DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plekhm1 and DEF8

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_011521462.1	Gene:	DEF8 / 54849	HGNCID:	25969	Length:	520	Species:	Homo sapiens

Alignment Length:	248	Identity:	63/248 - (25%)
Similarity:	110/248 - (44%)	Gaps:	66/248 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 PTEE------LTGSRFF-QRSVSVSSSVSLRSPTTDRCSYNALLRKHESNRESGAGWS--EIWEK 412
            |.|:      |...||: ::|.||..       |.|:|  |.::            |.  :.|..
Human   187 PNEDEPNIRVLLEHRFYKEKSKSVKQ-------TCDKC--NTII------------WGLIQTWYT 230

  Fly   413 -----FRASASNLNVAQPQRDTDPPISEDLSDLQSLDTNSEFELLTSEFDMVELQQMVAQLCQLA 472
                 :|..:..||:.     :.|.:|..:|.      .:|:||               .:|.
Human   231 CTGCYYRCHSKCLNLI-----SKPCVSSKVSH------QAEYEL---------------NICP-- 267

  Fly   473 REPGLDAQGFLCKSCQHPLGI-GY-SNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSV 535
             |.|||:|.:.|..|:.|:.: |. |..:.|.::|.|||:.|...::.:||||:::||||....|
Human   268 -ETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKV 331

  Fly   536 SKRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTC 588
            |:.:..:||...|.|.|.::.:||.::...:.:.|::.||..:..::.|..||
Human   332 SRCSMRYLALMVSRPVLRLREINPLLFSYVEELVEIRKLRQDILLMKPYFITC 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	29/89 (33%)
DEF8	XP_011521462.1	C1	200..253	CDD:294036	15/78 (19%)
DEF8	XP_011521462.1	zf-RING_9	295..>399	CDD:290612	29/90 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4753
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770