DRSC/TRiP Functional Genomics Resources

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Protein Alignment Plekhm1 and Plekhm1

DIOPT Version :9

Sequence 1:NP_611639.1 Gene:Plekhm1 / 37520 FlyBaseID:FBgn0034694 Length:720 Species:Drosophila melanogaster
Sequence 2:NP_898855.1 Gene:Plekhm1 / 353047 MGIID:2443207 Length:1074 Species:Mus musculus


Alignment Length:1095 Identity:227/1095 - (20%)
Similarity:371/1095 - (33%) Gaps:444/1095 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 VVKEALINTLNENAREIEFEVKQKSLEVLGVCEQTSA--LCTTLEALFLHGLKDSFLSATFNVIA 80
            |:|:.|:.::.      ..:.:..||:.:...|...|  :|:.|||:|:|||....:.|.    |
Mouse    16 VIKKKLVGSVK------ALQKQHVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAE----A 70

  Fly    81 GDVERR-------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138
            |...::       |:|.||.......|:.::..::.|..|.::.|:||||:|.:||:.:...||.
Mouse    71 GGKRKKHTHQKALPQPVFWPLLKAITHRHIVSDLEHLVFINTDVGRCRAWLRLALNDGLMECYLK 135

  Fly   139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDLWT 203
            .:.:..:.|.:||:..||:||:|..|.....::.|.: :.|:|...|::||.|....|.||.|  
Mouse   136 LLLQEPARLCEYYQPTALLRDAEEAEFLLSFLQGLTS-LSFELSYKSAILNEWTLTPLSLSGL-- 197

  Fly   204 PALKSCPIS-------SGVD---------VASSLGSDII--------------------AIPTPQ 232
                 ||:|       ||.:         ::.|.||:.|                    ::.|..
Mouse   198 -----CPLSELDPLTTSGAELQRKESLDSISHSSGSEDIEVQHSGHKIRRNRKLTASSLSLDTAS 257

  Fly   233 P-------------LQTNELFSESISNSPFGRNSNFGV-----PELSQRENLDLLIQKFDEMDVI 279
            .             ||.|...|...|..|...:|:.|:     |:.|.:|    ::.:|.:..| 
Mouse   258 SSQLSCSLNSDSCLLQENGPKSPDHSEEPMSYDSDLGMANTDDPDRSLQE----VLSEFSKAQV- 317

  Fly   280 NEEQTGGDKAETN---------------------ETAEQEAP----SGSKTRSRK--------KS 311
            |...:.|...|.:                     |.:|:..|    ||:.:...|        ..
Mouse   318 NSAPSSGPNQEPDTPMFQTPLSLHSLATSTHLHFEGSEELFPAHKSSGTSSGGHKHQLLPQETPD 382

  Fly   312 NRQMDSS------SFADLDLEAP--SLLPQGS-----------------NSLSNLMQTSW-SGDL 350
            .:|:.::      |.:|....:|  ....|||                 :|.::....|| |.|.
Mouse   383 EKQLGTAQAGPAQSTSDQQPSSPVGGAAGQGSGPWKALEYGRVGPKLVVSSPTSPKGKSWISEDD 447

  Fly   351 EATP-------------TSPTEELTGSRFFQRSVSVSSSVSLRSPTTD----RCSYNAL------ 392
            ...|             |||.::...||           .:|..|.:.    .||..||      
Mouse   448 FCRPPQEPALKSAAGLCTSPVQDTPESR-----------AALHGPFSQGPRKSCSLGALDKACVP 501

  Fly   393 ---------------------------LRKHES-----NRESG----------------AGWSEI 409
                                       .:.|::     .|:.|                .|...|
Mouse   502 SQACGNAQPAPAPAPAPAPAPAPAPGVTQDHKNFCVVHRRQMGLSNPFRGLMKLGTVARRGAMGI 566

  Fly   410 WEKF----------------------------------------------------RASASN--- 419
            |::|                                                    |||:.:   
Mouse   567 WKEFFCELSPLEFRLYLSDEERTCVESCSLLRCEAVGPAHSDGRFELVFSGKKLALRASSQDEAE 631

  Fly   420 ---------------------LNVAQPQR---------DTDPPIS-------------------- 434
                                 :|:..|.:         |:.||.|                    
Mouse   632 DWLDRVREALQKVRPQQEDEWVNIQYPDQAEDAPEAPPDSLPPYSTLLPEPAGAQGMQLDWTSAQ 696

  Fly   435 -----------------------------------------EDLSDLQSLDTNSE---------- 448
                                                     :.|||...::|..:          
Mouse   697 VPEPDAIKESLLYLYADRTWVPYIFSLSLESLKCFRVRNNEKMLSDSHGVETIRDILPDTSLGGP 761

  Fly   449 --FELLTSEF----------------DMVE----------------------------------- 460
              |:::|::.                |:|.                                   
Mouse   762 AFFKIITAKAVLKLQAKNTEEATHWRDLVRKVLASYLESAEEAVTLGGSLDEKCQEVLKFATREN 826

  Fly   461 ---LQQMVAQLCQLAREPGLDAQGFLCKSCQHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPA 522
               ||.:||    :..|.|||:||..|..|...:|..:...::|||||.|||:.|...:..:|||
Mouse   827 GFLLQYLVA----IPTEKGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPA 887

  Fly   523 RIIYNWDFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYT 587
            |||:|||..|..|.::|..|||:.|:.|.:::||:|..:|...:.|..:...|.:|..:..||..
Mouse   888 RIIHNWDLTKRPVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSREQLKLLGDYLGL 952

  Fly   588 CAPSSIELLQNQFAGREYLYEHIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGF 652
            |...:::.|..:.:.|.||.|..|.:|:|||..|..||....|:...:....||..|.||..:||
Mouse   953 CRSGALKELCKRLSHRNYLLESPHRFSVADLQQIAEGVYEGFLKALIEFASQHVYHCDLCTQRGF 1017

  Fly   653 ICEICQSPRVLYPFHISTTFRCLACGAVFHAEC-LNEKQPCPKCERIRKREDQGL 706
            ||:||....:::||...||.||..|..|||..| ...::.||:|.|.||.::|.:
Mouse  1018 ICQICHHQDIIFPFEFDTTVRCAECRTVFHQSCQAVVRKGCPRCARRRKYQEQNV 1072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Plekhm1NP_611639.1 RUN 54..185 CDD:280855 41/139 (29%)
zf-RING_9 500..700 CDD:290612 76/200 (38%)
Plekhm1NP_898855.1 RUN 48..181 CDD:280855 42/141 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..244 9/71 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..336 17/121 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..454 26/287 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..526 9/19 (47%)
PH_PLEKHM1 529..646 CDD:241475 36/116 (31%)
LIR. /evidence=ECO:0000250|UniProtKB:Q9Y4G2 649..655 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..680 8/18 (44%)
Interaction with RAB7A. /evidence=ECO:0000250|UniProtKB:Q9Y4G2 672..1074 13/34 (38%)
PH 703..795 CDD:214574 0/2 (0%)
zf-RING_9 864..1066 CDD:290612


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834927
Domainoid 1 1.000 77 1.000 Domainoid score I8854
eggNOG 1 0.900 - - E1_KOG1829
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 278 1.000 Inparanoid score I2907
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177737at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42944
orthoMCL 1 0.900 - - OOG6_109012
Panther 1 1.100 - - LDO PTHR12326
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5810
SonicParanoid 1 1.000 - - X6907
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.790

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