DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Synj and SYNJ1

DIOPT Version :9

Sequence 1:NP_001246454.1 Gene:Synj / 37517 FlyBaseID:FBgn0034691 Length:1218 Species:Drosophila melanogaster
Sequence 2:NP_003886.3 Gene:SYNJ1 / 8867 HGNCID:11503 Length:1612 Species:Homo sapiens


Alignment Length:1349 Identity:627/1349 - (46%)
Similarity:832/1349 - (61%) Gaps:179/1349 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65
            ||.||..|:..| :.|.|.|:::|.|:|.:.::|||.|||:|:..|.:.|:..|:||.||||.||
Human    40 MAFSKGFRIYHK-LDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLG 103

  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130
            .|:||.|::.:.:|||||||:|:|||.:.|:||:|.|.|:||:..:.:||:||||||:||||.||
Human   104 VLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFY 168

  Fly   131 FAHTNASASASGASSYRFDITLCAQRRQQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCGS 195
            ||.     ||||.|   .|::|.|.|..|.|.||||||||:.:|:||..:|::|..|||:.|||.
Human   169 FAW-----SASGIS---LDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGG 225

  Fly   196 VEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRG 260
            ||:||:|...|||:|.:||||||||||||||||||||:|:||||||||||:|:|..|:|::|.||
Human   226 VEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRG 290

  Fly   261 SVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAML 325
            ||||||||||:|||||:|::|||||.:|.|||||...::..||.|.:||||     ||||||.||
Human   291 SVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLL-----GSKEGEHML 350

  Fly   326 SNEFQRHHGMSAH-KDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHASNGQVLREQF 389
            |..||.|...|.| .|:..|.|||||..:||....|..:.:..|....:||.|:.:..:|.|.|.
Human   351 SKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQS 415

  Fly   390 GVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYA 454
            |.|||||||||||||.||.:|||:.|..|||||.:..|.|.::||:|:||.||..||:.:|||||
Human   416 GTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYA 480

  Fly   455 GTGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLH--- 516
            ||||::|.:||.|||||..||||||..|:||||||||||:|:||:|:|||:||.||.:..|.   
Human   481 GTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSE 545

  Fly   517 -----APTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKD-SLADWLLDCHALARS 575
                 |.:.||:.:|:.:.:|.:|:..||.|||:||||||.||||.||: :|.|||||...||..
Human   546 QTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGI 610

  Fly   576 KALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTY 640
            :...|..:      .|.||:||||||:|:|||.||::|||.|.||||.||||||||||.||||..
Human   611 QEFQDKRS------KPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLAS 669

  Fly   641 QQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQS 705
            :|||||||:::|||:|||.|||||:|.||||:|||||||||.|||.:.|.||:||||:|||||||
Human   670 EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQS 734

  Fly   706 QVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQL 770
            ||.|||.|:.||.|||:|||||.|.|||:||||||||||||:..:|:||.:|..:..:::..|||
Human   735 QVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQL 799

  Fly   771 RKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------A 825
            ..::.||.||..||||::||.|||||||||||||||||.|.|||||||||||||          .
Human   800 INQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLD 864

  Fly   826 LAEGDFAASA-----WNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLG 885
            |....|...:     |.||.|:||||:|||.||||||:|:||.:|.|::.:.|:.::::||...|
Human   865 LLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQG 929

  Fly   886 PPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALN 950
            |||.|::|.:..|....:     .:|:.::..|:.:.:..|||.|:|:|||.|||||.:|.||||
Human   930 PPDGTVLVSIKSSLPENN-----FFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALN 989

  Fly   951 ASSKKSIQVCGLDLILELKSKDWQHLVDSEIEL---------CTTNTI----------------- 989
            ..|....::....:.:.|||.||...::.|:.|         .|::|:                 
Human   990 VLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDV 1054

  Fly   990 --------------------------PLCA---NPVEHAQLLQAITPELPQRPKQPPTRPPARPP 1025
                                      |..:   :|.:...:.:...|.||.||.:.|:|.|..|.
Human  1055 DDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1119

  Fly  1026 MPMSPKNSPRHLPHVGVISIVPK--PAKP-----PMPPQPQSQPLIPSPLQPQVAPPRPPAMDTT 1083
            ...||.::....|       :|:  ||:|     |.||:|.:.|..|:|  ||..||...|....
Human  1120 AQSSPIDAQPATP-------LPQKDPAQPLEPKRPPPPRPVAPPTRPAP--PQRPPPPSGARSPA 1175

  Fly  1084 PSSKS-------QSP------TELVSASSST--SSSGKTSPTAPAVLSGP---------PT-PPR 1123
            |:.|.       .||      .|...:..:|  .:.|::.|:..|.|:||         || |||
Human  1176 PTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR 1240

  Fly  1124 -------QMQSKQATPVSTPTRQVGSPK---------DPIPSDTAYETASNIYEEIQEDVPAPRH 1172
                   |..::.:....||..|..:.:         :|:....|:...|::             
Human  1241 AGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL------------- 1292

  Fly  1173 PPPA----GPPPVIGAPMGPPPPLPNRRGPPPIPNRSGNAPPLPTRPAN 1217
            ||||    .|...:.|||....|.||...||..|.||.::..||:..::
Human  1293 PPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASS 1341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SynjNP_001246454.1 Syja_N 61..353 CDD:280532 175/292 (60%)
INPP5c_Synj 538..863 CDD:197323 213/340 (63%)
DUF1866 862..1008 CDD:286093 45/200 (23%)
SYNJ1NP_003886.3 Syja_N 99..379 CDD:280532 175/292 (60%)
INPP5c_Synj1 572..907 CDD:197332 213/340 (63%)
DUF1866 906..1047 CDD:286093 43/145 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146097
Domainoid 1 1.000 409 1.000 Domainoid score I694
eggNOG 1 0.900 - - E1_COG5411
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H48252
Inparanoid 1 1.050 1110 1.000 Inparanoid score I229
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48338
OrthoDB 1 1.010 - - D359616at2759
OrthoFinder 1 1.000 - - FOG0002172
OrthoInspector 1 1.000 - - otm41819
orthoMCL 1 0.900 - - OOG6_101787
Panther 1 1.100 - - LDO PTHR11200
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1445
SonicParanoid 1 1.000 - - X1883
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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