Protein Alignment KCND3 and Task6

DIOPT Version :10

• Sequence 1: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 90/464 - (19%)
• Similarity: 170/464 - (36%)
• Gaps: 140/464 - (30%)

Human   127 IIGDCCYEEYK-DRKRENAERLMDDND--------SENNQESMPSLSFRQTMWRAFENPHTSTLA 182
            ::|...::..: :.::...|.|.|..|        |:.:.:.|.::..:....:|.:.
  Fly    20 LVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDFKVMETVVLKSESHKAGQQ------- 77

Human   183 LVFYYVTGFFIAVSVITNV--VETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRL 245
              :.:...|:.|.:|:|.:  ..:.| .||.|.                      :||:.|
  Fly    78 --WKFTGAFYYATTVLTTIGYGHSTP-STVGGK----------------------LFTMCY---- 113

Human   246 FAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFR-IFKFSRHSQGLRI 309
                                ||:...:||||..:       :..||.|:.. :.|..|.|...:
  Fly   114 --------------------AIVGIPLGLVMFQS-------IGERVNRLSSYVIKAVRSSLRCK- 150

Human   310 LGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSA-SKFT--SIPASFWYTIVTMTTLGYG 371
                 ::.|||:..:....|::.:..|       .|::| |||.  |...|.:|..:|:||:|:|
  Fly   151 -----RTVASEVDLICVVTTLSSLTIA-------GGAAAFSKFEGWSYFDSVYYCFITLTTIGFG 203

Human   372 DMV-----------PKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKA 425
            |||           |:.:   :|..|..|.|:.::|..:.::|..|..:..:::|.|:.:|.:..
  Fly   204 DMVALQRDNALNRKPEYV---MFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRDEAQAMQAL 265

Human   426 RLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPE-----------EEHMGKTTSL-----IES 474
            ::|........:||..:.|...|...::|..:.|..           ..|. |:::|     .|:
  Fly   266 QVAVKLEGDVITSNGSILSGYEGHDGQSLNGSNTSSMCSCHCICLNGNRHK-KSSNLEKNNDAEN 329

Human   475 QHH------HLLHCLEKTT---GLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPS 530
            |:.      |:.|.|.:..   .|:|..|...|         |...|....:.:.|...|.:...
  Fly   330 QYKLRQSPTHIRHLLPEVVPMQDLNYDYDTQSL---------HTLADRGTMDSSYMGVDMADMGD 385

Human   531 TRSPSLSSH 539
            |.|..|..|
  Fly   386 TGSMELRPH 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726	1/16 (6%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78
		Ion_trans	186..412	CDD:459842	52/242 (21%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		2/4 (50%)
		DUF3399	468..563	CDD:463381	18/86 (21%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		6/27 (22%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		5/15 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	17/107 (16%)
		Ion_trans_2	165..243	CDD:462301	24/87 (28%)