Protein Alignment KCND3 and Ork1

DIOPT Version :10

• Sequence 1: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 68/325 - (20%)
• Similarity: 103/325 - (31%)
• Gaps: 113/325 - (34%)

Human   366 TTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR---------- 420
            :.||.|....|..|||                      .....||.|||....||
  Fly   651 SALGGGAYQRKAAAGK----------------------RRRESIYTQNQAPSARRGSMYPPTAHA 693

Human   421 -AQKKARLARIRVAKTGSSNAYLHSKRNGLL----NEALELTGTPEEEHMGKTTSLIESQHHHLL 480
             ||.:.|...:..:.:||:.....:.|.|.|    ..|..||..|....:...||..:      :
  Fly   694 LAQMQMRRGSLATSGSGSAAMAAVAARRGSLFPATASASSLTSAPRRSSIFSVTSEKD------M 752

Human   481 HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTT 545
            :.||:||     :.|.:.::  ..:..|..:|||.             .:..:...:...|:
  Fly   753 NVLEQTT-----IADLIRAL--EVVHTHAVLDEQQ-------------QAAAAGGAAGGGGI--- 794

Human   546 CCSRRSKKTTHLPNSNLPATRLRSMQEL----STIHIQGSEQPSLTTSRSSLNLKADDGLRPN-- 604
              ||.|:|...:.|:.|...:|..:..|    .|..:|.:....|...||::     .|:.|.
  Fly   795 --SRGSRKQRKMGNAGLEPPQLPPILSLFAGDQTRTLQAAAANRLYARRSTI-----VGISPTGG 852

Human   605 ---------------------CKTSQITTAIISIPT------------PPAL-TPEGESRPPPAS 635
                                 ...||||....:.||            |.|| .|.|::.||.||
  Fly   853 AATAPAARSLLEPPPSYTERAANQSQITAGPSNAPTVQSKFRRRFSVRPTALQIPPGQAPPPGAS 917

Human   636  635
              Fly   918  917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78
		Ion_trans	186..412	CDD:459842	9/45 (20%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		2/4 (50%)
		DUF3399	468..563	CDD:463381	17/94 (18%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		3/16 (19%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		2/14 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		7/39 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		11/34 (32%)
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301
		Ion_trans_2	185..266	CDD:462301