DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plekhm1 and Rubcn

DIOPT Version :9

Sequence 1:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_006521715.1	Gene:	Rubcn / 100502698	MGIID:	1915160	Length:	981	Species:	Mus musculus

Alignment Length:	818	Identity:	183/818 - (22%)
Similarity:	297/818 - (36%)	Gaps:	198/818 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EALFLHGLKDSFLSATFNVIAGDVERRPEPSFWAPCMVFMHKQ----VIEQVQGLSQITSETGQC 120
            |..||  |.|:.::|....:....:..|.........:|..||    ::.:.|.|:.:...|...
Mouse   156 ETAFL--LSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKQESPLLVTKSQSLTALPGSTYTP 218

  Fly   121 RAWVRQ--------SLNESVFSSYLNNMRKNGSALS----QYYKRNALMRDSEGLETAAKIMESL 173
            .|...|        ||.....||:.:..|....:||    |..:....:..:|...|.|
Mouse   219 PASYAQHSYFGSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQEDRECLSPAETQTTPA------ 277

  Fly   174 EAYVQFDLPVNSSLLNHWPDYSLQLSD-LWTPALKSCPISSGVDVAS--SLGSDIIAIPTPQPLQ 235
                  .||.:|:|....|..:.::|| ..|..|::..:||..|..|  |.|.:.:||..|.|
Mouse   278 ------PLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPAP-- 334

  Fly   236 TNELFSESISNSPFGRNSNFGVPELSQRENLDLLIQKFDEMDVINEEQTGGDKAETNETAEQEAP 300
             :...:...|:|..|.:|:..:...|..:.|:.......:.:...:.|.|.....::.:..|.||
Mouse   335 -HGRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEGQTAP 398

  Fly   301 --SGSK---TRSRKKSN------------------------------------------------ 312
              ||:|   .||...:|
Mouse   399 VASGTKKSHIRSHSDTNIASRGAAGGPRNITIIVEDPIAEGGQYLCSGEGMFRRPSEGQSLISYL 463

  Fly   313 RQMDSSSFADLDLE--------------------------------------------------- 326
            .:.|..|.|||:.|
Mouse   464 SEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRR 528

  Fly   327 ----APSLLP---------------------QGSNSLSNLMQTSWSGDLEATPTSPTEELTGSRF 366
                ..:|||                     :.|..||.......:.|||....|....||....
Mouse   529 QQIRTKNLLPAYRETENGSFRVTSSSSQFSSRDSTQLSESGSAEDADDLEIQDGSEGSNLTPMLQ 593

  Fly   367 FQRSVSVSSSVS----LRSPTTD-RCSYNALLRK---HESNRESGA-GWSEIWEKFR-ASASNLN 421
            ...||||:|..|    .||..:: :.|::..|..   |.::.|:.| |..:.:|..: .:||.|.
Mouse   594 NGLSVSVASLFSDADIRRSAVSNGKSSFSQNLSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELE 658

  Fly   422 VAQPQRDTDP---------PISEDLSDLQSLDTNSEFELLTSEFDMVELQQMVAQLC-----QLA 472
            ...|:.|...         |||.|  |.|..|.   ::|.......:|......|:.     ...
Mouse   659 WLVPEHDAPQKLLPIPDSLPISPD--DGQHADI---YKLRIRVRGNLEWAPPRPQIIFNVHPAPT 718

  Fly   473 REPGLDAQGFLCKSCQHPLGIGY-SNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVS 536
            |:..:..|.:.|..|.......| ...:.|.:.|.|:|..|.:....::|:||:..|||.||.||
Mouse   719 RKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVS 783

  Fly   537 KRAATFLAEFRSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFA 601
            ..:...|.:..:.|..::|.:|..:|.....:.:::.||::|..::....||..:. |||.:...
Mouse   784 NFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLYHMKNMFKTCRLAK-ELLDSFDV 847

  Fly   602 GREYLYEHIHLYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPR-VLYP 665
            ...:|.|.:||||::||...::|.|..:|.:..:.|.|||.:|.||..||||||.||:.. |::|
Mouse   848 VPGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEFCQNEEDVIFP 912

  Fly   666 FHISTTFRCLACGAVFHAECLNEKQPCPKCERIRKRED 703
            |.:.....|..|.|.:|..|....: ||:|||::.|.:
Mouse   913 FELHKCRTCEECKACYHKTCFKSGR-CPRCERLQARRE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	28/140 (20%)
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	67/200 (34%)
Rubcn	XP_006521715.1	RUN	123..183	CDD:214736	7/28 (25%)
		DUF4679	181..>304	CDD:374056	28/134 (21%)
		APC_basic	204..>426	CDD:368684	52/236 (22%)
		zf-RING_9	747..943	CDD:372797	65/197 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750