Protein Alignment Plekhm1 and Plekhm1

DIOPT Version :10

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_898855.1
• Gene: Plekhm1 / 353047
• MGIID: 2443207
• Length: 1074
• Species: Mus musculus
• Alignment Length: 1095
• Identity: 227/1095 - (20%)
• Similarity: 371/1095 - (33%)
• Gaps: 444/1095 - (40%)

  Fly    18 VVKEALINTLNENAREIEFEVKQKSLEVLGVCEQTSA--LCTTLEALFLHGLKDSFLSATFNVIA 80
            |:|:.|:.::.      ..:.:..||:.:...|...|  :|:.|||:|:|||....:.|.    |
Mouse    16 VIKKKLVGSVK------ALQKQHVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAE----A 70

  Fly    81 GDVERR-------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138
            |...::       |:|.||.......|:.::..::.|..|.::.|:||||:|.:||:.:...||.
Mouse    71 GGKRKKHTHQKALPQPVFWPLLKAITHRHIVSDLEHLVFINTDVGRCRAWLRLALNDGLMECYLK 135

  Fly   139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDLWT 203
            .:.:..:.|.:||:..||:||:|..|.....::.|.: :.|:|...|::||.|....|.||.|
Mouse   136 LLLQEPARLCEYYQPTALLRDAEEAEFLLSFLQGLTS-LSFELSYKSAILNEWTLTPLSLSGL-- 197

  Fly   204 PALKSCPIS-------SGVD---------VASSLGSDII--------------------AIPTPQ 232
                 ||:|       ||.:         ::.|.||:.|                    ::.|..
Mouse   198 -----CPLSELDPLTTSGAELQRKESLDSISHSSGSEDIEVQHSGHKIRRNRKLTASSLSLDTAS 257

  Fly   233 P-------------LQTNELFSESISNSPFGRNSNFGV-----PELSQRENLDLLIQKFDEMDVI 279
            .             ||.|...|...|..|...:|:.|:     |:.|.:|    ::.:|.:..|
Mouse   258 SSQLSCSLNSDSCLLQENGPKSPDHSEEPMSYDSDLGMANTDDPDRSLQE----VLSEFSKAQV- 317

  Fly   280 NEEQTGGDKAETN---------------------ETAEQEAP----SGSKTRSRK--------KS 311
            |...:.|...|.:                     |.:|:..|    ||:.:...|        ..
Mouse   318 NSAPSSGPNQEPDTPMFQTPLSLHSLATSTHLHFEGSEELFPAHKSSGTSSGGHKHQLLPQETPD 382

  Fly   312 NRQMDSS------SFADLDLEAP--SLLPQGS-----------------NSLSNLMQTSW-SGDL 350
            .:|:.::      |.:|....:|  ....|||                 :|.::....|| |.|.
Mouse   383 EKQLGTAQAGPAQSTSDQQPSSPVGGAAGQGSGPWKALEYGRVGPKLVVSSPTSPKGKSWISEDD 447

  Fly   351 EATP-------------TSPTEELTGSRFFQRSVSVSSSVSLRSPTTD----RCSYNAL------ 392
            ...|             |||.::...||           .:|..|.:.    .||..||
Mouse   448 FCRPPQEPALKSAAGLCTSPVQDTPESR-----------AALHGPFSQGPRKSCSLGALDKACVP 501

  Fly   393 ---------------------------LRKHES-----NRESG----------------AGWSEI 409
                                       .:.|::     .|:.|                .|...|
Mouse   502 SQACGNAQPAPAPAPAPAPAPAPAPGVTQDHKNFCVVHRRQMGLSNPFRGLMKLGTVARRGAMGI 566

  Fly   410 WEKF----------------------------------------------------RASASN--- 419
            |::|                                                    |||:.:
Mouse   567 WKEFFCELSPLEFRLYLSDEERTCVESCSLLRCEAVGPAHSDGRFELVFSGKKLALRASSQDEAE 631

  Fly   420 ---------------------LNVAQPQR---------DTDPPIS-------------------- 434
                                 :|:..|.:         |:.||.|
Mouse   632 DWLDRVREALQKVRPQQEDEWVNIQYPDQAEDAPEAPPDSLPPYSTLLPEPAGAQGMQLDWTSAQ 696

  Fly   435 -----------------------------------------EDLSDLQSLDTNSE---------- 448
                                                     :.|||...::|..:
Mouse   697 VPEPDAIKESLLYLYADRTWVPYIFSLSLESLKCFRVRNNEKMLSDSHGVETIRDILPDTSLGGP 761

  Fly   449 --FELLTSEF----------------DMVE----------------------------------- 460
              |:::|::.                |:|.
Mouse   762 AFFKIITAKAVLKLQAKNTEEATHWRDLVRKVLASYLESAEEAVTLGGSLDEKCQEVLKFATREN 826

  Fly   461 ---LQQMVAQLCQLAREPGLDAQGFLCKSCQHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPA 522
               ||.:||    :..|.|||:||..|..|...:|..:...::|||||.|||:.|...:..:|||
Mouse   827 GFLLQYLVA----IPTEKGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPA 887

  Fly   523 RIIYNWDFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYT 587
            |||:|||..|..|.::|..|||:.|:.|.:::||:|..:|...:.|..:...|.:|..:..||..
Mouse   888 RIIHNWDLTKRPVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSREQLKLLGDYLGL 952

  Fly   588 CAPSSIELLQNQFAGREYLYEHIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGF 652
            |...:::.|..:.:.|.||.|..|.:|:|||..|..||....|:...:....||..|.||..:||
Mouse   953 CRSGALKELCKRLSHRNYLLESPHRFSVADLQQIAEGVYEGFLKALIEFASQHVYHCDLCTQRGF 1017

  Fly   653 ICEICQSPRVLYPFHISTTFRCLACGAVFHAEC-LNEKQPCPKCERIRKREDQGL 706
            ||:||....:::||...||.||..|..|||..| ...::.||:|.|.||.::|.:
Mouse  1018 ICQICHHQDIIFPFEFDTTVRCAECRTVFHQSCQAVVRKGCPRCARRRKYQEQNV 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN_PLEKHM1	20..191	CDD:439041	49/179 (27%)
		zf-RING_9	500..700	CDD:464030	76/200 (38%)
Plekhm1	NP_898855.1	RUN_PLEKHM1	17..187	CDD:439041	47/178 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..244		9/71 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..336		17/121 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..454		26/287 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..526		9/19 (47%)
		PH_PLEKHM1	529..646	CDD:241475	36/116 (31%)
		LIR. /evidence=ECO:0000250|UniProtKB:Q9Y4G2	649..655		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..680		8/18 (44%)
		Interaction with RAB7A. /evidence=ECO:0000250|UniProtKB:Q9Y4G2	672..1074		13/34 (38%)
		PH	703..795	CDD:214574	0/2 (0%)
		zf-RING_9	864..1066	CDD:464030