DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plekhm1 and DEF8

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_648549.1	Gene:	DEF8 / 39381	FlyBaseID:	FBgn0046296	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	249	Identity:	84/249 - (33%)
Similarity:	133/249 - (53%)	Gaps:	8/249 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 ELQQMVAQLCQLAREPGLDAQGFLCKSCQHPLGI--GYSNFQVCAFSGSYYCNSCMDVEMQLIPA 522
            |.|..::::|.   |.||.:||:.|..|...|.|  .:...::|.:||.|||..|...:...|||
  Fly   221 ERQHPISEICP---EIGLASQGYKCAECGTMLNIKNTWIEPRLCDYSGLYYCPRCNWNDSNFIPA 282

  Fly   523 RIIYNWDFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYT 587
            |||:||||....||:.|...:..|.:.|.:.::..||:::...:.:..::.||..|..:|.||..
  Fly   283 RIIHNWDFSPRRVSRTALQEIRLFLNKPLIRLEEDNPKLFVFVEKLCAVKKLRQNLVHMRHYLAA 347

  Fly   588 C-APSSIELLQNQFAGREYLYEHIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKG 651
            | ..|.::|:..|...|.:|.:....||::||:.::.|.|.:.||..||....|:..|.:|..:.
  Fly   348 CKIASELKLVDQQLGVRRHLAQSNEFYSLSDLSQVESGALSEFLQGVFKAFNDHIRSCPMCLAQA 412

  Fly   652 FICEICQSPRVLYPFHISTTFRCLACGAVFHAECLNEKQP-CPKCERIRKREDQ 704
            :|||||.:..|::||. ....:|..|.::||..||..|.. ||||.||::|..|
  Fly   413 YICEICSNNEVIFPFD-DGCIKCDQCNSIFHRVCLTRKNMICPKCIRIQERRLQ 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	70/201 (35%)
DEF8	NP_648549.1	C1	173..214	CDD:197519
DEF8	NP_648549.1	zf-RING_9	259..461	CDD:290612	70/202 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445274
Domainoid	1	1.000	97	1.000	Domainoid score	I2433
eggNOG	1	0.900	-	-		E1_KOG1829
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4753
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3402
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12326
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800