DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCND3 and Shal

DIOPT Version :10

Sequence 1:NP_004971.2 Gene:KCND3 / 3752 HGNCID:6239 Length:655 Species:Homo sapiens
Sequence 2:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster


Alignment Length:608 Identity:379/608 - (62%)
Similarity:454/608 - (74%) Gaps:56/608 - (9%)


- Green bases have known domain annotations that are detailed below.


Human     3 AGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQ--DELIVLNVSGRRFQTWRTTLERYPDTL 65
            |.|||||||||||||||:|:|..|:|..|..|::|:  ||.:::|||||||:|||.|||:|||||
  Fly     2 ASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTL 66

Human    66 LGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGD 130
            |||.|:|||::||.|||||||||::||.:||:|||||||||::||:::||:||||:||:|::|||
  Fly    67 LGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGD 131

Human   131 CCYEEYKDRKRENAERLMDDNDSENNQESMPSL-SFRQTMWRAFENPHTSTLALVFYYVTGFFIA 194
            ||||:|:|||||||||||||..|||..:::..| :.||.||||||||||||.|||||||||||||
  Fly   132 CCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIA 196

Human   195 VSVITNVVETVPCGTVPG-SKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSV 258
            |||:.|||||||||..|| :..|||||||.:.|||||||||||||.||||||||||.|.:|:|||
  Fly   197 VSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSV 261

Human   259 MSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 323
            ||||||||||||||||.:|:|:|||||||||||||||||||||||||||||||||||||||||||
  Fly   262 MSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 326

Human   324 LLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICS 388
            |:|||.|||||||||||||||..:.:.||||||:||||||||||||||||||:||||||.|.:||
  Fly   327 LVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCS 391

Human   389 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEA 453
            |||||||||||||||||||||||||||||||:||:||||||||:||..|..|::..|:......|
  Fly   392 LSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWA 456

Human   454 LELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQ 518
            .:.:|...:::. :...:.|.||||||.||||||                        |.:..|.
  Fly   457 AQESGIELDDNY-RDEDIFELQHHHLLRCLEKTT------------------------DREFVEL 496

Human   519 NCMESSMQNYPSTRSP------SLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIH 577
            ....:.....|.:.||      |.:|..||..:||.|...:            |.::.       
  Fly   497 EIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQ------------RYQAC------- 542

Human   578 IQGSEQPSLTTSRSSLNLKADDG 600
              |...|:.:.:::|.|.:..||
  Fly   543 --GKYMPAASNAQNSQNNQPMDG 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCND3NP_004971.2 BTB_POZ_KCND3 6..143 CDD:349726 95/138 (69%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220 6..21 14/14 (100%)
Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064 70..78 4/7 (57%)
Ion_trans 186..412 CDD:459842 193/226 (85%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 4/4 (100%)
DUF3399 468..563 CDD:463381 25/100 (25%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220 470..487 11/16 (69%)
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 472..487 11/14 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..565 10/45 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 94/137 (69%)
Ion_trans 188..415 CDD:459842 193/226 (85%)
DUF3399 471..535 CDD:463381 25/87 (29%)
Blue background indicates that the domain is not in the aligned region.

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