||.:| |.|.|.|           .|.::..|     |..|||
Zfish   289 DTNTSA-DVTPVHIAS----RHTSTTGEDAEITSTELEVIRMARRRKPGKKRRG-----RGSSVS 343

  Fly   375 SSVSLRSP-TTDRCSY--------------------------------NALLRKHESNRESGAGW 406
            |..::.|| .||.|..                                |......|...|:|...
Zfish   344 SEQNVISPEVTDECLQIVVERDVTVNHITVDSRVPLERADSTASEPLRNGRREGEEEEPETGLRL 408

  Fly   407 SEIWEKFRASASNLNVAQPQRDTDPPISEDLSDLQSLDTNSEFELLTSEFDMVELQQMVAQLCQL 471
            .|:     ...|..||.||.|:    :.:.|:.  |||.....|.:.:..|....||...:  ..
Zfish   409 PEM-----TDTSMDNVGQPLRE----VMDRLNG--SLDAEDGAEEICTAHDGPPNQQPFRE--DA 460

  Fly   472 AREPGLDAQGFL----------CKSCQHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIY 526
            ..||...:.|||          |.:.|.|         ..|.||....:|....|.|.:|   :.
Zfish   461 GGEPPDPSDGFLQAPLPPADFYCFTSQSP---------DPAASGGGRHDSAGHGEPQDVP---VS 513

  Fly   527 NWDFRKYSVSKRAA----------------------------TFLAEFR---SHPFLDM------ 554
            |.|..:......||                            :..|||:   :|..|.|
Zfish   514 NEDEGEAEAEAAAAGQDPSIAIETSEKKLSQTEEDDEDATQSSHAAEFKVDNNHLLLLMIHVFRE 578

  Fly   555 --QLLNPRIYFASDAM-AELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIHLYSIA 616
              :.|...:..::..| .:||.|.:.|.  ..|:|        ||:...|.:.|..|....|:..
Zfish   579 NEEQLFKMVRMSTGHMEGDLQPLYLLLT--DCYIY--------LLRKGAAEKPYSVEEAVSYNEL 633

  Fly   617 D---LALIQRGV--LCQQLQKAFKLGEA 639
            |   :.|.|:.:  :|...::.|.|..|
Zfish   634 DYISVGLHQQTITLVCTNRRRQFLLDTA 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	38/140 (27%)
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	38/185 (21%)
plekhm2	NP_001124255.1	RUN	44..156	CDD:295434	37/129 (29%)
		PH_SKIP	748..850	CDD:270119
		PH	748..848	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900