DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND3 and Shawl

DIOPT Version :10

Sequence 1:NP_004971.2 Gene:KCND3 / 3752 HGNCID:6239 Length:655 Species:Homo sapiens
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:757 Identity:200/757 - (26%)
Similarity:314/757 - (41%) Gaps:200/757 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    42 IVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHY 105
            |:|||||.|::|::.||::.|.|.|.. ||....::....||||||.|.||..:||:||||||||
  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGKLHY 71

Human   106 PRYECISAYDDELAFYGILPEIIGDCCYEEYK-DRKRENAERLMDDNDSENNQESMPSLS----- 164
            |...|...:::||.|:|:....:..||:..|. .|..:|...::|..|.||.:.:...::     
  Fly    72 PTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLFGF 136

Human   165 --------------FRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------- 206
                          .:..:|..|:.|.:||.|.:...::.|||.||||:..::|.|         
  Fly   137 EEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSG 201

Human   207 --------CGTVPGSKELPCGE--------RYSV------------------------------- 224
                    .|..|...: |.||        ::|:                               
  Fly   202 AHDAHGPGAGGPPHGHD-PMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQAT 265

Human   225 --------------------------------------------------AFFCLDTACVMIFTV 239
                                                              |||.::..|.:.|.:
  Fly   266 PIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFI 330

Human   240 EYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHS 304
            |.::||..:|:.::||:|.::|||..|.:.:|.. ||....:.:|......:.|:.|:||.:|||
  Fly   331 EVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD-VMQRMGEYTGLLEAFSIVRIMRLFKLTRHS 394

Human   305 QGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTT 367
            .|||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  .:..::|.|||...|:.||||||
  Fly   395 PGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTT 459

Human   368 LGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRV 432
            :||||:.|||..|...|::|:|:|||.|||||||||||||..|...| |..:..:|:.|:..:..
  Fly   460 VGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ-ARSKLPKKRRRVLPVEQ 523

Human   433 AKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPL 497
            .:         .||.            |...|.|:|.::.::          ..||.. ||...:
  Fly   524 PR---------RKRE------------PTAPHRGRTNAIKQT----------PPTGPG-LVAGGV 556

Human   498 LSVRT------STIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPG-LTTTCCSRRSKKTT 555
            :.|..      .....|......||:.....:.:..........:..||. .|||..:....:..
  Fly   557 VPVGAGGPGLGGHAVGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEAD 621

Human   556 HLPNSNLPATRLRSMQELST-----------IHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQ 609
            ..|.|.| ..::..:|...|           .|..|....::|:|.|         |..:..::.
  Fly   622 PTPMSAL-TYQVPMLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSAS---------LTGSAASAA 676

Human   610 ITTAIISIPTPPAL-------TPEGES-RPPPASPGPNTNIP 643
            :.||..:.|..|:.       .|..:| :|..|:.|.:..:|
  Fly   677 VATAAAAAPAGPSFISSDYLSVPAVQSLQPRAATTGHDFMLP 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND3NP_004971.2 BTB_POZ_KCND3 6..143 CDD:349726 44/102 (43%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220 6..21
Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064 70..78 1/7 (14%)
Ion_trans 186..412 CDD:459842 101/333 (30%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 3/4 (75%)
DUF3399 468..563 CDD:463381 16/101 (16%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220 470..487 0/16 (0%)
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 472..487 0/14 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..565 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655 8/37 (22%)
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 45/107 (42%)
Ion_trans 307..506 CDD:459842 86/199 (43%)
Blue background indicates that the domain is not in the aligned region.

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