Protein Alignment Plekhm1 and Rubicon

DIOPT Version :10

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_572496.1
• Gene: Rubicon / 31803
• FlyBaseID: FBgn0030055
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 869
• Identity: 178/869 - (20%)
• Similarity: 309/869 - (35%)
• Gaps: 265/869 - (30%)

  Fly    14 KRENVVKEALINTLNENAREIEFEVK-QKSLEVLGVCEQTSALCT------TLEALFLHGLKD-- 69
            :::.:.:.:|:..|.   |...|..: .||.:.|.:..|:   ||      .|:.:.|..|.|
  Fly    41 QQQQLARNSLLADLR---RSTNFWFRAAKSTDGLQLLAQS---CTRILQHGLLQPVELRRLADDF 99

  Fly    70 SFLSATFNVIAGDVERRPEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFS 134
            .||.|:    ||..:::.:|..:.|  .:..:.....|.|:.:...|      |..:.|.....|
  Fly   100 EFLLAS----AGKQQQQTKPQPYRP--DYAARDSASMVNGVEEFLGE------WTTRCLRARCLS 152

  Fly   135 SYLNN------------------MRKNGSALSQYYKRNALMRDSEGLETAAKIMESLE-----AY 176
            ..|..                  :|::|.|.:.:....|:..:..||.:..::...:.     :.
  Fly   153 QCLQTLVSDPELMELYYPSEEAFLRRSGDATALFVCLTAVQLNQSGLLSQLEVRHQVRHRRTCSQ 217

  Fly   177 VQFDLPVNSSLLNHWPDYSLQLSDLWTPALKSCPISSGVDVASSLGSDIIAIPTPQPLQTNELFS 241
            ..|.:   |..|...|:..|| ..::...|||.|..|..|               :.|.....|.
  Fly   218 PNFSI---SPKLQAVPEERLQ-KRIFLRRLKSLPNLSQED---------------EELDDRAAFR 263

  Fly   242 E-----SISNSPFGRNSNFGVPELSQRENLD----LLIQKFDEMDVINEEQTGGDKAETNETAEQ 297
            .     |.|.|...|..:...|..|...:.|    :.:...|::.:..::.......|.:|..:|
  Fly   264 RRCQTFSSSRSHKLREDHLDAPSTSSCSSHDSPRRIQLINCDDIKIWTDQTPQEVPEEVHEKLQQ 328

  Fly   298 EAPS------------GSKTRSRKKSNRQM--DSSSFAD---LD----------------LEAPS 329
            .:.:            ||........:|.:  |.::..|   ||                .|..|
  Fly   329 ASKASTSVGGYLGSFFGSPPLYTSWFHRGVGDDLNASGDGGMLDTFLPVNGRKLKKQHTLFEGVS 393

  Fly   330 LLPQGSNSLSNLMQTSWSGDLEATPTSPTEELTGSRFFQRSVSVSSSVSLRSPTTDR------CS 388
            :|.:.::|.:.:....|  |::.:....|          .|.:.|||||: :|.:|:      .|
  Fly   394 MLDEAASSTACISSAPW--DIQGSAGDST----------TSTTASSSVSI-TPGSDKMDQQSLAS 445

  Fly   389 YNALLRKHESNRESGAGWSEIWEK----FRASASNL----NVAQPQRDTDP--PISEDLSD---- 439
            :..:.|:..:|.:        .||    ||.|.:.:    :|...:|...|  |.|.:||:
  Fly   446 FLQMSRQTHNNTQ--------LEKENAHFRISEACITAIEHVKWSRRLATPAGPTSHNLSEPNLM 502

  Fly   440 --------------------LQSLDTNSEFEL--------LTSEFDMVELQQMVAQLCQL----- 471
                                ||.:...||.:|        |.||      |:...||..|
  Fly   503 PYAEQIPGGGMQNHSAEAVGLQLISRFSEQQLPRLGHLKWLVSE------QEAPQQLLPLPTPKQ 561

  Fly   472 -----------------------------AREPGLDAQGFLCKSC---------QHPLGIGYSNF 498
                                         :|...|..|...|..|         ||        |
  Fly   562 DHEQASLTRGTSSWAPPRQQIIFTEHPSESRSKVLQKQNHRCAGCGMRVAKHLQQH--------F 618

  Fly   499 QVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSHPFLDMQLLNPRIYF 563
            :.|.:.|.|.|..|...::..|||||:.:||||.|.|...|...:.:..:.|...:..||.::|.
  Fly   619 RYCTYLGKYLCTGCHRNQISAIPARILRSWDFRCYPVCSFAYRLIEQMYAFPLFHVPDLNSQLYK 683

  Fly   564 ASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLY-----EHI----HLYSIADLA 619
            ..: :|:.:..|::|..::.::..|          :||.||..:     .||    .::|:.|..
  Fly   684 HKE-LAKARKRRLQLQAVKGFIANC----------RFATREQSFFNAIPAHITQDPDMWSMCDFV 737

  Fly   620 LIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGAVFH-- 682
            .:|...:.:.:::...|.|.||..|.||..:.|:||.|:...::||:..... ||..|||.||
  Fly   738 DVQNTSMNRSIKEVIALSEQHVHNCVLCTGRAFVCEHCKGGELIYPWQRKVQ-RCDRCGACFHNG 801

  Fly   683 -----AECLNEKQPCPKCERIRKR 701
                 :.|.|:..|||:|.|::.|
  Fly   802 CWKVRSRCRNQNDPCPRCSRLQSR 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN_PLEKHM1	20..191	CDD:439041	37/202 (18%)
		zf-RING_9	500..700	CDD:464030	61/215 (28%)
Rubicon	NP_572496.1	RUN_RUBCN	50..207	CDD:439048	34/174 (20%)
		zf-RING_9	619..824	CDD:464030	61/216 (28%)