Protein Alignment KCND3 and Kcnd3

DIOPT Version :10

• Sequence 1: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_001257891.1
• Gene: Kcnd3 / 65195
• RGDID: 68394
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 655
• Identity: 652/655 - (99%)
• Similarity: 653/655 - (99%)
• Gaps: 0/655 - (0%)

Human     1 MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTL 65

Human    66 LGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGD 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 LGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGD 130

Human   131 CCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAV 195
            |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   131 CCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAV 195

Human   196 SVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMS 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 SVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMS 260

Human   261 IIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 IIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 325

Human   326 FSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 FSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 390

Human   391 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALE 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALE 455

Human   456 LTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNC 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 LTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNC 520

Human   521 MESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPS 585
            |||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 MESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPS 585

Human   586 LTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVV 650
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
  Rat   586 LTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVV 650

Human   651 KVSAL 655
            |||||
  Rat   651 KVSAL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726	136/136 (100%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21		14/14 (100%)
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78		7/7 (100%)
		Ion_trans	186..412	CDD:459842	225/225 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		4/4 (100%)
		DUF3399	468..563	CDD:463381	93/94 (99%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		16/16 (100%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		14/14 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		38/39 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		38/39 (97%)
Kcnd3	NP_001257891.1	BTB_POZ_KCND3	6..143	CDD:349726	136/136 (100%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	6..21		14/14 (100%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	70..78		7/7 (100%)
		Ion_trans	186..412	CDD:459842	225/225 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		4/4 (100%)
		DUF3399	468..563	CDD:463381	93/94 (99%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17	470..487		16/16 (100%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489		14/14 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..565		40/41 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..647		30/30 (100%)