DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Synj and 5PTase14

DIOPT Version :9

Sequence 1:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001189651.1	Gene:	5PTase14 / 817740	AraportID:	AT2G31830	Length:	1173	Species:	Arabidopsis thaliana

Alignment Length:	1028	Identity:	237/1028 - (23%)
Similarity:	388/1028 - (37%)	Gaps:	306/1028 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QETDVIRKQYTKVCDAY--GC-LGALQLNAGE------------STVLFLVLVTG--CVSMG-KI 91
            ||..|   ::..:.:||  || ||. |:..|:            |..|.|::..|  .|..| |.
plant   179 QENGV---RFWNLEEAYEVGCGLGG-QVRRGDEDTAPFHESVPTSPALCLLVDHGNRLVWTGHKD 239

  Fly    92 GDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFYFAHTNASASASGASSYRFDITLCAQR 156
            |.|..:::.|....:..::.|.::::|           :.|| ....:....|||. |:..|:..
plant   240 GKIRAWKMNQPNTTTADDSKPFKERLS-----------WQAH-RGPVNYIVISSYG-DMWSCSDG 291

  Fly   157 ---RQQTQETDNRFFWNRMMHIHLM-----RFGIDCQSWL-LQAMC--GSVEVRTVYIGAKQARA 210
               :..|.::..:....::...|:.     |.|||.:|.: :...|  .|.:|:.:.:...:|:.
plant   292 GVIKIWTLDSLEKSLVLKLEEKHMAALLVERSGIDLRSQVTVNGTCSISSSDVKFLLVDTVKAKV 356

  Fly   211 AIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWEQPGVQVGS 275
            ..:..||       |::       :.|...|..:|..:||.    |:.|..:|   ...|.||..
plant   357 WAVQHLS-------FSL-------WDAQNKELLKVFNIDGQ----VENRVDMP---PTQGQQVED 400

  Fly   276 HKVKL--------SRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRH 332
            .|.|.        |:||            :.|.|:.      ::|::  |:....|      .|.
plant   401 TKAKFFSAPKKEKSQGF------------LQRSRHA------IMGAA--GAVRRAA------TRS 439

  Fly   333 HGMSAHKDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHA--SNGQVLRE----QFGV 391
            .|..| :|...|             .|:|...:..:..|:..||...  .||..|||    |..|
plant   440 AGAFA-EDTRKV-------------EAIAIAADGSIWTGSMNGVIAQWDGNGSRLREVNHHQQAV 490

  Fly   392 VRTNCLDCL--DRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYA 454
            :   |. |.  ||     .|:|..:..||:  |.:|||          ....|:::...|.|:.|
plant   491 L---CF-CTFGDR-----IYVGYSSGYIQV--LDLGGK----------LIASWVSHNEPVIKLAA 534

  Fly   455 GTG-----AIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514
            |.|     |..||.:                              |..::|          |..:
plant   535 GGGFIFSLATHGGVR------------------------------GWYVTS----------PGPL 559

  Fly   515 LHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDSLADWLLDCHALARSKALV 579
               .:.:..||.::...|.|....::.:||:||..|:..|.     :|..||        ..|:.
plant   560 ---DSLIRTELSQKEMAYARQDSVKILIGTWNVGEGRASRG-----ALVSWL--------GSAVS 608

  Fly   580 DVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDN----------AKLWAEELQKTISRDND 634
            ||.           |.|||.:| ||:.| ..:|.||..          .:.|.:.:...:...|.
plant   609 DVG-----------IVAIGLQE-VDMGA-GFLAMSTAKETVGVEGSAVGQWWLDAIGNALDERNT 660

  Fly   635 YVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAH 699
            :..:..:||.|:.:.:::|.....|:.|:.:..|..|.|.|.||||...:|..::...||||..|
plant   661 FERMGSRQLAGLLISLWVRKSIRTHVGDLDVAAVPCGFGRAIGNKGGVGLRIRVYDRIMCFVNCH 725

  Fly   700 FAAGQSQVAERNADYAEITRKLAFPMGRTL----------------------------KSH---- 732
            .||....|..||||:..|.|.:.|..|:::                            |||
plant   726 LAAHLEAVTRRNADFNHIYRSMVFSKGQSVYTAAAAGASTSAQALKNNPNTNNSTEEEKSHLASA 790

  Fly   733 DWVFWCGDFNYRI-DMEKDELKECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKY 796
            |.|.:.||||||: .:..||.::.:.:.....:.|.||||:|...|.||....|..|||.||||:
plant   791 DLVAFFGDFNYRLFGITYDEARDFISHRSFDWLREKDQLRQEMNEGKVFQGMREALITFPPTYKF 855

  Fly   797 DLFS---DDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNPGKLIHY-GRSELKQSDHRPV 857
            :...   ..||:.||:|.|||.|||::|..::::..:.:.........|.| ...::.:|||:||
plant   856 EKNKPGLGGYDSGEKKRIPAWCDRVIYRDNQSISYTECSLKCPVVSSTIMYEACMDVTESDHKPV 920

  Fly   858 IAIIDAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALITEL 922
            ...:.|.|...|:..||                            .|.|..:.....:.|:..||
plant   921 RCKLHANIAHTDKSVRR----------------------------QELGKIVKSNEKLRAMFEEL 957

  Fly   923 SKMGEVT-----LVRYVEDTMWVTFRDGESALNASSKKSI--QVC-GLDLILE 967
            ..:.|.:     ::.:.:||...|.|:     .::|.::|  .|| |..|:.|
plant   958 KSVPETSVSTNNILLHSQDTFIFTIRN-----TSNSSRAIFNIVCKGQTLVRE 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	66/328 (20%)
		INPP5c_Synj	538..863	CDD:197323	105/371 (28%)
		DUF1866	862..1008	CDD:286093	22/114 (19%)
5PTase14	NP_001189651.1	WD40	218..551	CDD:295369	92/457 (20%)
		WD40	<218..384	CDD:225201	38/196 (19%)
		WD40 repeat	451..484	CDD:293791	10/32 (31%)
		WD40 repeat	490..523	CDD:293791	13/53 (25%)
		WD40 repeat	529..565	CDD:293791	11/78 (14%)
		INPP5c	580..926	CDD:197308	105/371 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810