Protein Alignment Plekhm1 and plekhm1

DIOPT Version :9

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001314780.1
• Gene: plekhm1 / 564048
• ZFINID: ZDB-GENE-030131-2752
• Length: 1058
• Species: Danio rerio
• Alignment Length: 1076
• Identity: 223/1076 - (20%)
• Similarity: 361/1076 - (33%)
• Gaps: 425/1076 - (39%)

  Fly    30 NAREIEFEVKQKSLEVLGVCE---------------QTSALCTTLEALFLHGLKDSFLSATFNVI 79
            :|::::..:|.|....|...:               :.:.||..|||:|:||:|..|:.:.
Zfish    12 DAKDVKQWIKGKIAHTLKALQKRYITTDTAVTSEDLEANLLCCALEAVFIHGIKSKFIRSD---- 72

  Fly    80 AGDVER------RPEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138
            .|.|.:      .|:|.|||......|:.|:::::.||.|.|:.|:||||||.:||:.:...||.
Zfish    73 GGQVRKGGSRGALPQPVFWALLKTVTHRDVVQELERLSFINSDVGRCRAWVRLALNDGLLECYLT 137

  Fly   139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDL-- 201
            ::.:..|.:|.||:..||:.|.|..|....:::.| |.:.|.|...|::||.|.:..|.|:.|
Zfish   138 SLLRENSKMSTYYQPGALLLDPEDREVLLTLLQGL-ASLTFQLSYKSAVLNEWTNTPLVLAGLCP 201

  Fly   202 -------------------------------WTP----------ALKSC--------------PI 211
                                           |||          .:..|              .:
Zfish   202 PTPADEQHLGPKRKESWDTVSQSSGGSGGSDWTPESLQRETRRDQIDGCDPSTPLTSSNLSLDTV 266

  Fly   212 SSGVDVASSLGSDIIAIPTPQPLQTNELFSES----ISNSPFGRNSN---FGVPELSQRENLDLL 269
            |....::|||.||.:       ||..||.|..    ..:|....|..   ....|...:|::|:.
Zfish   267 SGSSHLSSSLSSDSL-------LQGQELRSPEKERWSCDSEINHNEQQKITATEESLMKEDIDVF 324

  Fly   270 IQKFDEM-------------------------DVINEEQTGGDKAETNETAEQEAP--------- 300
            |...|.:                         ..|.|:.......||.|...:|:.
Zfish   325 IPAPDNLTDTHSVNEHTHIPDASLTSAQDTHHSHITEQSVENISVETKEETIEESEIIVKSTRLK 389

  Fly   301 ---SGSKTRSRKKSNRQMDSSSFADLDLEAPSLLPQGSNSLSNLMQTSWSGD--------LEATP 354
               :.|:|..::|.....|||      ::.|        |:|.|.:|..:.|        :.|.|
Zfish   390 AKNTVSETAEKEKKRESRDSS------VDPP--------SVSALTETEETPDPKDTVLSEISAAP 440

  Fly   355 TSPTEELTGSRFFQRSVSVSSSVSLRS----------------------------------PTTD 385
             ||.|....:...:.::|||..:|..|                                  |...
Zfish   441 -SPVETPQHAACRRTTMSVSRKISTDSLYSSCKSTSWISEEDFHKPEDLSISEAYAIIDVTPMNG 504

  Fly   386 RCS-------------------------YNALLRKHESNRESGAG-------------------- 405
            :.|                         :..||:..:..|.|..|
Zfish   505 QVSPVCEADELQPPPSVVHRRHNGLPNPFRGLLKLGQLERRSAVGMWWDYYCELSPFELRLYVNA 569

  Fly   406 ------------------------------------------------W---------------- 406
                                                            |
Zfish   570 EERVCNENLSLLRCEDIHLYSSTEGRFRLTFPNKRIYLRAPSKGEAEDWVDRITEAVNKLRPIMR 634

  Fly   407 SEIWEKFRASASNLNVAQPQRDT---------DPP------------------------------ 432
            .|.||....| |:..|..|...|         |||
Zfish   635 DEQWEVLHTS-SDQEVTSPAPSTPEHTISELPDPPQLDWTRHKDPEPDAIKEAVVYQSLEEKGWR 698

  Fly   433 ---------------ISED------------LSDL---QSLDTNSEFELLTSEFDMVELQ----- 462
                           :.||            :.|:   .||.:.:.|::||.. |.:.|:
Zfish   699 CLVLSLSLEILRGFQVREDSKTPLFSLPIGSIRDVVPDVSLGSPAFFKVLTVR-DTLTLRAESGE 762

  Fly   463 -------------------------------------------------QMVAQLCQLAREPGLD 478
                                                             :::..|..:..|.|||
Zfish   763 EARGWRSLIRGALDSYLETEDDGAGASAADGAQGGVVHKLVQHRLKGDGELLLHLSVVPIERGLD 827

  Fly   479 AQGFLCKSCQHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFL 543
            ||.:.|..|...:|:.....::|.|||..:|:||...:|.:||:|:::|||.:...||::|...|
Zfish   828 AQNYRCAGCSRQIGVSLGRGRLCEFSGQQFCDSCHQGDMSIIPSRMLHNWDLKTREVSRQAFKLL 892

  Fly   544 AEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYE 608
            .:....|.|::.:|||.::..:|.||::|:||.||.|:..|:..|.....:.:|.:...|.||.:
Zfish   893 TQIEHEPLLNLAVLNPELFEHADIMAKVQNLRQRLRFLGDYVLLCRSGFSKQIQPRLQQRTYLLD 957

  Fly   609 HIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFR 673
            :..:||:.||..|..|.....||...:.|..||..|.||..:||||:||.:|.:::||....|.|
Zfish   958 NSDVYSVLDLQQIADGHYESYLQSLIQFGSKHVHNCDLCTQRGFICQICNAPDIIFPFQFDVTSR 1022

  Fly   674 CLACGAVFHAECLNEKQPCPKCERIRKREDQGLQEA 709
            |..|..|||:.|..:...||:|.|.:|..::.|:|:
Zfish  1023 CNVCKTVFHSSCRAQCPVCPRCIRKQKYLERDLEES 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	47/136 (35%)
		zf-RING_9	500..700	CDD:290612	73/199 (37%)
plekhm1	NP_001314780.1	RUN	52..181	CDD:308412	47/133 (35%)
		PH-like	505..631	CDD:327399	7/125 (6%)
		PH-like	684..767	CDD:327399	10/83 (12%)
		zf-RING_9	849..1046	CDD:316423	72/196 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577999
Domainoid	1	1.000	92	1.000	Domainoid score	I7621
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2738
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26096
orthoMCL	1	0.900	-	-		OOG6_109012
Panther	1	1.100	-	-	LDO	PTHR12326
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900