DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plekhm1 and Rubicon

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001259348.1	Gene:	Rubicon / 31803	FlyBaseID:	FBgn0030055	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	869	Identity:	178/869 - (20%)
Similarity:	309/869 - (35%)	Gaps:	265/869 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRENVVKEALINTLNENAREIEFEVK-QKSLEVLGVCEQTSALCT------TLEALFLHGLKD-- 69
            :::.:.:.:|:..|.   |...|..: .||.:.|.:..|:   ||      .|:.:.|..|.|
  Fly    41 QQQQLARNSLLADLR---RSTNFWFRAAKSTDGLQLLAQS---CTRILQHGLLQPVELRRLADDF 99

  Fly    70 SFLSATFNVIAGDVERRPEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFS 134
            .||.|:    ||..:::.:|..:.|  .:..:.....|.|:.:...|      |..:.|.....|
  Fly   100 EFLLAS----AGKQQQQTKPQPYRP--DYAARDSASMVNGVEEFLGE------WTTRCLRARCLS 152

  Fly   135 SYLNN------------------MRKNGSALSQYYKRNALMRDSEGLETAAKIMESLE-----AY 176
            ..|..                  :|::|.|.:.:....|:..:..||.:..::...:.     :.
  Fly   153 QCLQTLVSDPELMELYYPSEEAFLRRSGDATALFVCLTAVQLNQSGLLSQLEVRHQVRHRRTCSQ 217

  Fly   177 VQFDLPVNSSLLNHWPDYSLQLSDLWTPALKSCPISSGVDVASSLGSDIIAIPTPQPLQTNELFS 241
            ..|.:   |..|...|:..|| ..::...|||.|..|..|               :.|.....|.
  Fly   218 PNFSI---SPKLQAVPEERLQ-KRIFLRRLKSLPNLSQED---------------EELDDRAAFR 263

  Fly   242 E-----SISNSPFGRNSNFGVPELSQRENLD----LLIQKFDEMDVINEEQTGGDKAETNETAEQ 297
            .     |.|.|...|..:...|..|...:.|    :.:...|::.:..::.......|.:|..:|
  Fly   264 RRCQTFSSSRSHKLREDHLDAPSTSSCSSHDSPRRIQLINCDDIKIWTDQTPQEVPEEVHEKLQQ 328

  Fly   298 EAPS------------GSKTRSRKKSNRQM--DSSSFAD---LD----------------LEAPS 329
            .:.:            ||........:|.:  |.::..|   ||                .|..|
  Fly   329 ASKASTSVGGYLGSFFGSPPLYTSWFHRGVGDDLNASGDGGMLDTFLPVNGRKLKKQHTLFEGVS 393

  Fly   330 LLPQGSNSLSNLMQTSWSGDLEATPTSPTEELTGSRFFQRSVSVSSSVSLRSPTTDR------CS 388
            :|.:.::|.:.:....|  |::.:....|          .|.:.|||||: :|.:|:      .|
  Fly   394 MLDEAASSTACISSAPW--DIQGSAGDST----------TSTTASSSVSI-TPGSDKMDQQSLAS 445

  Fly   389 YNALLRKHESNRESGAGWSEIWEK----FRASASNL----NVAQPQRDTDP--PISEDLSD---- 439
            :..:.|:..:|.:        .||    ||.|.:.:    :|...:|...|  |.|.:||:
  Fly   446 FLQMSRQTHNNTQ--------LEKENAHFRISEACITAIEHVKWSRRLATPAGPTSHNLSEPNLM 502

  Fly   440 --------------------LQSLDTNSEFEL--------LTSEFDMVELQQMVAQLCQL----- 471
                                ||.:...||.:|        |.||      |:...||..|
  Fly   503 PYAEQIPGGGMQNHSAEAVGLQLISRFSEQQLPRLGHLKWLVSE------QEAPQQLLPLPTPKQ 561

  Fly   472 -----------------------------AREPGLDAQGFLCKSC---------QHPLGIGYSNF 498
                                         :|...|..|...|..|         ||        |
  Fly   562 DHEQASLTRGTSSWAPPRQQIIFTEHPSESRSKVLQKQNHRCAGCGMRVAKHLQQH--------F 618

  Fly   499 QVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYF 563
            :.|.:.|.|.|..|...::..|||||:.:||||.|.|...|...:.:..:.|...:..||.::|.
  Fly   619 RYCTYLGKYLCTGCHRNQISAIPARILRSWDFRCYPVCSFAYRLIEQMYAFPLFHVPDLNSQLYK 683

  Fly   564 ASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLY-----EHI----HLYSIADLA 619
            ..: :|:.:..|::|..::.::..|          :||.||..:     .||    .::|:.|..
  Fly   684 HKE-LAKARKRRLQLQAVKGFIANC----------RFATREQSFFNAIPAHITQDPDMWSMCDFV 737

  Fly   620 LIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGAVFH-- 682
            .:|...:.:.:::...|.|.||..|.||..:.|:||.|:...::||:..... ||..|||.||
  Fly   738 DVQNTSMNRSIKEVIALSEQHVHNCVLCTGRAFVCEHCKGGELIYPWQRKVQ-RCDRCGACFHNG 801

  Fly   683 -----AECLNEKQPCPKCERIRKR 701
                 :.|.|:..|||:|.|::.|
  Fly   802 CWKVRSRCRNQNDPCPRCSRLQSR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	27/161 (17%)
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	61/215 (28%)
Rubicon	NP_001259348.1	zf-RING_9	619..824	CDD:290612	61/216 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3402
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750