DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Synj and Sacm1l

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001344414.1	Gene:	Sacm1l / 83493	MGIID:	1933169	Length:	609	Species:	Mus musculus

Alignment Length:	556	Identity:	162/556 - (29%)
Similarity:	256/556 - (46%)	Gaps:	87/556 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLGALQLNAGES 74
            |:..|.|....|........|.::.:..:..:....:.||.....|:  ..:|.||.:.|.||.
Mouse     9 LKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTR--PIFGILGTIHLVAGN- 70

  Fly    75 TVLFLVLVTGCVSMGKIGDIEIFRIT------------QTTFVSLQNAAPNEDKISEVRKLLNSG 127
               :||::|..:.:|:..:..::|.|            ..|.:.||:   |:..::.:..:|:..
Mouse    71 ---YLVVITKKMKVGECFNHAVWRATDFDVLSYKKTMLHLTDIQLQD---NKTFLAMLNHVLSMD 129

  Fly   128 TFYFAHTNASASASGASSYRFDITLCAQRRQQT----------QETDNRFFWNRMMHIHLMRFGI 182
            .|||:.|             :|:|...||...|          :..|.||.||.    ||:| .:
Mouse   130 GFYFSTT-------------YDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNG----HLLR-EL 176

  Fly   183 DCQ----SWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETE 243
            ..|    .:.|..:.|.:.:.:..|..|.....:|||.||.|||.|:.|||.:.||:.|||||||
Mouse   177 SAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETE 241

  Fly   244 QVIYVDGDVTSYVQTRGSVPLFWEQ-PGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTV 307
            |:::..|:..|:||||||:|:||.| |.::...|. ::|: .......|.||.......||.|.:
Mouse   242 QIVHYSGNRASFVQTRGSIPIFWSQRPNLKYKPHP-QISK-VANHMDGFQRHFDSQVIIYGKQVI 304

  Fly   308 VNLLGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGA 372
            :|     ||..|..|..|...|...........:.::.||:|:||:...:..|:.|.:::.....
Mouse   305 IN-----LVNHKGSEKPLEQTFANMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQD 364

  Fly   373 NYGVFHA-SNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLE---ALKMGGKQQNISR 433
            ....|.. |.|:|:..|.||.|:||:|||||||.:|:.|...:|..||:   .|.:|.|.:....
Mouse   365 ELSYFLVDSAGKVVTNQDGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDE 429

  Fly   434 FEEIFRQMWINNGNEVSKIYAGTGAI-----QGGSK-----LMDGARSAARTIQNNLLDNSKQEA 488
            ||:.::..|.:|.|..:|.||||||:     :.|.:     ||||..|..|..:||..|..:|::
Mouse   430 FEKTYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQLGLLMDGFNSLLRYYKNNFSDGFRQDS 494

  Fly   489 IDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRE 524
            || |.:|:....||..           |:|.:|.|:
Mouse   495 ID-LFLGNYSVDELES-----------HSPLSVPRD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	93/318 (29%)
		INPP5c_Synj	538..863	CDD:197323
		DUF1866	862..1008	CDD:286093
Sacm1l	NP_001344414.1	COG5329	57..513	CDD:227637	151/499 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920