Protein Alignment KCND3 and kcnd3

DIOPT Version :10

• Sequence 1: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Sequence 2: XP_005167059.1
• Gene: kcnd3 / 327415
• ZFINID: ZDB-GENE-030131-5626
• Length: 650
• Species: Danio rerio
• Alignment Length: 675
• Identity: 500/675 - (74%)
• Similarity: 573/675 - (84%)
• Gaps: 45/675 - (6%)

Human     1 MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTL 65
            ||||||||||||||||||||||||.|||:||::|||||||||:||||||||||||.||:||||||
Zfish     1 MAAGVAAWLPFARAAAIGWMPVANLPMPVAPSNKNKRQDELIILNVSGRRFQTWRNTLDRYPDTL 65

Human    66 LGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGD 130
            |||:||||||||:|:||||||||:|||.:|||||||||||||||||||||:||||:||:||||.|
Zfish    66 LGSSEKEFFFNEETREYFFDRDPDVFRSILNFYRTGKLHYPRYECISAYDEELAFFGIIPEIISD 130

Human   131 CCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAV 195
            |||||||||||||.||||||.: :|....:|:::||:|||||||||||||:|||||||||||||:
Zfish   131 CCYEEYKDRKRENTERLMDDLE-DNKDSKLPNMTFRETMWRAFENPHTSTMALVFYYVTGFFIAL 194

Human   196 SVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMS 260
            |||||||||||||.:|..:::||||||:.||||:|||||||||||||:|||||||||||:|||||
Zfish   195 SVITNVVETVPCGYMPNQRDVPCGERYTEAFFCMDTACVMIFTVEYLMRLFAAPSRYRFMRSVMS 259

Human   261 IIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 325
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   260 IIDVVAILPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLL 324

Human   326 FSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 390
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Zfish   325 FSLTMAIIIFATVMFYAEKGSSSSKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLS 389

Human   391 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQK--KARLARIRVAKTGSSNAYLHSKRNGLLNEA 453
            |||||||||||||||||||||||||||||:|||  ||||||:|::|:|||.|:||||||| ||::
Zfish   390 GVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKVQKARLARMRISKSGSSTAFLHSKRNG-LNQS 453

Human   454 LELTGTP-------------EEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTI 505
            ||||..|             |::.:.|||||:|||||||||||||||
Zfish   454 LELTQLPYYKMKLSPQGSLEEDQQLKKTTSLLESQHHHLLHCLEKTT------------------ 500

Human   506 KNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSM 570
             ||||:||:::||..:::::||:|| :||||||..|:|.||||||.||.....|:....:...::
Zfish   501 -NHEFVDERLYEQGYLQTALQNFPS-QSPSLSSEEGITGTCCSRRPKKNIQPLNATHTHSHTHNL 563

Human   571 QELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTS-QITTAIISIPTPPA----LTPEGESR 630
            ||||.:|||..||..|.||||||||.:|:....|||:| .:|||||||||||:    .:|:..|.
Zfish   564 QELSALHIQCGEQQPLNTSRSSLNLMSDESGSLNCKSSGLVTTAIISIPTPPSNNSRASPDAPSP 628

Human   631 PPPASPGPNTNIPSIASNVVKVSAL 655
            |.|.:| |..| || :::|||:|||
Zfish   629 PNPEAP-PLLN-PS-STDVVKISAL 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726	119/136 (88%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21		14/14 (100%)
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78		7/7 (100%)
		Ion_trans	186..412	CDD:459842	210/225 (93%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		4/4 (100%)
		DUF3399	468..563	CDD:463381	48/94 (51%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		15/16 (94%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		13/14 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		21/39 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		20/43 (47%)
kcnd3	XP_005167059.1	BTB_POZ_KCND3	6..143	CDD:349726	119/136 (88%)
		Ion_trans	181..411	CDD:459842	214/229 (93%)
		DUF3399	481..556	CDD:463381	48/94 (51%)