DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and 5PTASE13

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_172054.3	Gene:	5PTASE13 / 837069	AraportID:	AT1G05630	Length:	1170	Species:	Arabidopsis thaliana

Alignment Length:	1059	Identity:	229/1059 - (21%)
Similarity:	370/1059 - (34%)	Gaps:	371/1059 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DAY--GC-LGALQLNAGESTVLFLVLVTGCVSM--------------GKIGDIEIFRITQTTFVS 106
            |||  || :|.......|.|..|...||...:|              .|.|.|..:::.|:: ||
plant   179 DAYEAGCGIGGQVPRGDEDTAPFHESVTTSPTMCLVADQSNKLLWSGHKDGKIRAWKMDQSS-VS 242

  Fly   107 L--QNAAPNEDKISEVRKLLNSGTFYFAHTNASASASGASSYRFDITLCAQ------------RR 157
            .  .::.|.::::|           :.|| ....::...|||. |:..|::            .:
plant   243 HDDDDSDPFKERVS-----------WLAH-RGPVNSIVISSYG-DMWSCSEGGVIKIWPWDTLEK 294

  Fly   158 QQTQETDNRFFWNRMMHIHLMRFGIDCQSWL-LQAMC--GSVEVRTVYIGAKQARAAIISRLSCE 219
            ....:.:.:    .|..:.:.|..||.:|.: :...|  .|.||:.:...:.:|:...:..||
plant   295 SLLLKPEEK----HMAALLVERSAIDLRSQVTVNGTCSISSSEVKFLLADSVRAKVWAVQSLS-- 353

  Fly   220 RAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQPGVQV---------GS 275
                 |::       :.|...:..:|:.|||.    |:.||.:|...:|   ||         .:
plant   354 -----FSI-------WDARSKDLLKVLNVDGQ----VENRGDLPPIQDQ---QVDDEMKLKFFSA 399

  Fly   276 HKVKLSRGF-------------------ETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEG 321
            .|.:..:||                   ..||.||...     .|.....|:.:.|:...||..|
plant   400 SKREKPQGFLQRSRNAIMGAAGAVRRVATRSAGAFSED-----TRKTEAIVLAVDGTIWTGSISG 459

  Fly   322 EAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHASNGQVLR 386
            ..:     |.....:..:||.|    :|                |.|.|...:|
plant   460 LIV-----QWDGNGNRLRDVNH----HH----------------RPVLCFCTFG----------- 488

  Fly   387 EQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSK 451
                          ||     .|:|..:..||:  |.:.||          ....|:::...|.|
plant   489 --------------DR-----IYVGYASGYIQV--LDLDGK----------LISSWVSHNEPVIK 522

  Fly   452 IYAGTG-----AIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLP 511
            :.||.|     |..||.:       .........|||
plant   523 LAAGGGFIFSLATHGGVR-------GWYVTSPGPLDN---------------------------- 552

  Fly   512 SNMLHAPTTVLR-ELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARS 575
                     ::| ||.::.|.|.|....|:.:||:||..|:     ...|:|..||
plant   553 ---------IIRTELSQKETLYARQDNVRILIGTWNVGQGR-----ASHDALMSWL--------- 594

  Fly   576 KALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNI-MAASTDNAKL--------WAEELQKTISR 631
                      .:|...|.|.|:|.:| |::.|..: |:|:.:...|        |.:.:.|.:..
plant   595 ----------GSVTSDVGIVAVGLQE-VEMGAGFLAMSAAKETVGLEGSAVGQWWIDAIGKALDE 648

  Fly   632 DNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFV 696
            .|.:..:..:||.|:.:.::.|.:...|:.|:.:..|..|.|.|.||||...:|..::...||||
plant   649 KNTFERMGSRQLAGLLISLWARKDIRTHVGDLDVAAVPCGFGRAIGNKGGVGLRIRVYDRIMCFV 713

  Fly   697 CAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKS-----------------HDWVFWC------ 738
            ..|.||....|..||||:..|.|.:.|..|:.|.:                 ..::||.
plant   714 NCHLAAHLEAVNRRNADFNHIFRLMVFSRGQNLSNAAAGMVPYLFLSCSLGFSTYLFWLLYSSGL 778

  Fly   739 -------------------------------------------GDFNYRI-DMEKDELKECVRNG 759
                                                       ||||||: .:..||.::.:...
plant   779 PWALSLAAGVSTSAYTTKSNTIPSTGAEEIKSDLAAADMVAFFGDFNYRLFGITYDEARDFISQR 843

  Fly   760 DLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSD---DYDTSEKQRAPAWTDRVLWR 821
            ....:.|.||||.|.:.|.||....|..|||.||||::....   .||:.||:|.|||.|||::|
plant   844 SFDWLRERDQLRAEMKVGKVFQGMREALITFPPTYKFERNRSGLGGYDSGEKKRIPAWCDRVIYR 908

  Fly   822 RRKALAEGDFAASAWNPGKL---------IHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVF 877
                    |..:|.::...|         ::....::.:|||:||.....|.|..:|:..||...
plant   909 --------DTQSSPFSESNLQCPVVSSVIMYEACMDVTESDHKPVRCKFHATIAHVDKSVRRQEL 965

  Fly   878 EQVIR----------DLG-PPDSTIVVH--VLESSATGDEDGPTIYDENVMSALITELSKMGEVT 929
            .::||          ||. .|::::..:  ||:|.   |....||.:.:..|..|..:...|:..
plant   966 GKIIRSNEKILSIFEDLRFVPETSVSTNNIVLQSQ---DTVILTITNNSPTSQAIFNILCGGQAV 1027

  Fly   930 LVRYVEDTMWVTFRDGESA 948
                |:|       |||.|
plant  1028 ----VKD-------DGEDA 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	68/353 (19%)
		INPP5c_Synj	538..863	CDD:197323	103/412 (25%)
		DUF1866	862..1008	CDD:286093	25/100 (25%)
5PTASE13	NP_172054.3	WD40	<164..374	CDD:225201	45/230 (20%)
		WD40	207..>294	CDD:295369	16/100 (16%)
		WD40 repeat	446..474	CDD:293791	5/32 (16%)
		WD40 repeat	481..514	CDD:293791	12/74 (16%)
		RAB3GAP2_N	491..>523	CDD:291327	9/43 (21%)
		WD40 repeat	520..556	CDD:293791	11/79 (14%)
		INPP5c	571..951	CDD:197308	103/412 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810