DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Synj2

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001106842.1	Gene:	Synj2 / 84018	RGDID:	69436	Length:	1496	Species:	Rattus norvegicus

Alignment Length:	1406	Identity:	544/1406 - (38%)
Similarity:	746/1406 - (53%)	Gaps:	254/1406 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65
            ||:||.:|:|.:.....|.|||||.|.:.|.:|||:.|||.|..:|.:||:..|.|..|||||||
  Rat     1 MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLG 65

  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130
            .|.|.:|...:.||||||||.|:|:|.|.||::||.|.|..||..|..||::..::|:|:||.||
  Rat    66 ELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFY 130

  Fly   131 FAHTNASASASGASSYRFDITLCAQRR-QQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194
            ||..|..|.        ||:|:.||:: ....|....||||:::|:.|.:..::|..|||:.:||
  Rat   131 FAWPNDGAC--------FDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICG 187

  Fly   195 SVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTR 259
            .|.:||||...|||:|.:|||:||||||.||..||.||:|:|:|||||||.||:|..|:|:||.|
  Rat   188 VVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIR 252

  Fly   260 GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAM 324
            |||||||||||:|||||.::|.||.|.:|.||:|||.:::::||.|.|||||     ||:.||.:
  Rat   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLL-----GSRGGEEV 312

  Fly   325 LSNEFQRHHGMSAHK-DVPHVVFDYHQECRGGNFSALAK-LKERIVACGANYGVFHASNGQVLRE 387
            |:..|::....|.|. |.|.:.||:||..:|.....|.. |:.::.....::|||........|.
  Rat   313 LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRF 377

  Fly   388 QFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKI 452
            |.|.:|.||||||||||.||.::.|:.|.:|||:|.:..|... .||.|.|:.||..||:.:||:
  Rat   378 QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSKPIT-DRFVESFKAMWSLNGHGLSKV 441

  Fly   453 YAGTGAIQGGS---KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLP--- 511
            :.|:.|::|.:   ||.|||||.:||||:|..|..|||||.:||||...:.|..|:.|:||.
  Rat   442 FTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTA 506

  Fly   512 ------------SNMLHAPTT--VLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRS-IVFKDS 561
                        |.||....|  :|:.:.:|.:|:...:..::|:||:||||||.||| ::....
  Rat   507 LLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTE 571

  Fly   562 LADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQ 626
            |.|||||...|:   ..||    |::...|.||:|:||||:|:|:|.||:.|||.|.|:|.|:||
  Rat   572 LTDWLLDAPQLS---GAVD----SQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQ 629

  Fly   627 KTISRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGT 691
            |.|||.:.|:|||..|||||||||::||.|.|.|||||||.||||:||..|||||..|||..|.|
  Rat   630 KAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHST 694

  Fly   692 SMCFVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECV 756
            |.||:|:|..||||||.|||.||.|||.||:||.||.:.|||:||||||||||||:..:|:...|
  Rat   695 SFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFV 759

  Fly   757 RNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWR 821
            :..|...::|||||:.::.:|.:|.:|.||.|.|.||||||:.|..||||:|.|.|||||||||.
  Rat   760 KRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWW 824

  Fly   822 RRK----------ALAEGDFAASA-----WNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQ 871
            |:|          .|.:.|....|     |:||.|.:|||:||:.||||||:||::.|:.|:|..
  Rat   825 RKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVG 889

  Fly   872 RRRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGPTI-----YDENVMSALITELSKMGEVTLV 931
            .|..||::|....||.|:|::|::         ..||:     :.|::.:.|:..|...|.:.||
  Rat   890 ARERVFQEVSSVQGPLDATVIVNL---------QSPTLEERNEFPEDLRTELMQTLGNYGTIILV 945

  Fly   932 RYVEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDW-----QHLVDSEIELC----TTN 987
            |..:..|.|||.|..|||:......::|.|..:.:..|:|||     :.|:.....:.    |.|
  Rat   946 RINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTAN 1010

  Fly   988 TIPLCAN----------------------------PV---------EHAQLLQAITPELPQ---- 1011
            :..|..|                            ||         :.:..:.|.||....
  Rat  1011 SCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALA 1075

  Fly  1012 RPKQPPT----------------------RPPARPPMPMSPKNSPRHLPHVGVISIVPKPAKPPM 1054
            :.||.||                      |.|:|   .:|..|.||             |..||.
  Rat  1076 KKKQHPTYKDDADLMTLKLELEVAGNFRHRSPSR---SLSVPNRPR-------------PPHPPQ 1124

  Fly  1055 PPQP--------------------------QSQPLIP-SPLQPQVA------PPRPPAMDTTPSS 1086
            .|.|                          |:..|:| :|.||..|      |.....:.||.:.
  Rat  1125 RPPPPTGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQ 1189

  Fly  1087 KSQSPTELV---------SASSST--SSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPTRQV 1140
            ::::....:         ||..:|  .:.|.:.|.|..   |||..||:...:..|......|:.
  Rat  1190 EAEAAIRCLLEAGGGVPESAPGATPLRNQGSSKPEASL---GPPVLPRRPVPRVPTMKKPTLRRT 1251

  Fly  1141 GSPK--------------------------------DPIPSDTAYETASNIYEEIQEDVPAPRHP 1173
            |.|.                                .|:|....::....:     |..|:...|
  Rat  1252 GKPMLSEEQCEQQPVHFTMASQEMNLETPPPITAPIPPVPKPRTFQPGRGV-----ERRPSGGKP 1311

  Fly  1174 PPAGPPPVIGA-----PMGPPPPLPNRRGPPPIPNRSGNAP 1209
            .|...|||.||     |..|..|   ...|...|.|..:||
  Rat  1312 EPDDAPPVTGAVELSSPEAPEAP---SLAPKVPPRRKKSAP 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	148/293 (51%)
		INPP5c_Synj	538..863	CDD:197323	187/340 (55%)
		DUF1866	862..1008	CDD:286093	44/196 (22%)
Synj2	NP_001106842.1	Syja_N	61..342	CDD:280532	148/293 (51%)
		EEP	547..878	CDD:294334	185/337 (55%)
		DUF1866	889..1025	CDD:286093	37/144 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1083		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1149		12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1357		34/156 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1393..1413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339886
Domainoid	1	1.000	51	1.000	Domainoid score	I11293
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm45958
orthoMCL	1	0.900	-	-		OOG6_101787
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710