Protein Alignment CG13502 and Tmtc1

DIOPT Version :10

• Sequence 1: NP_611637.1
• Gene: CG13502 / 37518
• FlyBaseID: FBgn0034692
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_945318.2
• Gene: Tmtc1 / 387314
• MGIID: 3039590
• Length: 942
• Species: Mus musculus
• Alignment Length: 329
• Identity: 70/329 - (21%)
• Similarity: 126/329 - (38%)
• Gaps: 88/329 - (26%)

  Fly    89 GNRIEAELRAARKKIEEQIAKKKKPKENFVDFYTDKDRAAAVSAGAFDIKQSLQIKQKQDRNEAL 153
            ||.::::     :|.||.|...|:..:...||      |.|.|:.|..:.:..:.|:.:|..:|.
Mouse   615 GNLLKSQ-----EKTEEAIMLLKESIKYGPDF------ADAYSSLASLLAEQERFKEAEDIYQAG 668

  Fly   154 L--IPDEADISSVIALGLKEIKNANPENAIHFFCKALELNSTDINALISRSKCYLLLGEASK--- 213
            :  .||.:|:.:..|:.|  :.:..||.|:..:.:|::|:.:...|:::..:.|..|||.||
Mouse   669 IKNCPDSSDLHNNYAVFL--VDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEE 731

  Fly   214 ----ALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRARPELALFRLGVQ---- 270
                ||:.|.||  |..:.:.|:|      |..|:.:::|..:...:..:|.....||.:.
Mouse   732 WYRRALKVARTA--EVLSPLGALY------YNTGRHKEALEVYREAVSLQPSQRELRLALAQVLA 788

  Fly   271 ----------------------------------------KTQEAIENTIGSKPGPPGPTASV-- 293
                                                    |..||||..:..||..|...:.:
Mouse   789 VMGQTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISELFF 853

  Fly   294 PKSGKSRKSG--EDTPKSQAAGATGTSARTRQKPSRAD--LERRNARKLLGELCVDKEYLEKLL- 353
            .|..:.|:..  :...:|..|..|       ..|.:|.  :.....|.:.|.....:.|.|:.|
Mouse   854 TKGNQLREQNLLDKAFESYEAAVT-------LDPDQAQAWMNMGGIRHIQGSYVSARAYYERALK 911

  Fly   354 LHPD 357
            |.||
Mouse   912 LVPD 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13502	NP_611637.1	TPR	150..>277	CDD:440225	35/179 (20%)
		TPR repeat	165..189	CDD:276809	6/23 (26%)
		TPR repeat	194..224	CDD:276809	12/36 (33%)
		TPR repeat	229..257	CDD:276809	5/27 (19%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..285
		TMTC_DUF1736	351..425	CDD:462468
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	543..576
		TPR repeat	543..571	CDD:276809
		LapB	547..798	CDD:442196	47/203 (23%)
		TPR repeat	576..603	CDD:276809
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	577..607
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	608..641		7/30 (23%)
		TPR repeat	608..636	CDD:276809	7/25 (28%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	642..675		8/32 (25%)
		TPR repeat	642..670	CDD:276809	7/27 (26%)
		TPR repeat	675..705	CDD:276809	7/31 (23%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	676..709		8/34 (24%)
		LapB	683..938	CDD:442196	51/250 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	710..742		10/31 (32%)
		TPR repeat	710..738	CDD:276809	8/27 (30%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	743..776		8/40 (20%)
		TPR repeat	743..771	CDD:276809	7/35 (20%)
		TPR repeat	776..806	CDD:276809	2/29 (7%)
		TPR 8. /evidence=ECO:0000255	777..810		2/32 (6%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	811..844		7/32 (22%)
		TPR repeat	812..839	CDD:276809	5/26 (19%)
		TPR repeat	844..878	CDD:276809	6/40 (15%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	849..882		6/39 (15%)
		TPR 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	883..916		9/33 (27%)
		TPR repeat	883..911	CDD:276809	5/27 (19%)