Protein Alignment Plekhm1 and plekhm1

DIOPT Version :9

• Sequence 1: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_002933223.2
• Gene: plekhm1 / 100491541
• XenbaseID: XB-GENE-6033729
• Length: 1061
• Species: Xenopus tropicalis
• Alignment Length: 1067
• Identity: 233/1067 - (21%)
• Similarity: 359/1067 - (33%)
• Gaps: 392/1067 - (36%)

  Fly    23 LINTLNENAREIEFEVKQK-------SLEVLGV------------CEQTSALCTTLEALFLHGLK 68
            |.:..:|||:|.: ||||:       ||..|.:            .:..:|||..|||:|:||||
 Frog     2 LSSLTSENAQEPK-EVKQRITKKLATSLRALQIRYVTTDDVVTSDDDDANALCVALEAVFIHGLK 65

  Fly    69 DSFLSATFNVIAGDVERR-----------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRA 122
            ..|:.|       ..::|           |:|::||......|:.||.:::.:|.|.::.|:||:
 Frog    66 PKFIKA-------QTDKRNRRYKGRHVPLPQPAYWALLKAVTHRNVITELERVSYINTDVGRCRS 123

  Fly   123 WVRQSLNESVFSSYLNNMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSL 187
            |:|.:||:.:...|..::::..|.|::||:..||:.|:|..:.....::.. |.:.|.|...||:
 Frog   124 WLRLALNDCLMECYFISLQREKSWLTEYYQPFALLLDAEDCDVVLSYLQGF-ASLTFSLSYKSSI 187

  Fly   188 LNHWPDYSLQLSDLW-------------TPALKS----CPISSGVDVASSLGSDIIA-IPTPQPL 234
            ||.|....|.|:.||             |...||    ...||..|..|||.|:... :.:|..|
 Frog   188 LNEWTATPLSLAGLWLDDSDRFTNGQYETHRRKSLDSVSQSSSSDDTNSSLLSESKGKMDSPLNL 252

  Fly   235 QTNEL---FSESISNSPF--GRNSNFGVPELSQRENLDLLIQKFDEMDVINEEQTGGD------- 287
            .||..   ||.|:|:...  .|.::.|:...|:..:.|....:.:|.|..:.|::..|
 Frog   253 DTNSASLQFSSSLSSEGLLHNRTTSSGIHSGSENSSCDADSAEMEESDKSHAEESEFDVSLLSGR 317

  Fly   288 -----------KAETNETAEQEAPSGSKTRSR--KKSNRQMDSSSFADL-----DLEAPS----- 329
                       ..|.....|:..|.|.|.:..  .|.....:.:..|||     .::|||
 Frog   318 NSPTVFLPTPHSGEVVSQPEKTTPQGIKCQGELDVKETPLTECAIKADLITPPASIKAPSSSLCT 382

  Fly   330 --------------------------------LLPQG---SNSLSNLMQTSWSGD---------- 349
                                            ..|:.   .|.:..|.|.:...|
 Frog   383 RSDKPSAPPEQPNPVICQNPTTEESHRGPTFKTSPENDAHENQIDKLPQAAQINDQADGCIYDKG 447

  Fly   350 ----LEATPTSPTE----------------------ELTGSRF------FQR-SVSVSSSVSLRS 381
                |||.|.|...                      ||..||.      ||| .:|:.:..:|.:
 Frog   448 CSQALEAPPASLASVTSVSKDKSGVCLSVPEHPIVAELPKSRSWISEDDFQRPELSLPTESTLSA 512

  Fly   382 PT--------------------------------------------------------------- 383
            |:
 Frog   513 PSIPSQPPSSEISDLSQVNKAFNVVHRRQIGLSNPFRGLLMMGDLERRALGMYKSFYCELTPIEF 577

  Fly   384 ------TDR-CSYNALLRKHES------------------------NRESGAGW----------- 406
                  .|| |..|..|.:.||                        :|:....|
 Frog   578 RMFLKGEDRVCLENCTLIRCESVGPVQSDGRFDLNFPAKRFHLRAPSRDEAQDWVDRIREALQKC 642

  Fly   407 ----SEIWEKFR-----ASASNLNVAQPQRDTDPPIS---------------------------- 434
                .:.||..:     .:.....:..|||....|:.
 Frog   643 RPQKDDTWEVLQFPDPPKTGQESPLLSPQRSPSSPVGSIKTESFDWVCPLKLEPDALKESVLYMK 707

  Fly   435 --------------------------------------EDLSDLQSLDTNSEFELLTSEFDM--- 458
                                                  .|:....||.:.|.|:|:||:..:
 Frog   708 MDKKWTRCIFSLTERELRCYLAKNSEKVLHNIFGIEMVRDILPDASLGSPSCFKLVTSKGSLQLQ 772

  Fly   459 ------------------VELQQMVAQLCQLA---------------------REPGLDAQGFLC 484
                              :||...:|.|...|                     .|.|||:|.|.|
 Frog   773 AESSSEAKHWREMVRDVYLELADELALLAGTASFPIKSHIRGHALFQYLLYIPSEKGLDSQNFKC 837

  Fly   485 KSCQHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSH 549
            .:|...:|..:...:.||:|..|||..|...|..:||:|:::|||..:.:||:.|..||....:.
 Frog   838 AACHKQIGFQFGKAKHCAYSALYYCEWCHQDEGSVIPSRMVHNWDLTEQAVSRPALKFLNMVLNE 902

  Fly   550 PFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIHLYS 614
            |.:::..:|..:|..|..|..:...|.:|..:..||.||...:.:.|......|.||.:..|.||
 Frog   903 PIINVPSVNSGLYQHSHTMHNISHSREKLRLLAEYLQTCRSGAFQELSKSLDNRTYLLDCAHTYS 967

  Fly   615 IADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGA 679
            :.|...|..|.....|..|..|...||..|.||..|||||:||....::|||...||.||..|.:
 Frog   968 VQDFRQIANGEFELFLGAAVDLATKHVYDCDLCSQKGFICQICNQDEIIYPFQFETTTRCGDCKS 1032

  Fly   680 VFHAECLNEKQPCPKCERIRKREDQGL 706
            |||..|..|.:.||:|.|.:|.:.||:
 Frog  1033 VFHIPCKAEVKQCPRCLRRKKYQVQGV 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	42/141 (30%)
		zf-RING_9	500..700	CDD:290612	72/199 (36%)
plekhm1	XP_002933223.2	RUN	51..183	CDD:397055	42/139 (30%)
		PH_PLEKHM1	523..644	CDD:241475	9/120 (8%)
		PH	699..789	CDD:214574	8/89 (9%)
		zf-RING_9	853..1050	CDD:404739	71/196 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3295
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2811
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48070
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5810
SonicParanoid	1	1.000	-	-		X6907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.000