DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and FRA3

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_176736.2	Gene:	FRA3 / 842869	AraportID:	AT1G65580	Length:	1101	Species:	Arabidopsis thaliana

Alignment Length:	685	Identity:	171/685 - (24%)
Similarity:	261/685 - (38%)	Gaps:	191/685 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 GNFSALAKLKERIVA-------CGANYGVFHA--SNGQVLREQFGVVRTNCLDCLDRTNCVQTYL 410
            |.|...::..|.||.       .|::.|:...  .||..|:| |....:..| |: .|.|.:.::
plant   399 GGFCDDSRKTEAIVISVDGMIWTGSSNGILMRWDGNGNCLQE-FAYESSGIL-CM-FTFCSRLWV 460

  Fly   411 GLDTLGIQ---LEALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYAGT---------GAIQGGS 463
            |.....:|   ||...:||               |:.:...|.|:..|.         |.|:|.:
plant   461 GYSNGTVQVWDLEGKLLGG---------------WVAHSGPVIKMAIGAGYLFTLANHGGIRGWN 510

  Fly   464 KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKR 528
            ....|.           |||             .|.:|||.:..:
plant   511 VTSPGP-----------LDN-------------VLRAELAGKEFL-------------------- 531

  Fly   529 YTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALVDVNNPSENVDHPVD 593
               |.|....::..||:||..|:     ...|||..| |.|.|..                  |:
plant   532 ---YSRIENLKILAGTWNVGEGR-----ASTDSLVSW-LGCAATG------------------VE 569

  Fly   594 IYAIGFEEIVDLNASNI-MAASTDNAKL--------WAEELQKTISRDNDYVLLTYQQLVGVCLY 649
            |..:|.:| |::.|..: |:|:.:...|        |.:.:.||:...:.:|.:..:||.|:.:.
plant   570 IVVVGLQE-VEMGAGVLAMSAAKETVGLEGSPLGQWWLDMIGKTLDEGSSFVRVGSRQLAGLLIC 633

  Fly   650 IYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADY 714
            :::|.:..||:.||....|..|.|.|.|||||..:|..::...:|||..||||....|..||||:
plant   634 VWVRHDLKPHVGDVDAAAVPCGFGRAIGNKGAVGVRLRMYDRVLCFVNCHFAAHLEAVNRRNADF 698

  Fly   715 AEITRKLAF--------------------PMGRT------------LKSHDWVFWCGDFNYRI-D 746
            ..:.|.:.|                    |.|..            |...|.|.:.||||||: |
plant   699 DHVYRTMTFSRQSSSLNAGVAGASFGVTMPRGGNALGVNTIEARPELSEADMVIFLGDFNYRLDD 763

  Fly   747 MEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFS---DDYDTSEK 808
            :..||.::.:.......:.|.|||..|.||||||....|..|.|.||||::...   ..||:.||
plant   764 ITYDETRDFISQRCFDWLREKDQLHTEMEAGNVFQGMREAIIRFPPTYKFERHQAGLAGYDSGEK 828

  Fly   809 QRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHYGR-SELKQSDHRPVIAIIDAEIMEIDQQR 872
            :|.|||.||:|:|..|.....:.:........:..|.. .|:..|||:||..:...:|..:|:..
plant   829 KRIPAWCDRILYRDNKKHLGAECSLDCPVVSSISQYDACMEVTDSDHKPVRCVFSVKIARVDESV 893

  Fly   873 RRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDT 937
            ||                            .|.|..|.....:..|:.||||:.| |:|    .|
plant   894 RR----------------------------QEYGNIINSNKKIKVLLGELSKVPE-TIV----ST 925

  Fly   938 MWVTFRDGESA-LNASSKKSIQVCGLDLILELKSK 971
            ..:..::.:|. |..::|....:....:|.|.:||
plant   926 NNIILQNQDSTILRITNKSEKNIAFFKIICEGQSK 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532
		INPP5c_Synj	538..863	CDD:197323	109/370 (29%)
		DUF1866	862..1008	CDD:286093	23/111 (21%)
FRA3	NP_176736.2	WD40	182..510	CDD:421866	29/128 (23%)
		WD40 repeat	186..221	CDD:293791
		WD40 repeat	230..264	CDD:293791
		WD40 repeat	413..442	CDD:293791	6/29 (21%)
		WD40 repeat	449..481	CDD:293791	10/48 (21%)
		INPP5c	538..884	CDD:197308	109/370 (29%)
		Motile_Sperm	919..1043	CDD:421531	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810