Protein Alignment Synj and INP53

DIOPT Version :10

• Sequence 1: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_014752.3
• Gene: INP53 / 854276
• SGDID: S000005635
• Length: 1107
• Species: Saccharomyces cerevisiae
• Alignment Length: 1206
• Identity: 323/1206 - (26%)
• Similarity: 532/1206 - (44%)
• Gaps: 235/1206 - (19%)

  Fly    38 AVALLTQQETDVIRKQYTKVC--DAYGCLGALQLNAGESTVLFLVLVTG-------C--VSMGKI 91
            |:.||  |:.|:.:..:.::.  :.:|.:|.:::|.    :||:..:||       |  .::.||
Yeast    38 AIELL--QKNDLKKYGFKRLTSHEIFGVIGLIEVNG----LLFVGAITGKSKVAQPCPGETVNKI 96

  Fly    92 GDIEIFRIT------------------QTTFVSLQNAAPNEDKISEVRKLLNSGTFYFAHTNASA 138
            ..::.|.:.                  :|.....|:|.| :....|::|||::|:||:
Yeast    97 FAVDFFCLNDNSWDFIEIDSSGYPVLPETASTEYQDALP-KHPCYELKKLLSNGSFYY------- 153

  Fly   139 SASGASSYRFDITLCAQRR---QQTQETD---NRFFWNRMMHIHLMRFG----------IDCQSW 187
                  |..||:|...|.|   |.:..||   ..:.||..:...::.:.          :|.:.:
Yeast   154 ------SSDFDLTSTLQHRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGF 212

  Fly   188 LLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDV 252
            |...:.|..|....|:...:....|||:.|.:|||||||.||.:||..||||||||.::|.....
Yeast   213 LTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYC 277

  Fly   253 TSYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVG 317
            .::.|.|||:|:|||| |..:.:.:|:::|.||.:...||:|:....::||...|||||     .
Yeast   278 YAFTQIRGSIPVFWEQ-GTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLL-----S 336

  Fly   318 SKEGEAMLSNEFQRH--HG--MSAHKDVPHVVFDYHQECRGGNFSALAKLKERIV--ACGANYGV 376
            :|..|..||..::.|  |.  ::.:||:....||:|:|.....||.:.||...|:  ...:.|..
Yeast   337 TKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYS 401

  Fly   377 FHASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNI--SRFEEIFR 439
            :.....:.:.||.|:.||||||||||||..|..:.|......||..::......|  ..|.....
Yeast   402 YDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHN 466

  Fly   440 QMWINNGNEVSKIYAGTGAIQG----------GSKLMDGARSAARTIQNNLLDNSKQEAIDVLLV 494
            .:|.::|:::|:||.||.|::.          ...|.|..:|.:|...||.:|..||:.||.||
Yeast   467 TLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLL- 530

  Fly   495 GSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFK 559
                 ..|..:..:.|...:....:|.|:.:..::|.   .....:.:|::||||...      |
Yeast   531 -----GRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTS---TSNINLLIGSFNVNGATK------K 581

  Fly   560 DSLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEE 624
            ..|:.||.                |......| ||..:|.:|:::|:|.:|:.|....:..|...
Yeast   582 VDLSKWLF----------------PIGEKFKP-DIVVLGLQEVIELSAGSILNADYSKSSFWENL 629

  Fly   625 LQKTISR-DNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVL 688
            :...::: |:.|:||..:|:..:.:..:::.:.|.:::.|.....|||..|..|||||.:|||..
Yeast   630 VGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEY 694

  Fly   689 HGTSMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELK 753
            ..||.|||.:|.|||.:.|.||.:||..|.|.:.|...:.:..||.:||.||.||||::..::::
Yeast   695 GATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVR 759

  Fly   754 ECVRN---GDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWT 815
            ..:.|   |.:..:|.||||.....:|:||..|.|..:.|.||||||..:..||:|||:|.|:||
Yeast   760 RELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWT 824

  Fly   816 DRVLWRRRKALAEGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQV 880
            ||::::....|.              :.|..:.:..||||||.|...|:|..:|.:.|.::.:::
Yeast   825 DRIIYKGENLLP--------------LSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRL 875

  Fly   881 IRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDG 945
            ..:.             .....:|.|..|.|  ::|..:...|..|
Yeast   876 FTEY-------------KQEHPEEPGSLISD--LLSLDLDNKSTDG------------------- 906

  Fly   946 ESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQL-LQAITPEL 1009
               ..:||:.|:    ||             :|..:...|.::: ..::||..|.. ||.:..:.
Yeast   907 ---FKSSSESSL----LD-------------IDPIMAQPTASSV-ASSSPVSSASASLQPVRTQN 950

  Fly  1010 PQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPMP-PQPQSQPLI--------- 1064
            ..:.:.|..:|..|||.|.:         |..|.:..|..:|...| ||..:..|.
Yeast   951 SSQSRTPIKKPVLRPPPPPA---------HKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQEN 1006

  Fly  1065 -PSPLQPQVAPPRPPAMDTTPSSKS------QSPTELV-SASSSTSS---SGKTSPTA------- 1111
             |.....::.||.......||.|.|      .|..:|. |||.||.|   :.:.:|||
Yeast  1007 KPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDV 1071

  Fly  1112 ---PAVLSGPPTPPRQMQSKQATPVSTPTRQVGSPK 1144
               |..|.|...|....:..:...::..:.|..:||
Yeast  1072 NGQPEALLGDENPIEPEEKAKLNHMTLDSWQPLTPK 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_569729.1	COG5329	61..493	CDD:227637	144/492 (29%)
		INPP5c_Synj	538..863	CDD:197323	105/328 (32%)
		DUF1866	862..1008	CDD:286093	23/146 (16%)
INP53	NP_014752.3	COG5329	1..603	CDD:227637	169/622 (27%)
		INPP5c_ScInp51p-like	566..858	CDD:197324	105/328 (32%)