DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and INP51

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_012264.3	Gene:	INP51 / 854815	SGDID:	S000001264	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	950	Identity:	245/950 - (25%)
Similarity:	414/950 - (43%)	Gaps:	183/950 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LFESHAVALLTQQETDVIR-KQYTKV--CDAYGCLGALQLNAGESTVLFLVLVTGCVSMG----K 90
            |.::.:|.:.:..:||:.. ..|.:|  |...|.||.:.||..    :::.:::|..::|    |
Yeast    39 LSKTPSVTIKSYPDTDLSSDSNYLEVKSCIFNGLLGLVCLNGD----IYVAVISGVQNVGFPRWK 99

  Fly    91 IGDIE------IFRITQTTFVSLQN----------AAPNEDKI------SEVRKLLNSGTFYFAH 133
            :.|.:      |:::....|.||:|          :..|.||:      ..::||.:.||||:
Yeast   100 LIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQNYDKLIHEHPCGPLKKLFSDGTFYY-- 162

  Fly   134 TNASASASGASSYRFDIT-------LCAQRRQQTQETDNRFFWNRMMHIHLM--RFGIDCQSWLL 189
                       |..|||:       |...........|..|.||..:...::  |..|..:...|
Yeast   163 -----------SRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQL 216

  Fly   190 QAMCGSVE------VRTVYI--GAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVI 246
            .|..|.:.      .:|..|  |...|...||||:|.|.......:.|.:::|.|:.|||||.|:
Yeast   217 FANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETEIVV 281

  Fly   247 YVDGDVTSYVQTRGSVPLFWEQPGVQ-VGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNL 310
            ..:..:.||.|..||:|||||....| :...|:|:::....:..|||||...:..:||..::||:
Yeast   282 TTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNI 346

  Fly   311 LGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSALAK--------LKERI 367
            :..    ..|.:..|:..::   ..:..|.:.....:|       :.|.|.|        ||:.|
Yeast   347 IKP----KSESQEKLALTYK---DCAESKGIKITNIEY-------SSSVLTKSPHKLLYLLKQDI 397

  Fly   368 VACGANYGVFHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGI---QLEALKMGGKQQ 429
            ...||  ..:..|.|....:|.||:|.:..|.:::.|.|:..:..:.|.:   :::..::
Yeast   398 YEFGA--FAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEIDVFEL----- 455

  Fly   430 NISRFEEIFRQMWINNGNEVSKIYAGTGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLV 494
             .|.|.:...::|..|      .|           .:|      ||...:..::.|...:...|.
Yeast   456 -TSPFLDAHDKLWSEN------YY-----------WLD------RTYTKHTKNSGKYTKVYSKLF 496

  Fly   495 GSTLSSELADRARILLPSNMLHA-PTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVF 558
            ||        |.|:..|   ||. .:..|::|..:||   ..:...:..||:|::|.      :.
Yeast   497 GS--------RVRLYDP---LHIYISQYLKQLRSKYT---FEKDISIFAGTFNISGK------IP 541

  Fly   559 KDSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAE 623
            ||.:.||:.       .|::       ...|...|:|.||.||:|:|...:::|......:.|.:
Yeast   542 KDDIKDWIF-------PKSM-------SKEDEMADLYVIGLEEVVELTPGHMLATDPYVRQFWEK 592

  Fly   624 ELQKTIS---RDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIR 685
            ::...::   |...|:.|...||.|:.|.:::.......::.:..|..|||.||...||||.|:.
Yeast   593 KILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVS 657

  Fly   686 FVLHGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKD 750
            |....|..|.:.:|.|||...|.:|:.||..|.:.:.|..|..:|.||.:.|.|||||||.|..:
Yeast   658 FKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIKDHDAIIWMGDFNYRILMSNE 722

  Fly   751 ELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWT 815
            :::..:.:.:.:::.|.|||.::..||..|..|.|..|.|.||||:|..:.:||||||.|.||||
Yeast   723 DVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDPGTKNYDTSEKMRIPAWT 787

  Fly   816 DRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRA----V 876
            ||:| .|.:.|.:.::...            .::..||||||.||..|.:..:|:|::..    :
Yeast   788 DRIL-SRGEVLEQLEYKCC------------EDILFSDHRPVYAIFRARVTVVDEQKKTTLGTQI 839

  Fly   877 FEQVIRDLGPPDSTIVVHVLESSA------TGDED--GPT 908
            :|:::..|...|....:.||...|      .|.:.  |||
Yeast   840 YEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPT 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	82/335 (24%)
		INPP5c_Synj	538..863	CDD:197323	104/327 (32%)
		DUF1866	862..1008	CDD:286093	12/58 (21%)
INP51	NP_012264.3	COG5329	1..501	CDD:227637	120/531 (23%)
INP51	NP_012264.3	COG5411	498..946	CDD:227698	126/428 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I616
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm46901
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.870