DRSC/TRiP Functional Genomics Resources

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Protein Alignment Synj and SYNJ2

DIOPT Version :9

Sequence 1:NP_001246454.1 Gene:Synj / 37517 FlyBaseID:FBgn0034691 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_003889.1 Gene:SYNJ2 / 8871 HGNCID:11504 Length:1496 Species:Homo sapiens


Alignment Length:1381 Identity:542/1381 - (39%)
Similarity:757/1381 - (54%) Gaps:212/1381 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65
            ||:||.:|:|.:..|....|||||.|.:.|.:|||:..||.|..:|.:||:.||.|:.|||||||
Human     1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLG 65

  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130
            .|:|.:|.:::.||||||||.|:|:|.|.||::||.|.|..||..|..|:::..::|:|:||.||
Human    66 ELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFY 130

  Fly   131 FAHTNASASASGASSYRFDITLCAQRR-QQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194
            |:..|..:        |||:|:..|:: ..:.|..|.||||:::|:.|.:..:.|..|||:.:||
Human   131 FSWPNDGS--------RFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICG 187

  Fly   195 SVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTR 259
            .|.:||||...|||:|.::||:||||.||||:.||.||:|:|:|||||||:||:|..|:|:||.|
Human   188 VVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIR 252

  Fly   260 GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAM 324
            |||||||||||:|||||.::|.||.|.:|.||||||.:::::||.|.|||||     ||:.||.:
Human   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLL-----GSRGGEEV 312

  Fly   325 LSNEFQRHHGMSAHK-DVPHVVFDYHQECRGGNFSAL-AKLKERIVACGANYGVFHASNGQVLRE 387
            |:..|::....|.|. |.|.:.||:||..:||....| ..|:.::.....::.||........|.
Human   313 LNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRF 377

  Fly   388 QFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKI 452
            |.|.:|.||||||||||.||:::.|:.|.:||:.|.:..| ..:.||.|.|:.||..||:.:||:
Human   378 QKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSK-PIVDRFVESFKAMWSLNGHSLSKV 441

  Fly   453 YAGTGAIQGGS---KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514
            :.|:.|::|.:   ||.|||||.:||||:|..|..|||||.:||||.....|:||:..:||.|..
Human   442 FTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTA 506

  Fly   515 LHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDS-LADWLLDCHALARSKAL 578
            |.....:|:.:.:|.:|:...:..|:|:||:||||||.|||.|.:.: |.|||||...|:.:   
Human   507 LLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGA--- 568

  Fly   579 VDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQL 643
                ..|::...|.||:|:||||:|:|:|.||:.|||.|.|:|.|:|||.|||.:.|:|||..||
Human   569 ----TDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQL 629

  Fly   644 VGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVA 708
            |||||||::||.|.|.|||||||.||||:||..|||||..|||..|.||.||:|:|..||||||.
Human   630 VGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVK 694

  Fly   709 ERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKE 773
            |||.||.|||:||.|||||.:.|||:||||||||||||:..:|:...|:..|...:||||||:.:
Human   695 ERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQ 759

  Fly   774 QEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------ALAE 828
            :.:|.:|.:|.||.|.|.||||||:.|..||||:|.|.|||||||||.|:|          .|.:
Human   760 KSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLD 824

  Fly   829 GDF-----AASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPD 888
            .|.     ....|:||.|.:|||:||:.||||||:||::.|:.|:|...|..||::|....||.|
Human   825 SDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLD 889

  Fly   889 STIVVHVLESSATGDEDGPTI-----YDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESA 948
            :|:||::         ..||:     :.|::.:.|:..|...|.:.|||..:..|.|||.|..||
Human   890 ATVVVNL---------QSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSA 945

  Fly   949 LNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQA--------- 1004
            |:......::|.|..:.:..|:|||...:..||.....:..|:  :|..::.||:.         
Human   946 LSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPV--SPTANSCLLEENFDFTSLDY 1008

  Fly  1005 -------------ITPELPQR---------------PKQPPTRPPARPPMPMSPKNSPRHLPHVG 1041
                         :..|..|.               |......||::.|.....|..|.:.....
Human  1009 ESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD 1073

  Fly  1042 VISI--------------------VPKPAKPPMPPQPQSQP------------------------ 1062
            ::.:                    ||...:||.|||....|                        
Human  1074 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSI 1138

  Fly  1063 -----LIP-SPLQPQVA------PPRPPAMDTTPSSKSQ---------------------SPTEL 1094
                 |:| :|.||..|      |.....:.||.:.:::                     :|.:|
Human  1139 LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL 1203

  Fly  1095 VSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPT-RQVGSPKDPI----------- 1147
            .::|....:.|...|..|   ..||..||: ...:...:..|| |:.|.|..|.           
Human  1204 EASSEPEPTPGAAKPETP---QAPPLLPRR-PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264

  Fly  1148 --PSDTAYETASNIYEEIQEDVPAPR------------HPPPAG--PPPVIGAPMGPP---PPLP 1193
              |.:|:.|....:.......||.||            |..||.  .||..||.:.||   |||.
Human  1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLV 1329

  Fly  1194 NRRGPPPIPNRSGNAP 1209
                |...|.|..:||
Human  1330 ----PKVPPRRKKSAP 1341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynjNP_001246454.1 Syja_N 61..353 CDD:280532 146/293 (50%)
INPP5c_Synj 538..863 CDD:197323 188/340 (55%)
DUF1866 862..1008 CDD:286093 42/172 (24%)
SYNJ2NP_003889.1 Syja_N 61..342 CDD:280532 146/293 (50%)
EEP 530..861 CDD:294334 186/337 (55%)
DUF1866 872..1008 CDD:286093 39/146 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1073 7/45 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1085..1166 15/80 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1405 40/160 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1427..1473
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146120
Domainoid 1 1.000 86 1.000 Domainoid score I8104
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D359616at2759
OrthoFinder 1 1.000 - - FOG0002172
OrthoInspector 1 1.000 - - otm41819
orthoMCL 1 0.900 - - OOG6_101787
Panther 1 1.100 - - O PTHR11200
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1445
SonicParanoid 1 1.000 - - X1883
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.740

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